Diet Patterns and Alzheimer Disease and Other Dementias

饮食模式与阿尔茨海默病和其他痴呆症

• 批准号: 9914165
• 负责人: JULIE A. SCHNEIDER
• 金额: $ 37.4万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9914165
• 关键词: Age; Aging; Alzheimer' s Disease; Alzheimer' s disease brain; American; Arteriosclerosis; Atherosclerosis; Autopsy; Berry; Biological; Blood Vessels; Brain; Brain imaging; Cerebral Amyloid Angiopathy; Clinical; Cohort Studies; DASH diet; Data; Dementia; Diabetes Mellitus; Diet; Dietary Intervention; Dietary Practices; Disease; Domestic Fowls; Epidemiology; Etiology; Fabaceae; Fishes; Food; Heart Diseases; Hybrids; Hypertension; Impaired cognition; Incidence; Individual; Infarction; Knowledge; Lewy Bodies; Link; Literature; Measures; Meat; Mediating; Mediterranean Diet; Memory; Memory Loss; Mind; Modification; Nerve Degeneration; Neurofibrillary Tangles; Neurons; Nutrient; Nuts; Participant; Pattern; Physical activity; Population; Prevalence; Prevention; Preventive therapy; Principal Investigator; Proteins; Public Health; Resources; Role; Science; Senile Plaques; Stroke; Structure; Vascular Dementia; Vegetables; age group; apolipoprotein E-4; brain health; cognitive function; cognitive reserve; conditioned fear; cost; dementia risk; density; effective therapy; experience; good diet; hippocampal sclerosis; hypercholesterolemia; imaging study; lifestyle intervention; neuropathology; presynaptic; programs; protein TDP-43; rapid growth; response; sex

Principal Investigator/Program Director (Last, First, Middle): Morris, Martha Clare This R01 application, entitled “Diet Patterns and Alzheimer's Disease and Other Dementia Neuropathologies” is a revised submission in response to PAR-15-356. By the year 2050 it is projected that there will be 13.5 million Americans with AD at a cost of $1.1 trillion. Currently there is no cure for AD and no effective treatments. Preventive therapies are thus crucial for heading off a public health crisis. It is estimated that delaying dementia onset by just 5 years will reduce the cost and prevalence of the disease by half. Lifestyle interventions are an excellent strategy for population- wide impact. There is considerable epidemiological evidence linking diet to AD prevention, supported by underlying biologic mechanisms in the disease etiology for individual nutrients. In addition, a large number of AD risk factors have a demonstrated dietary basis. Dietary patterns including the DASH and Mediterranean diets and a hybrid of these diets called MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay) have been related to slower rates of cognitive decline and decreased incidence of AD. To date there has not been a study that has related dietary patterns to Alzheimer disease brain neuropathology or other neuropathologies associated with dementia. The clinical-neuropathologic cohort study, the Rush Memory and Aging Project affords the unique opportunity to investigate the relation of these healthy diet patterns to brain neuropathologies and to brain health. The extensive clinical and dietary data obtained among 600 hundred study participants with autopsy data will allow for unprecedented examination of diet pattern relations to multiple neuropathologies associated with AD dementia (amyloid plaques, neurofibrillary tangles, and CERAD, Braak, and NIA Reagan scores), vascular dementia (macro- and micro-infarcts, TDP-43, atherosclerosis, arteriosclerosis, cerebral amyloid angiopathy), other dementias (Lewy bodies, hippocampal sclerosis) and presynaptic proteins, a measure of brain health and cognitive reserve. The study will also examine the potential mediating roles of brain neuropathologies and of presynaptic proteins on the MIND, DASH, and Mediterranean dietary pattern associations with decline in cognitive function and clinical dementia. The study will advance the science by identifying the neuropathologic biomechanisms underlying dietary relationships to cognitive decline, AD and other dementias. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

首席调查员/项目主任(最后、第一、中间)：莫里斯、玛莎·克莱尔 这个R01应用程序名为《饮食模式与阿尔茨海默病和其他痴呆症 《神经病理学》是对PAR-15-356的修改意见。到2050年，它将成为 预计将有1350万美国人患有AD，耗资1.1万亿美元。目前有 阿尔茨海默病无法治愈，也没有有效的治疗方法。因此，预防性治疗对于防止 公共卫生危机。据估计，将痴呆症的发病推迟5年将会降低成本。 并将疾病的流行率降低一半。生活方式干预对人群来说是一个很好的策略- 影响广泛。有相当多的流行病学证据将饮食与AD预防联系起来，支持 通过个体营养素在疾病病因学中的潜在生物机制。此外，还有一个大型的 许多AD危险因素都有明确的饮食基础。饮食模式，包括DASH 和地中海饮食以及这些饮食的混合体称为Mind(地中海破折号饮食 神经退行性延迟的干预)与认知衰退的速度较慢和 降低AD的发生率。到目前为止，还没有一项研究将饮食模式与 阿尔茨海默病、脑神经病理学或其他与痴呆症有关的神经病理学。这个 临床-神经病理队列研究，快速记忆和衰老项目提供了独特的 有机会研究这些健康饮食模式与脑神经病变的关系，并 大脑健康。在600,000名研究参与者中获得的广泛的临床和饮食数据 身体解剖数据将允许前所未有地检查饮食模式与多个 与AD痴呆相关的神经病理(淀粉样斑块、神经原纤维缠结和 CERAD，Braak和NIA Reagan评分)，血管性痴呆(大梗死灶和微梗死灶，TDP-43， 动脉粥样硬化、动脉硬化、脑淀粉样血管病)、其他痴呆(路易小体、 和突触前蛋白，这是一种衡量大脑健康和认知储备的指标。 这项研究还将考察脑神经病理和脑血管病变的潜在中介作用。 大脑上的突触前蛋白、DASH和地中海饮食模式与 认知功能下降和临床痴呆。这项研究将通过发现 饮食与认知功能减退、阿尔茨海默病和老年痴呆关系的神经病理生物机制 其他痴呆症。 PHS 398/2590(09/04版，2006年4月4日重新发布)页面续格式页面