Training Program in HIV Cure

艾滋病毒治疗培训计划

• 批准号: 9203281
• 负责人: Alan David Levine
• 金额: $ 22.76万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9203281
• 关键词: HIV; Training Programs

The goal of this Training Program in HIV Cure (TPHC) is to provide outstanding training in basic, translational, and clinical research toward the HIV Cure agenda to outstanding predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 14 trainers and 8 junior trainers from 8 PhD programs, 11 departments in the School of Medicine, the Lerner College of Medicine, School of Dental Medicine, and the College of Arts and Sciences at Case Western Reserve University, and 9 clinical units at both University Hospitals (UH) Case Medical Center, the Louis Stokes Cleveland VA Medical Center, and the Cleveland Clinic Foundation, and is closely allied with the Case/UH Center for AIDS Research (CFAR). The participating 14 senior faculty is known for excellence in research, ample NIH and foundation funding, and robust research space, and have been specifically selected from a very large complement of excellent CFAR members to provide focus toward the single goal of curing an HIV infection in the periphery, the mucosa, and the brain. To expand the diversity of our trainers and to look to the future, we have also recruited 8 junior faculty, with strong developing programs who have not yet trained many investigators, yet will develop into outstanding preceptors through our co-mentoring program. Training focuses on relating the basic approaches of molecular and cellular virology, genomics, proteomics and systems biology, immunology, and clinical dissection of non-AIDS complications to mechanistic questions and solutions that address viral reservoirs, persistence, latency, immune exhaustion, systemic inflammation, and immune control, with particular emphasis on (a) Viral transcriptional regulation, (b) Host restriction factors, (c) Viral replication and reservoirs, (d) Systemic and mucosal immunity, (e) Clinical trials, (f) Signal transduction and gene expression, and (g) Systems biology and bioinformatics. Predoctoral training is accomplished through enrollment of students who have matriculated in the 8 PhD programs in Molecular Virology, Cell Biology, Immunology, Systems Biology and Bioinformatics, Chemistry, Doctorate of Nursing Practice, Molecular Medicine, and Epidemiology and Biostatistics. The basic coursework and guided training in research skills provided by these departmental programs in the three schools on the Health Sciences Campus, at the Lerner College of Medicine in the Cleveland Clinic Foundation, and in the College of Arts and Sciences, is supplemented and enhanced by TPHC-specific components. Postdoctoral trainees, who are appointed via their recruitment to a TPHC trainer’s lab as well as the CFAR, will also participate in the following programmatic and career development activities: (i) Completion of an additional, required graduate course in the Clinical Research Scholars Program (CRSP) at CWRU [http://casemed.case.edu/crsp] (ii) Participation in an exciting Clinical Immersion Experience in HIV clinical care at the University Hospitals Special Immunology Unit, the Louis Stokes Cleveland VA Medical Center, or the HIV Section of the Department of Infectious Diseases at the Cleveland Clinic Foundation (iii) Representation of the University on the Cleveland HIV Community Action Board (iv) International travel to Kampala, Uganda to interact with patients, scientists, and clinicians at the Joint Clinical Research Center [http://www.jcrc.org.ug], a Center of of Excellence that was started by H.E. President Yoweri Museveni in 1990 to address the very serious problem of HIV/AIDS in Africa (v) Establishing a CFAR-sponsored research working team with other TPHC trainees and the Fogarty trainees from Uganda on the CWRU campus (vi) Guest oral presentations at the CFAR internal and external annual retreats, in addition to the weekly seminar series and monthly journal club, organized by the CFAR, the Center for Global Health, the Division of Infectious Diseases, the Department of Molecular Biology and Microbiology, the Immunology Training Program, and the Molecular Medicine Program at the CCF (vii) Mentoring by a TPHC faculty committee that includes senior trainers and junior trainer faculty who are developing independent programs in cutting-edge areas of HIV Cure research This application seeks 4 positions (2 predocs and 2 mid-career PhD or MD postdocs per year).

