North Carolina Diabetes Research Center

北卡罗来纳州糖尿病研究中心

• 批准号: 10382308
• 负责人: MICHAEL OLIVIER
• 金额: $ 18.4万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-07 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10382308
• 关键词: Bioinformatics; Biological; Cells; Clinical; Clinical Management; Complement; Complex; Computer Analysis; DNA; DNA Methylation; DNA sequencing; Data; Data Analyses; Development; Diabetes Mellitus; Disease; Disease Progression; Epigenetic Process; Faculty; Functional disorder; Gene Expression; Gene Expression Profile; Genes; Genetic Determinism; Genetic Predisposition to Disease; Genetic Transcription; Genome; Genomics; Goals; Health Sciences; Individual; Institution; Isotope Labeling; Knowledge; Lipids; Lipoproteins; Mass Spectrum Analysis; Metagenomics; Mitochondria; Molecular; Molecular Profiling; North Carolina; Pathway Analysis; Plasma; Play; Post-Translational Protein Processing; Preparation; Process; Proteins; Proteomics; RNA; RNA analysis; Research; Research Design; Research Personnel; Resources; Risk; Sampling; Serum; Services; Small RNA; Stable Isotope Labeling; System; Technology; Time; Tissues; Universities; Variant; Work; biological systems; cost efficient; diabetes risk; disorder risk; epigenetic regulation; epigenomics; exosome; experience; forest; individual patient; instrumentation; member; metabolomics; multiple omics; next generation sequencing; novel strategies; particle; precision medicine; programs; sample collection; small molecule; statistics; tool; transcriptome sequencing; whole genome

PROJECT SUMMARY/ABSTRACT – GENOMICS AND PROTEOMICS CORE As part of the North Carolina Diabetes Research Center (NCDRC), the Genomics and Proteomics Core (GPC) will utilize state-of-the-art resources and expertise in genomics and mass spectrometry at the Wake Forest Center for Precision Medicine to provide unique access to high-throughput instrumentation and analytical expertise to NCDRC faculty and affiliate members in support of ongoing and future research programs. The GPC builds on the extensive long-standing expertise and experience of several investigators who have supported Core components for other large-scale research efforts in genomics, epigenomics, proteomics and bioinformatics and statistics, and who are all part of the Center for Precision Medicine at Wake Forest University Health Sciences. The GPC will also coordinate the use of existing genomics, epigenomics, and proteomics resources at the partner institutions (UNC, NC A&T, and Duke University), and coordinate work and data analysis with the Metabolomics Core to provide the entire suite of omics analyses. The NCDRC GPC will offer analytic services, but equally importantly, the GPC will provide the knowledge and tools to integrate the data to better understand the interactive systems at play in disease processes.

项目概要/摘要-基因组学和蛋白质组学核心 作为北卡罗来纳州糖尿病研究中心（NCDRC）的一部分，基因组学和蛋白质组学核心（GPC） 将利用维克森林最先进的资源和基因组学和质谱学的专业知识 精准医学中心提供独特的高通量仪器和分析 专业知识，以NCDRC教师和附属成员支持正在进行和未来的研究计划。的GPC 建立在广泛的长期专业知识和经验的几个调查人员谁支持 基因组学、表观基因组学、蛋白质组学和生物信息学领域其他大规模研究工作的核心组成部分 他们都是维克森林大学健康中心精准医学的一部分 以理工科为重GPC还将协调现有基因组学、表观基因组学和蛋白质组学资源的使用 在合作机构（北卡罗来纳大学、北卡罗来纳州A&T大学和杜克大学），与 Metabolomics Core提供整套组学分析。NCDRC GPC将提供分析服务， 但同样重要的是，GPC将提供知识和工具来整合数据，以更好地了解 疾病过程中的互动系统。