Examining Neurophysiological Predictors of Treatment Response to a Multi-Component Early Intervention for Socially Inhibited Preschoolers

项目总结/摘要 父母的干预-控制型教养行为对儿童的稳定性有明显的影响作用， 儿童的行为抑制（BI）和作为焦虑症（AD）风险的调节剂， 针对这些行为的治疗和预防方法。容易被激起性欲的父母 并且难以对孩子的痛苦做出反应的人往往是无效的，苛刻的，侵入性的。 越来越多的研究表明，父母的生理影响他们的行为， 特别是在压力增大的时候。然而，很少有研究调查了 父母的神经生理反应和对IC行为的调节。尽管越来越多的人认为，... 有证据表明，神经生理功能可以预测干预后的行为变化，但没有证据表明， 搜索已经研究了这种可能性，关于IC养育或儿童BI。目前的建议包括- 使用现有的随机对照试验数据集（n = 151对父母-子女）（目的1）建立影响因素， 父母的神经生理调节对他们的IC养育行为的影响，以及这些联系是否是 目的2：探讨父母的神经生理调节和IC对儿童智力的影响 父母对治疗期间儿童BI降低的影响，儿童的神经生理调节是否介导 这些关联，以及父母焦虑的调节作用。海龟计划（TP），一个多组成部分 (i.e.,亲子互动疗法与儿童社会技能训练相结合）早期干预 计划，开发的目标IC父母，以减少风险的焦虑，学龄前儿童， 将其与BI的最佳心理教育治疗Cool Little Kids（R 01 MH 103253; PI： 目前的建议是专门研究父母的交感神经系统 (SNS)父母和儿童的副交感神经系统（PNS）功能在整个社会中进行评估。 压力源，考虑到PNS和SNS功能指数与唤醒有关的神经结构， 和注意力调节（RDoC唤醒和认知系统），并可能告知治疗反应。TP和 CLK，这两个都表明减少IC养育，系统地改变强度，结构， 所需资源。因此，目前的提案将为谁可能需要更多提供初步证据 强化治疗，这将促进个性化干预的发展，并减少患者的烧伤， 书房此外，该提案具有创新性和重要性，因为它将（1）建立流程， 父母和儿童的神经生理调节预测治疗反应的机制， (2)明确谁可能从更强化的治疗中受益，以及（3）提供对潜在治疗的初步见解。 治疗目标。

PROJECT SUMMARY/ABSTRACT The apparent and impactful role played by parents’ intrusive-controlling (IC) parenting behaviors in the stability of children’s behavioral inhibition (BI) and as a moderator of risk for anxiety disorders (AD) has motivated treatment and prevention approaches that specifically target these behaviors. Parents who are easily aroused and have difficulty regulating in response to their child’s distress are prone to ineffective, harsh, and intrusive parenting, and a growing body of research demonstrates that parents’ physiology influences their behaviors, particularly during times of heightened stress. However, very little research has investigated the influences of parents’ neurophysiological reactivity and regulation on IC behaviors. Moreover, although there is growing evi- dence that neurophysiological functioning may predict behavior change in response to intervention, no re- search has examined this possibility with regard to IC parenting or children’s BI. The current proposal leverag- es an existing randomized controlled trial dataset (n = 151 parent-child dyads) to (Aim 1) establish the influ- ences of parents’ neurophysiological regulation on their IC parenting behaviors and whether these links are moderated by parents’ anxiety and (Aim 2) test the influences of parents’ neurophysiological regulation and IC parenting on reductions in child BI across treatment, whether children’s neurophysiological regulation mediates these associations, and the moderating role of parents’ anxiety. The Turtle Program (TP), a multi-component (i.e., combination of Parent-Child Interaction Therapy and children’s Social Skills Training) early intervention program, was developed to target IC parenting to reduce risk for anxiety among preschool-aged children by comparing it to the best available psychoeducational treatment for BI, Cool Little Kids (R01MH103253; PIs: Rubin and Chronis-Tuscano).The current proposal specifically examines parents’ sympathetic nervous system (SNS) and parents’ and children’s parasympathetic nervous system (PNS) functioning assessed across social stressors, an impactful next step given PNS and SNS functioning index neural structures implicated in arousal and attention regulation (RDoC Arousal and Cognitive Systems) and may inform treatment response. TP and CLK, which have both demonstrated reductions in IC parenting, systematically vary in intensity, structure, and required resources. As such, the current proposal will provide preliminary evidence for who might need more intensive treatments which will promote the development of personalized intervention and reduce patient bur- den. Additionally, this proposal is innovative and significant because it will (1) establish the processes and mechanisms through which parents’ and children’s neurophysiological regulation predicts treatment response, (2) clarify who might benefit from more intensive treatments, and (3) provide preliminary insight into potential treatment targets.