Diet Patterns and Alzheimer Disease and Other Dementias

饮食模式与阿尔茨海默病和其他痴呆症

• 批准号: 10164689
• 负责人: JULIE A. SCHNEIDER
• 金额: $ 43.29万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10164689
• 关键词: Age; Aging; Alzheimer' s Disease; Alzheimer' s disease brain; American; Arteriosclerosis; Atherosclerosis; Autopsy; Berry; Biological; Blood Vessels; Body mass index; Brain; Brain imaging; Cerebral Amyloid Angiopathy; Clinical; Cohort Studies; DASH diet; Data; Dementia; Diabetes Mellitus; Diet; Dietary Intervention; Dietary Practices; Disease; Domestic Fowls; Epidemiology; Etiology; Fabaceae; Fishes; Food; Heart Diseases; Hybrids; Hypertension; Impaired cognition; Incidence; Individual; Infarction; Knowledge; Lewy Bodies; Link; Literature; Measures; Meat; Mediating; Mediterranean Diet; Memory; Memory Loss; Mind; Modification; Nerve Degeneration; Neurofibrillary Tangles; Neurons; Nutrient; Nuts; Participant; Pattern; Physical activity; Population; Prevalence; Prevention; Preventive therapy; Principal Investigator; Proteins; Public Health; Resources; Role; Science; Senile Plaques; Stroke; Structure; Vascular Dementia; Vegetables; age group; apolipoprotein E-4; brain health; cognitive function; cognitive reserve; conditioned fear; cost; dementia risk; density; dietary; effective therapy; experience; good diet; hippocampal sclerosis; hypercholesterolemia; imaging study; lifestyle intervention; neuropathology; presynaptic; programs; protein TDP-43; rapid growth; response; sex

Principal Investigator/Program Director (Last, First, Middle): Morris, Martha Clare This R01 application, entitled “Diet Patterns and Alzheimer's Disease and Other Dementia Neuropathologies” is a revised submission in response to PAR-15-356. By the year 2050 it is projected that there will be 13.5 million Americans with AD at a cost of $1.1 trillion. Currently there is no cure for AD and no effective treatments. Preventive therapies are thus crucial for heading off a public health crisis. It is estimated that delaying dementia onset by just 5 years will reduce the cost and prevalence of the disease by half. Lifestyle interventions are an excellent strategy for population- wide impact. There is considerable epidemiological evidence linking diet to AD prevention, supported by underlying biologic mechanisms in the disease etiology for individual nutrients. In addition, a large number of AD risk factors have a demonstrated dietary basis. Dietary patterns including the DASH and Mediterranean diets and a hybrid of these diets called MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay) have been related to slower rates of cognitive decline and decreased incidence of AD. To date there has not been a study that has related dietary patterns to Alzheimer disease brain neuropathology or other neuropathologies associated with dementia. The clinical-neuropathologic cohort study, the Rush Memory and Aging Project affords the unique opportunity to investigate the relation of these healthy diet patterns to brain neuropathologies and to brain health. The extensive clinical and dietary data obtained among 600 hundred study participants with autopsy data will allow for unprecedented examination of diet pattern relations to multiple neuropathologies associated with AD dementia (amyloid plaques, neurofibrillary tangles, and CERAD, Braak, and NIA Reagan scores), vascular dementia (macro- and micro-infarcts, TDP-43, atherosclerosis, arteriosclerosis, cerebral amyloid angiopathy), other dementias (Lewy bodies, hippocampal sclerosis) and presynaptic proteins, a measure of brain health and cognitive reserve. The study will also examine the potential mediating roles of brain neuropathologies and of presynaptic proteins on the MIND, DASH, and Mediterranean dietary pattern associations with decline in cognitive function and clinical dementia. The study will advance the science by identifying the neuropathologic biomechanisms underlying dietary relationships to cognitive decline, AD and other dementias. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

首席研究员/计划主任（最后，第一，中间）：莫里斯，玛莎·克莱尔 此R01应用名为“饮食模式和阿尔茨海默氏病和其他痴呆症 神经病理学”是对par-15-356的经修订的提交。到2050年，它是 预计将有1350万美国人的广告，成本为1.1万亿美元。目前有 无法治愈广告，也没有有效的治疗方法。因此，预防性疗法对于离开A至关重要 公共卫生危机。据估计，将痴呆发作延迟仅5年将降低成本 疾病的患病率增加了一半。生活方式干预是人口的绝佳策略 - 巨大的影响。有大量的流行病学证据将饮食与预防饮食联系起来，支持 通过在疾病病因学中的生物学机制的基本营养物质。此外，一个大的 AD风险因素的数量具有饮食基础。饮食模式在内 和地中海饮食和这些饮食的混合体称为Mind（地中海污染饮食 神经退行性延迟的干预）与认知能力下降的速度较慢和 AD事件减少。迄今为止，还没有一项与饮食模式相关的研究 阿尔茨海默氏病脑神经病理学或与痴呆相关的其他神经病理学。 临床 - 神经病理学队列研究，繁忙记忆和衰老项目提供了独特的 调查这些健康饮食模式与大脑神经病理学的关系和 大脑健康。在60000名研究参与者中获得的广泛临床和饮食数据 有了尸检数据，将允许对饮食模式关系进行前所未有的研究 与AD痴呆相关的神经病理学（淀粉样蛋白斑块，神经原纤维缠结和 Cerad，Braak和Nia Reagan得分），血管性痴呆（宏观和微生物，TDP-43， 动脉粥样硬化，动脉粥样硬化，脑淀粉样血管病），其他痴呆症（Lewy身体， 海马硬化症）和突触前蛋白，一种衡量脑健康和认知储备的度量。 该研究还将检查脑神经病理学和 在心灵，破折号和地中海饮食模式的脑海中的突触前蛋白与 认知功能和临床痴呆症的下降。这项研究将通过识别 饮食关系与认知能力下降，AD和AD和 其他痴呆症。 PHS 398/2590（修订版09/04，重新发行4/2006）页面延续格式页面