Core D: Neuropathology Core

核心 D：神经病理学核心

• 批准号: 10472767
• 负责人: JULIE A. SCHNEIDER
• 金额: $ 38.47万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472767
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Atherosclerosis; Autopsy; Biological Markers; Blood; Blood Vessels; Brain; Catalogs; Cerebral Amyloid Angiopathy; Cerebrospinal Fluid; Cessation of life; Clinical; Collaborations; Collection; Communication; Communities; Consent; DNA; Data; Data Management Resources; Development; Diagnosis; Diagnostic; Disease; Drug or chemical Tissue Distribution; Education; Educational Materials; Faculty; Funding; Goals; Hemorrhage; Home; Image; Image Analysis; Individual; Institution; International; Intervention; Laboratories; Latino; Lewy Bodies; Lymphocyte; Mentors; Methods; Microscopic; Modernization; Participant; Pathologic; Pathology; Photography; Play; Prevention; Procedures; Process; Reproducibility; Research; Research Personnel; Resources; Role; Secure; Slide; Specimen; Translational Research; biomarker development; brain tissue; data management; data sharing; digital; education research; flexibility; indexing; innovation; neuroimaging; neuropathology; open data; outreach; preservation; recruit; religious order study; research study; sample collection; tool

ABSTRACT – NEUROPATHOLOGY CORE The Neuropathology Core will play a pivotal role to help achieve the overall Rush ADRC goals by supporting, promoting and facilitating innovative translational research. Specifically, the Neuropathology Core will promote collaborative, transparent, and reproducible research by providing investigators with expertise, mentoring, and a comprehensive and unique resource of biospecimens and data using contemporary laboratory methods, state-of-the-art diagnostics, and sophisticated statistical support and data management. The Neuropathology Core will do this in participation with the Administrative, Data Management and Statistical, Biomarker and Neuroimaging, and Outreach, Recruitment and Engagement Cores, and the Research Education Component working with ADRC core leaders and other colleagues and focusing on our well-characterized subjects in the Clinical Core, Religious Orders Study (ROS) and Latino Cores. Specifically, the Neuropathology Core will (1) Use rapid autopsy and optimal biospecimen collection procedures to obtain antemortem (blood, lymphocytes, DNA) and postmortem (brain, cerebrospinal fluid) biospecimens (2) Preserve, process and store antemortem (blood, lymphocytes, DNA) and postmortem (brain and CSF) biospecimens for clinical-pathologic and innovative translational research by using uniform best practice procedures for research studies while maintaining flexibility to accommodate special needs of specific researchers, studies, and collaborations. (3) Perform state-of-the-art assessments on brain tissue using contemporary macroscopic and microscopic procedures and collect state-of-the-art neuropathologic data and diagnoses, including data on AD, Lewy body, TDP, and HS, and vascular (gross and microinfarcts, hemorrhages, atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy) pathologies to support a wide range of studies. (4) Distribute antemortem and postmortem specimens and data, share expertise, and mentor junior researchers and faculty in neuropathology by making biospecimens, data, and expertise assessable to junior and established investigators within and across the ADRC community, and outside of the centers; also partaking in collaborative studies with other centers and projects funded by the National Institution Aging (e.g., NACC, ADGC) and other organizations seeking to advance research in AD/ADRD. (5) Catalogue all biospecimens, photography, neuropathologic data and diagnoses, digital slide images and tissue distribution, using modern and secure data management systems. These activities will support, promote and facilitate innovative translational research that will lead to effective prevention, diagnosis, and interventions for Alzheimer’s disease and Alzheimer’s Disease Related Disorders.

摘要-神经病理学核心 神经病理学核心将发挥关键作用，以帮助实现整体拉什ADRC目标的支持， 促进和促进创新的转化研究。具体来说，神经病理学核心将促进 通过为研究人员提供专业知识，指导， 一个全面和独特的生物标本和数据资源，使用当代实验室方法， 最先进的诊断技术、先进的统计支持和数据管理。神经病理学 核心将与行政、数据管理和统计、生物标志物和 神经影像学，外展，招聘和参与核心，以及研究教育部分 与ADRC核心领导人和其他同事合作，专注于我们在 临床核心，宗教秩序研究（ROS）和拉丁美洲核心。具体来说，神经病理学核心将（1） 使用快速尸检和最佳生物标本收集程序，以获得死前（血液，淋巴细胞， （2）保存、处理和储存死前标本 （血液、淋巴细胞、DNA）和尸检（脑和CSF）生物标本，用于临床病理学和 通过使用统一的最佳实践程序进行研究性学习， 保持灵活性，以适应特定研究人员，研究和合作的特殊需求。（三） 使用当代宏观和微观技术对脑组织进行最先进的评估 程序和收集最先进的神经病理学数据和诊断，包括AD，路易体， TDP和HS以及血管（大体和微梗塞、血管狭窄、动脉粥样硬化、小动脉硬化和 脑淀粉样血管病）病理学以支持广泛的研究。(4)在死前分发， 尸检标本和数据，分享专业知识，并指导初级研究人员和教师， 神经病理学，使生物标本，数据和专业知识评估，以初级和建立 调查员内部和整个ADRC社区，以及中心之外;也参与了 与国家老龄化研究所资助的其他中心和项目的合作研究（例如，NACC， ADGC）和其他寻求推进AD/ADRD研究的组织。(5)把所有的生物样本分类， 摄影，神经病理学数据和诊断，数字幻灯片图像和组织分布，使用现代 和安全的数据管理系统。这些活动将支持、促进和便利创新 转化研究，将导致有效的预防，诊断和干预阿尔茨海默病 和阿尔茨海默病相关疾病。