Rush Alzheimer's Disease Research Center

摘要-总体 拟议的拉什ADRC的总体目标是创造一个跨学科的环境，支持 关于AD/ADRD的病因、治疗和预防的创新研究。虽然拟议的拉什ADRC 是一个新的赠款，它建立在三十年的工作，目前拉什ADCC。拉什ADRC有八个 核心和一个组成部分，符合2017年NIA战略计划的建议，包括 研究：1）认识到痴呆的异质性和多因素性; 2）支持广泛的 分子分析，以填补大规模人类数据的空白，需要建立疾病的预测模型， 健康; 3）采用新的研究范式，例如，系统生物学，人类细胞建模; 4）使快速和 广泛共享数据、疾病模型、标本，支持开放和团队科学; 5）发展 计算工具和基础设施的存储，集成和分析大规模的生物和 患者相关数据; 6）在虚拟和真实的空间中建立多学科翻译团队; 7）开发新的 竞争前的公私伙伴关系; 8）改变学术，出版和资助激励措施，以促进 协作、透明和可重复的研究; 9）让患者、护理人员和公民参与进来， 研究中的直接合作伙伴。 行政核心将为整个拉什ADRC提供科学领导。的宗教命令 研究（ROS）核心将招募和进行年度评估的天主教神职人员没有痴呆症谁同意， 器官捐献临床和拉丁裔核心将收集与黑人和拉丁裔协调的数据， 痴呆症和进行大脑解剖的工作。神经病理学核心将处理、存储、评估并 分发临床、ROS和拉丁裔核心获得的生物标本。外展，招聘，和 Engagement Core将提供广泛的教育计划，以支持外展和招募 种族和少数民族纳入临床，ROS和拉丁美洲核心，以及其他NIA资助的倡议。的 生物标志物/神经成像核心将处理所有三个核心的其他资金产生的神经成像， 附属研究，并记录神经成像和生物流体生物标志物数据。新的研究和教育 组件将提供各级学生和教师的结构化指导。数据管理和 统计核心将提供基础设施，允许所有其他核心和REC最大限度地 成功和有影响力，并将为ADRC资源的用户，特别是初级用户提供统计支持 调查员和学员。

ABSTRACT – OVERALL The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on the causes, treatments, and prevention of AD/ADRD. While the proposed Rush ADRC is for a new grant, it builds on three decades of work by the current Rush ADCC. The Rush ADRC has eight cores and one component, which align with the recommendations of the 2017 NIA strategic plan, including studies that: 1) recognize the heterogeneity and multifactorial nature of dementias; 2) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; 3) employ new research paradigms, e.g., systems biology, human cell modeling; 4) enable rapid and extensive sharing of data, disease models, specimens, and support open and team science; 5) develop computational tools and infrastructure for storage, integration, and analysis of large-scale biological and patient-relevant data; 6) build multidisciplinary translational teams in virtual and real spaces; 7) develop new pre-competitive public-private partnerships; 8) change academic, publishing, and funding incentives to promote collaborative, transparent, and reproducible research; and 9) engage patients, caregivers, and citizens as direct partners in research. The Administrative Core will provide scientific leadership to the Rush ADRC as a whole. The Religious Orders Study (ROS) Core will recruit and conduct annual evaluations of Catholic clergy without dementia who agree to organ donation. The Clinical and Latino Cores will collect data harmonized with on Blacks and Latinos without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach, Recruitment, and Engagement Core will provide a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical, ROS and Latino Cores, and other NIA funded initiatives. The Biomarker/Neuroimaging Core will process neuroimaging generated with other funds from all three Cores and affiliated studies, and document neuroimaging and biofluid biomarker data. The new Research and Education Component will provide structured mentoring of students and faculty at all levels. The Data Management and Statistical Core will provide the infrastructure that allows all other Cores and the REC to be maximally successful and impactful and will provide statistical support to users of ADRC resources especially junior investigators and trainees.