Rush Alzheimer's Disease Research Center

拉什阿尔茨海默病研究中心

• 批准号: 10669633
• 负责人: JULIE A. SCHNEIDER
• 金额: $ 310.65万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669633
• 关键词: Aging; Agreement; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Autopsy; Biological; Biological Markers; Biometry; Black Populations; Brain; Caregivers; Cell model; Clergy; Clinical; Cohort Studies; Communities; Data; Data Collection; Data Set; Dementia; Disease model; Education; Enrollment; Ethnic Origin; Evaluation; Exercise; Faculty; Funding; Goals; Grant; Heterogeneity; Human; Impaired cognition; Incentives; Infrastructure; Institution; Latino; Latino Population; Leadership; Magnetic Resonance Imaging; Methodology; Molecular Profiling; Nature; Organ Donations; Participant; Pathogenesis; Patients; Persons; Pilot Projects; Positron-Emission Tomography; Prevention; Procedures; Process; Publishing; Recommendation; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Science; Source; Specimen; Strategic Planning; Structure; Systems Biology; Trust; Work; cohort; collaborative environment; community based research; computer infrastructure; computerized tools; data harmonization; data management; data sharing; distributed data; education research; ethnic minority; follow-up; human data; innovation; multidisciplinary; neuroimaging; neuropathology; new therapeutic target; open data; outreach; patient engagement; predictive modeling; programs; public health priorities; public-private partnership; racial diversity; racial minority; recruit; relational database; religious order study; repository; statistics; student mentoring; virtual

ABSTRACT – OVERALL The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on the causes, treatments, and prevention of AD/ADRD. While the proposed Rush ADRC is for a new grant, it builds on three decades of work by the current Rush ADCC. The Rush ADRC has eight cores and one component, which align with the recommendations of the 2017 NIA strategic plan, including studies that: 1) recognize the heterogeneity and multifactorial nature of dementias; 2) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; 3) employ new research paradigms, e.g., systems biology, human cell modeling; 4) enable rapid and extensive sharing of data, disease models, specimens, and support open and team science; 5) develop computational tools and infrastructure for storage, integration, and analysis of large-scale biological and patient-relevant data; 6) build multidisciplinary translational teams in virtual and real spaces; 7) develop new pre-competitive public-private partnerships; 8) change academic, publishing, and funding incentives to promote collaborative, transparent, and reproducible research; and 9) engage patients, caregivers, and citizens as direct partners in research. The Administrative Core will provide scientific leadership to the Rush ADRC as a whole. The Religious Orders Study (ROS) Core will recruit and conduct annual evaluations of Catholic clergy without dementia who agree to organ donation. The Clinical and Latino Cores will collect data harmonized with on Blacks and Latinos without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach, Recruitment, and Engagement Core will provide a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical, ROS and Latino Cores, and other NIA funded initiatives. The Biomarker/Neuroimaging Core will process neuroimaging generated with other funds from all three Cores and affiliated studies, and document neuroimaging and biofluid biomarker data. The new Research and Education Component will provide structured mentoring of students and faculty at all levels. The Data Management and Statistical Core will provide the infrastructure that allows all other Cores and the REC to be maximally successful and impactful and will provide statistical support to users of ADRC resources especially junior investigators and trainees.

摘要-总体

项目成果

Registry-Managed Care Coordination and Education for Patients With Co-occurring Diabetes and Serious Mental Illness.

• DOI: 10.1176/appi.ps.202000096
• 发表时间: 2021-08-01
• 期刊: PSYCHIATRIC SERVICES
• 影响因子: 3.8
• 作者: Cook, Judith A.;Jonikas, Jessica A.;Steigman, Pamela J.;Glover, Crystal M.;Burke-Miller, Jane K.;Weidenaar, Joni;O'Neill, Sheila;Pavick, Debbie;Jami, Asma;Santos, Charles J.
• 通讯作者: Santos, Charles J.

Digital quantification of the MMSE interlocking pentagon areas: a three-stage algorithm.

MMSE 联锁五边形区域的数字量化：三阶段算法。

• DOI: 10.1038/s41598-024-59194-1
• 发表时间: 2024
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Kim,Namhee;Truty,Timothy;DukeHan,S;Heo,Moonseong;Buchman,AronS;Bennett,DavidA;Tasaki,Shinya
• 通讯作者: Tasaki,Shinya

Brain Insulin Signaling is Associated with Late-Life Cognitive Decline.

大脑胰岛素信号传导与晚年认知能力下降有关。

• DOI: 10.14336/ad.2023.1117
• 发表时间: 2023
• 期刊: Aging and disease
• 影响因子: 7.4
• 作者: Tong,Han;Capuano,AnaW;Carmichael,OwenT;Gwizdala,KathrynL;Bennett,DavidA;Ahima,RexfordS;Arnold,StevenE;Arvanitakis,Zoe
• 通讯作者: Arvanitakis,Zoe

A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease.

来自阿尔茨海默病患者和非阿尔茨海默病患者的单细胞转录组和多尺度网络的公共资源。

• DOI: 10.1101/2023.10.20.563319
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Wang,Qi;Antone,Jerry;Alsop,Eric;Reiman,Rebecca;Funk,Cory;Bendl,Jaroslav;Dudley,JoelT;Liang,WinnieS;Karr,TimothyL;Roussos,Panos;Bennett,DavidA;DeJager,PhilipL;Serrano,GeidyE;Beach,ThomasG;Keuren-Jensen,KendallVan;Mast
• 通讯作者: Mast

A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets.

• DOI: 10.1126/sciadv.abi8178
• 发表时间: 2021-11-12
• 期刊: Science advances
• 影响因子: 13.6
• 作者: Roberts JA;Varma VR;An Y;Varma S;Candia J;Fantoni G;Tiwari V;Anerillas C;Williamson A;Saito A;Loeffler T;Schilcher I;Moaddel R;Khadeer M;Lovett J;Tanaka T;Pletnikova O;Troncoso JC;Bennett DA;Albert MS;Yu K;Niu M;Haroutunian V;Zhang B;Peng J;Croteau DL;Resnick SM;Gorospe M;Bohr VA;Ferrucci L;Thambisetty M
• 通讯作者: Thambisetty M