The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health

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PROJECT SUMMARY Ohio includes a very diverse population, with many minority, underserved, and vulnerable communities (MUVP). The need to increase testing in Ohio’s MUVP is great – testing rates are only at 2.0 per 1000, with positivity rates indicating active community spread. With rapidly rising infection rates, ways to curb infection and morbidity/mortality are needed, especially in the most vulnerable populations. This RADx-UP Initiative Large Network proposal, RADx-UP Ohio, leverages the vast community partnership networks of the Ohio Center for Clinical and Translational Science Award and the OSU Comprehensive Cancer Center to identify reasons for and intervene to reduce disparities in COVID-19 education, testing, contact tracing, follow-up and treatment among MUVP in Ohio in a bi-directional academic-state-community partnership. This complements the work of Ohio Department of Health (ODH) emergency response to this pandemic. Our research process is guided by a socio-ecological model based on the Social Determinants of Health, the Proctor Model for Implementation Science2 and a Community-Based Participatory Research (CBPR) framework and prior preliminary work of the team, using an implementation science framework and overall program evaluation. The specific aims are to: Aim 1. Implement a multi-level intervention, built on effective interventions of the team, to increase the impact of COVID testing in MUVP in 12 selected counties informed by community partner input that will increase uptake of COVID-19 testing, knowledge of COVID-19 testing and results, and follow-up including contact tracing for positives. Aim 2. Assess the impact and sustainability of the intervention in different MUVP in Ohio. Aim 3. Interact with public health entities to disseminate successful strategies. The interventions will be culturally- appropriate and tailored to the needs of each MUVP in the 12 selected counties using an implementation science design, with counties randomized in a 3-wave step wedge design. RADx-Up Ohio includes the following Units: Community Engagement and Intervention; Testing; Statistics and Data Management); Human Subjects, and Evaluation. RADx-UP Ohio uses a hub and spoke model where the units provide expertise to support the activities of the 4 regional teams, each of which includes CHWs from each of the 3 individual counties with at least one community stakeholder to provide community context and ensure authentic partnerships are maintained. We will work closely with the RADx-UP Imitative components to successfully complete the aims.