The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health

俄勒冈州立大学临床和转化科学中心：推进当今的发现以改善健康

• 批准号: 10474122
• 负责人: REBECCA D JACKSON
• 金额: $ 133.94万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-29 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474122
• 关键词: Address; Adopted; Adoption; Biomedical Research; Child Health; Childhood; Clinic; Clinical Sciences; Collaborations; Communities; Competence; Data; Data Analytics; Data Science; Development; Discipline; Education; Environment; Faculty; Foundations; Goals; Government; Grant; Health; Health system; Individual; Industry; Informatics; Information Dissemination; Institutes; Knowledge; Longevity; Methodology; Methods; Mission; Multi-Institutional Clinical Trial; Ohio; Participant; Pathway interactions; Patients; Pediatric Hospitals; Population; Process; Publications; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Resources; Role; Science; Scientist; Secure; System; Time; Training; Training Programs; Training Support; Training and Education; Translational Research; Translations; Universities; Vision; Work; Workforce Development; base; career; career development; clinical center; college; data sharing; data to knowledge; education resources; health inequalities; improved; innovation; member; novel strategies; programs; research study; skill acquisition; tool; translational approach; translational pipeline

PROJECT SUMMARY Ohio includes a very diverse population, with many minority, underserved, and vulnerable communities (MUVP). The need to increase testing in Ohio’s MUVP is great – testing rates are only at 2.0 per 1000, with positivity rates indicating active community spread. With rapidly rising infection rates, ways to curb infection and morbidity/mortality are needed, especially in the most vulnerable populations. This RADx-UP Initiative Large Network proposal, RADx-UP Ohio, leverages the vast community partnership networks of the Ohio Center for Clinical and Translational Science Award and the OSU Comprehensive Cancer Center to identify reasons for and intervene to reduce disparities in COVID-19 education, testing, contact tracing, follow-up and treatment among MUVP in Ohio in a bi-directional academic-state-community partnership. This complements the work of Ohio Department of Health (ODH) emergency response to this pandemic. Our research process is guided by a socio-ecological model based on the Social Determinants of Health, the Proctor Model for Implementation Science2 and a Community-Based Participatory Research (CBPR) framework and prior preliminary work of the team, using an implementation science framework and overall program evaluation. The specific aims are to: Aim 1. Implement a multi-level intervention, built on effective interventions of the team, to increase the impact of COVID testing in MUVP in 12 selected counties informed by community partner input that will increase uptake of COVID-19 testing, knowledge of COVID-19 testing and results, and follow-up including contact tracing for positives. Aim 2. Assess the impact and sustainability of the intervention in different MUVP in Ohio. Aim 3. Interact with public health entities to disseminate successful strategies. The interventions will be culturally- appropriate and tailored to the needs of each MUVP in the 12 selected counties using an implementation science design, with counties randomized in a 3-wave step wedge design. RADx-Up Ohio includes the following Units: Community Engagement and Intervention; Testing; Statistics and Data Management); Human Subjects, and Evaluation. RADx-UP Ohio uses a hub and spoke model where the units provide expertise to support the activities of the 4 regional teams, each of which includes CHWs from each of the 3 individual counties with at least one community stakeholder to provide community context and ensure authentic partnerships are maintained. We will work closely with the RADx-UP Imitative components to successfully complete the aims.

项目摘要 俄亥俄州包括一个非常多样化的人口，有许多少数民族，服务不足，弱势群体（MUVP）。 在俄亥俄州的MUVP中，增加检测的必要性很大-检测率仅为每1000人2.0，阳性率 这表明了活跃的社区传播。随着感染率的迅速上升，控制感染和 因此，需要对发病率/死亡率进行监测，特别是在最脆弱的人群中。此RADx-UP计划大型 网络提案，RADx-UP俄亥俄州，利用俄亥俄州中心的庞大社区合作伙伴网络， 临床和转化科学奖和俄勒冈州立大学综合癌症中心，以确定原因， 并进行干预，以减少COVID-19教育、检测、接触者追踪、随访和治疗方面的差异 在俄亥俄州的MUVP之间建立了一个双向的学术-州-社区伙伴关系。这补充了 俄亥俄州卫生部（ODH）对这一流行病的紧急反应。我们的研究过程是由一个 基于健康社会决定因素的社会生态模式，实施普罗克特模式 科学2和以社区为基础的前瞻性研究（CBPR）框架以及 团队，使用实施科学框架和整体计划评估。具体目标是： 1.在团队有效干预的基础上，实施多层次干预， 在12个选定的县进行MUVP的COVID测试，社区合作伙伴的投入将增加吸收 COVID-19检测，COVID-19检测和结果的知识，以及后续行动，包括接触者追踪， 积极的。目标2.评估干预措施在俄亥俄州不同MUVP中的影响和可持续性。目标3. 与公共卫生实体互动，传播成功的战略。干预措施将在文化上- 使用实施科学，根据12个选定县的每个MUVP的需求进行适当和定制 设计，县在3波阶梯楔形设计中随机化。RADx-Up俄亥俄州包括以下机组： 社区参与和干预;测试;统计和数据管理）;人类受试者，以及 评价RADx-UP俄亥俄州采用中心辐射模型，各单位提供专业知识， 4个区域小组的活动，每个小组包括来自3个州的社区卫生工作者， 至少有一个社区利益攸关方提供社区背景并确保真正的伙伴关系， 树立政治意识我们将与RADx-UP模拟组件密切合作，以成功完成目标。