该艾滋病毒治疗培训计划 (TPHC) 的目标是提供基础、转化、 以及针对艾滋病毒治疗议程的临床研究，为优秀的博士生和高素质的医学博士提供帮助 或博士后研究员。该计划包括来自 8 个博士项目、11 个项目的 14 名培训师和 8 名初级培训师 医学院、勒纳医学院、牙科医学院和 凯斯西储大学艺术与科学学院以及两所大学的 9 个临床单位 医院 (UH) 凯斯医疗中心、路易斯斯托克斯克利夫兰退伍军人医疗中心和克利夫兰诊所 基金会，并与凯斯/呃艾滋病研究中心 (CFAR) 密切合作。参赛14 高级教师以卓越的研究、充足的 NIH 和基金会资金以及稳健的研究而闻名 空间，并且是从大量优秀的 CFAR 成员中专门挑选出来的 重点关注治愈外周、粘膜和大脑的艾滋病毒感染的单一目标。到 扩大培训师的多元化，着眼于未来，我们还招聘了8名初级教师，具有较强的实力。 开发项目，尚未培训出许多研究者，但将发展成为优秀的导师 通过我们的共同指导计划。培训重点是将分子和细胞的基本方法联系起来 病毒学、基因组学、蛋白质组学和系统生物学、免疫学以及非艾滋病的临床剖析 机械问题的复杂性和解决病毒库、持久性、潜伏期的解决方案， 免疫耗竭、全身炎症和免疫控制，特别强调 (a) 病毒 转录调控，(b) 宿主限制因子，(c) 病毒复制和储存库，(d) 系统性和 粘膜免疫，(e) 临床试验，(f) 信号转导和基因表达，以及 (g) 系统生物学和 生物信息学。博士前培训是通过招收已入读大学的学生来完成的 分子病毒学、细胞生物学、免疫学、系统生物学和生物信息学的 8 个博士课程， 化学、护理实践、分子医学、流行病学和生物统计学博士学位。基本的 这些部门计划在三个领域提供研究技能的课程作业和指导培训 健康科学校区的学校、克利夫兰诊所基金会的勒纳医学院、 在艺术与科学学院，TPHC 特定成分得到补充和增强。 通过招聘被任命为 TPHC 培训师实验室和 CFAR 的博士后实习生将 还参加以下计划和职业发展活动： (i) 完成临床研究学者计划中额外的必修研究生课程 (CRSP) CWRU [http://casemed.case.edu/crsp] (ii) 参与大学令人兴奋的艾滋病毒临床护理临床浸入式体验 医院特殊免疫科、路易斯斯托克斯克利夫兰退伍军人医疗中心或艾滋病毒 克利夫兰诊所基金会传染病科 (iii) 大学在克利夫兰艾滋病毒社区行动委员会的代表 (iv) 前往乌干达坎帕拉的国际旅行，与患者、科学家和临床医生互动 联合临床研究中心 [http://www.jcrc.org.ug]，卓越中心成立 由 H.E. 1990 年，约韦里·穆塞韦尼 (Yoweri Museveni) 总统解决了非常严重的艾滋病毒/艾滋病问题。 非洲 (v) 与其他 TPHC 学员和 Fogarty 建立 CFAR 资助的研究工作团队 来自乌干达的学员在 CWRU 校园 (vi) 除 CFAR 内部和外部年度静修会上的嘉宾口头报告外 由 CFAR（全球研究中心）组织的每周研讨会系列和每月期刊俱乐部 卫生、传染病科、分子生物学和微生物学系， CCF 的免疫学培训项目和分子医学项目 (vii) 由 TPHC 教师委员会提供指导，该委员会包括高级培训师和初级培训师教师， 正在艾滋病毒治疗研究的前沿领域开发独立项目 该申请寻求 4 个职位（每年 2 个博士前和 2 个职业生涯中期的博士或医学博士后）。