CWRU Center for Excellence on the Impact of Substance Use on HIV

项目摘要-概述 新开发的CWRU(凯斯西储大学)卓越中心 药物使用对艾滋病毒的影响是在2017年8月构思的，并开始有效地 促进在基础、翻译和临床研究方面的卓越表现 物质使用和艾滋病毒。卓越中心包括12名由NIDA资助的调查人员 合计持有9个R01、2个DP1、3个R34、2个R44、1个U01和2个K01 克利夫兰大学医院克利夫兰医学中心，大都会健康医学中心 临床基金会、路易斯·斯托克斯克利夫兰退伍军人管理医疗中心、CWRU 曼德尔应用社会科学学院、Begin暴力预防研究中心和 教育部门，以及凯霍加县、洛雷恩县和克利夫兰市卫生局。 卓越中心的主要研究优势包括药物使用对艾滋病毒的影响 免疫发病机制、HIV潜伏期和治疗、神经艾滋病、胃肠功能障碍、性风险 行为，以及艾滋病毒和丙型肝炎病毒的共同感染。我们的研究以先进的计算技术为基础， 系统生物学、仿生模型和诱导多能干细胞(IPSC)技术 提供机会对阿片类药物、甲基苯丙胺、 大麻和可卡因的滥用对临床、病毒学、免疫学、行为学和 艾滋病毒疾病的神经学后果。英才中心有以下具体目标： ·提供科学领导，将该中心定位在物质使用的前沿 混乱研究及其作为国家药物使用研究资源的作用 在艾滋病毒携带者身上。 ·建立维持财政和管理监督的行政基础设施 所有的核心。 ·应用先进的计算生物学、原代细胞、仿生模型和IPSC- 研究物质使用对HIV疾病的影响。 ·通过获取独特的临床信息，支持翻译、临床和行为研究 药物使用障碍与艾滋病毒携带者和艾滋病毒风险人群的队列。 ·加快初级教师发展，鼓励有经验的教师进入 物质利用研究领域支持下一代调查人员。 ·参与社区外展。

Project Summary - Overview The newly developed CWRU (Case Western Reserve University) Center for Excellence on the Impact of Substance Use on HIV was conceived in August 2017 and was initiated to effectively promote excellence in basic, translational, and clinical research concerning the intersection between substance use and HIV. The Center for Excellence includes 12 NIDA-funded Investigators who collectively hold 9 R01, 2 DP1, 3 R34, 2 R44, 1 U01, and 2 K01 drawn from the CWRU School of Medicine, University Hospitals Cleveland Medical Center, MetroHealth Medical Center, the Cleveland Clinic Foundation, the Louis Stokes Cleveland Veterans Administration Medical Center, the CWRU Mandel School of Applied Social Sciences, the Begun Center for Violence Prevention Research and Education, and the Cuyahoga County, Lorain County, and City of Cleveland Departments of Health. Major research strengths in the Center for Excellence include impact of drug use on HIV immunopathogenesis, HIV latency and Cure, NeuroAIDS, gastrointestinal dysfunction, sexual risk behavior, and HIV and HCV co-infections. Our studies are anchored by advanced computational, systems biology, biomimetic models, and induced pluripotent stem cell (iPSC) technologies that provide the opportunity to perform meta-omics analyses of the impact of opioid, methamphetamine, cannabis, and cocaine misuse on several clinical, virological, immunological, behavioral, and neurological outcomes of HIV disease. The Center for Excellence has the following Specific Aims: • Provide scientific leadership to position the Center at the forefront of substance use disorder research and function as a national research resource for the study of drug use in persons with HIV. • Establish an administrative infrastructure that maintains fiscal and management oversight of the Cores. • Apply advanced Computational Biology, Primary Cells, Biomimetic models, and iPSC- derived Cells to study of the impact of substance use on HIV disease. • Support translational, clinical, and behavioral research through access to unique clinical cohorts of persons with substance use disorder with HIV and at risk for HIV. • Accelerate junior faculty development and encourage experienced faculty to enter the substance use research arena to support the next generation of investigators. • Participate in community outreach.