Training Program in HIV Cure

艾滋病毒治疗培训计划

• 批准号: 9203281
• 负责人: Alan David Levine
• 金额: $ 22.76万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9203281
• 关键词: HIV; Training Programs

The goal of this Training Program in HIV Cure (TPHC) is to provide outstanding training in basic, translational, and clinical research toward the HIV Cure agenda to outstanding predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 14 trainers and 8 junior trainers from 8 PhD programs, 11 departments in the School of Medicine, the Lerner College of Medicine, School of Dental Medicine, and the College of Arts and Sciences at Case Western Reserve University, and 9 clinical units at both University Hospitals (UH) Case Medical Center, the Louis Stokes Cleveland VA Medical Center, and the Cleveland Clinic Foundation, and is closely allied with the Case/UH Center for AIDS Research (CFAR). The participating 14 senior faculty is known for excellence in research, ample NIH and foundation funding, and robust research space, and have been specifically selected from a very large complement of excellent CFAR members to provide focus toward the single goal of curing an HIV infection in the periphery, the mucosa, and the brain. To expand the diversity of our trainers and to look to the future, we have also recruited 8 junior faculty, with strong developing programs who have not yet trained many investigators, yet will develop into outstanding preceptors through our co-mentoring program. Training focuses on relating the basic approaches of molecular and cellular virology, genomics, proteomics and systems biology, immunology, and clinical dissection of non-AIDS complications to mechanistic questions and solutions that address viral reservoirs, persistence, latency, immune exhaustion, systemic inflammation, and immune control, with particular emphasis on (a) Viral transcriptional regulation, (b) Host restriction factors, (c) Viral replication and reservoirs, (d) Systemic and mucosal immunity, (e) Clinical trials, (f) Signal transduction and gene expression, and (g) Systems biology and bioinformatics. Predoctoral training is accomplished through enrollment of students who have matriculated in the 8 PhD programs in Molecular Virology, Cell Biology, Immunology, Systems Biology and Bioinformatics, Chemistry, Doctorate of Nursing Practice, Molecular Medicine, and Epidemiology and Biostatistics. The basic coursework and guided training in research skills provided by these departmental programs in the three schools on the Health Sciences Campus, at the Lerner College of Medicine in the Cleveland Clinic Foundation, and in the College of Arts and Sciences, is supplemented and enhanced by TPHC-specific components. Postdoctoral trainees, who are appointed via their recruitment to a TPHC trainer’s lab as well as the CFAR, will also participate in the following programmatic and career development activities: (i) Completion of an additional, required graduate course in the Clinical Research Scholars Program (CRSP) at CWRU [http://casemed.case.edu/crsp] (ii) Participation in an exciting Clinical Immersion Experience in HIV clinical care at the University Hospitals Special Immunology Unit, the Louis Stokes Cleveland VA Medical Center, or the HIV Section of the Department of Infectious Diseases at the Cleveland Clinic Foundation (iii) Representation of the University on the Cleveland HIV Community Action Board (iv) International travel to Kampala, Uganda to interact with patients, scientists, and clinicians at the Joint Clinical Research Center [http://www.jcrc.org.ug], a Center of of Excellence that was started by H.E. President Yoweri Museveni in 1990 to address the very serious problem of HIV/AIDS in Africa (v) Establishing a CFAR-sponsored research working team with other TPHC trainees and the Fogarty trainees from Uganda on the CWRU campus (vi) Guest oral presentations at the CFAR internal and external annual retreats, in addition to the weekly seminar series and monthly journal club, organized by the CFAR, the Center for Global Health, the Division of Infectious Diseases, the Department of Molecular Biology and Microbiology, the Immunology Training Program, and the Molecular Medicine Program at the CCF (vii) Mentoring by a TPHC faculty committee that includes senior trainers and junior trainer faculty who are developing independent programs in cutting-edge areas of HIV Cure research This application seeks 4 positions (2 predocs and 2 mid-career PhD or MD postdocs per year).

该培训计划在艾滋病毒治疗（TPHC）的目标是提供基础，转化， 和临床研究对艾滋病毒治疗议程的优秀博士前学生和高素质的医学博士 或博士博士后研究员。该计划包括来自8个博士课程的14名培训师和8名初级培训师，11名 在医学院的部门，医学的勒纳学院，牙科医学院，和 凯斯西储大学文理学院，以及两所大学的9个临床单位 医院（UH）案例医疗中心，路易斯斯托克斯克利夫兰VA医疗中心和克利夫兰诊所 基金会，并与艾滋病研究中心（CFAR）密切结盟。参与者14 高级教师以卓越的研究，充足的NIH和基金会资金以及强大的研究而闻名 空间，并已专门从一个非常大的补充优秀CFAR成员， 为治疗外周、粘膜和大脑中的HIV感染这一单一目标提供关注。到 为了扩大我们培训师的多样性，并展望未来，我们还招募了8名初级教师， 开发计划，尚未培养出许多研究人员，但将发展成为优秀的导师 通过我们的共同指导计划。培训的重点是将分子和细胞的基本方法 病毒学、基因组学、蛋白质组学和系统生物学、免疫学和非艾滋病的临床解剖 复杂的机械问题和解决方案，解决病毒库，持久性，潜伏期， 免疫衰竭、全身性炎症和免疫控制，特别强调（a）病毒 转录调控，（B）宿主限制因子，（c）病毒复制和储库，（d）系统和 粘膜免疫，（e）临床试验，（f）信号转导和基因表达，以及（g）系统生物学和 生物信息学博士前培训是通过招收学生谁已经录取， 分子病毒学，细胞生物学，免疫学，系统生物学和生物信息学的8个博士课程， 化学，护理实践，分子医学，流行病学和生物统计学博士学位。基本 课程和指导培训的研究技能提供这些部门的计划在三个 克利夫兰临床基金会勒纳医学院健康科学校区的学校， 在艺术和科学学院，补充和加强了TPHC的具体组成部分。 博士后学员，谁是通过他们的招聘TPHC培训师的实验室以及CFAR任命，将 还参加下列方案和职业发展活动： (i)完成临床研究学者计划的额外必修研究生课程 （CRSP）在CWRU [http：//casemed.case.edu/crsp] (ii)在大学参与一个令人兴奋的临床沉浸在艾滋病毒临床护理的经验 医院特殊免疫科，路易斯斯托克斯克利夫兰退伍军人医疗中心，或艾滋病毒 克利夫兰诊所基金会传染病科 (iii)代表大学参加克利夫兰艾滋病毒社区行动委员会 (iv)前往乌干达坎帕拉与患者、科学家和临床医生进行互动， 联合临床研究中心[http://www.jcrc.org.ug]，一个卓越的中心， 阁下1990年，约韦里·穆塞韦尼总统提出了解决艾滋病毒/艾滋病这一非常严重的问题的建议， 非洲 (v)与其他TPHC学员和Fogarty一起建立CFAR赞助的研究工作团队 来自乌干达的学员在CWRU校园 (vi)在CFAR内部和外部年度务虚会上，除了 每周研讨会系列和每月杂志俱乐部，由CFAR组织，全球中心 卫生部，传染病科，分子生物学和微生物学系， 免疫学培训计划和CCF的分子医学计划 (vii)由TPHC教师委员会指导，包括高级培训师和初级培训师， 正在开发艾滋病毒治疗研究前沿领域的独立项目 此应用程序寻求4个职位（每年2个predocs和2个职业中期博士或MD博士后）。