The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health

项目总结 俄亥俄州人口非常多样化，有许多少数族裔、服务不足和弱势社区(MUVP)。 在俄亥俄州的MUVP增加检测的必要性是很大的-检测率只有2.0/1000，而阳性率 显示出活跃的社区传播。随着感染率的迅速上升，遏制感染和 需要发病率/死亡率，特别是在最脆弱的人群中。这个RADx-Up计划很大 网络建议，RADx-UP俄亥俄州，利用俄亥俄州中心庞大的社区合作网络 临床和转化科学奖和俄亥俄州立大学综合癌症中心确定原因 并采取干预措施，减少在新冠肺炎教育、检测、接触者追踪、随访和治疗方面的差距 在俄亥俄州的MUVP中，他建立了学术、州和社区的双向伙伴关系。这是对的工作的补充 俄亥俄州卫生部(ODH)对这场大流行做出了紧急反应。我们的研究过程是由一个 基于健康的社会决定因素的社会生态模型，普罗科特模型的实施 科学2和以社区为基础的参与性研究(CBPR)框架和以前的前期工作 团队，使用实施科学框架和总体计划评估。具体目标是：目标 1.在团队有效干预的基础上，实施多层次干预，以增加 在12个选定县的MUVP进行COVID检测，社区合作伙伴的投入将增加吸收率 新冠肺炎检测、新冠肺炎检测和结果的知识，以及包括接触者追踪在内的后续行动 积极的一面。目的2.评估干预对俄亥俄州不同MUVP的影响和可持续性。目标3. 与公共卫生实体互动，传播成功的战略。这些干预措施将在文化上- 利用实施科学，根据选定的12个县的每个MUVP的需求进行适当和量身定制 设计，在3波阶梯楔形设计中随机选择县。俄亥俄州RADx-UP包括以下单元： 社区参与和干预；测试；统计和数据管理)；人类受试者 评估。俄亥俄州的RADx-UP使用中心辐射型模式，其中各单位提供专业知识来支持 4个区域小组的活动，每个小组包括来自3个县的每个县的社区卫生工作者 至少有一个社区利益相关者提供社区背景并确保真正的合作伙伴关系 维护好了。我们将与RADx-UP模拟组件密切合作，成功完成目标。

PROJECT SUMMARY Ohio includes a very diverse population, with many minority, underserved, and vulnerable communities (MUVP). The need to increase testing in Ohio’s MUVP is great – testing rates are only at 2.0 per 1000, with positivity rates indicating active community spread. With rapidly rising infection rates, ways to curb infection and morbidity/mortality are needed, especially in the most vulnerable populations. This RADx-UP Initiative Large Network proposal, RADx-UP Ohio, leverages the vast community partnership networks of the Ohio Center for Clinical and Translational Science Award and the OSU Comprehensive Cancer Center to identify reasons for and intervene to reduce disparities in COVID-19 education, testing, contact tracing, follow-up and treatment among MUVP in Ohio in a bi-directional academic-state-community partnership. This complements the work of Ohio Department of Health (ODH) emergency response to this pandemic. Our research process is guided by a socio-ecological model based on the Social Determinants of Health, the Proctor Model for Implementation Science2 and a Community-Based Participatory Research (CBPR) framework and prior preliminary work of the team, using an implementation science framework and overall program evaluation. The specific aims are to: Aim 1. Implement a multi-level intervention, built on effective interventions of the team, to increase the impact of COVID testing in MUVP in 12 selected counties informed by community partner input that will increase uptake of COVID-19 testing, knowledge of COVID-19 testing and results, and follow-up including contact tracing for positives. Aim 2. Assess the impact and sustainability of the intervention in different MUVP in Ohio. Aim 3. Interact with public health entities to disseminate successful strategies. The interventions will be culturally- appropriate and tailored to the needs of each MUVP in the 12 selected counties using an implementation science design, with counties randomized in a 3-wave step wedge design. RADx-Up Ohio includes the following Units: Community Engagement and Intervention; Testing; Statistics and Data Management); Human Subjects, and Evaluation. RADx-UP Ohio uses a hub and spoke model where the units provide expertise to support the activities of the 4 regional teams, each of which includes CHWs from each of the 3 individual counties with at least one community stakeholder to provide community context and ensure authentic partnerships are maintained. We will work closely with the RADx-UP Imitative components to successfully complete the aims.