Training Program in HIV Cure

艾滋病毒治疗培训计划

• 批准号: 9203281
• 负责人: Alan David Levine
• 金额: $ 22.76万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9203281
• 关键词: HIV; Training Programs

The goal of this Training Program in HIV Cure (TPHC) is to provide outstanding training in basic, translational, and clinical research toward the HIV Cure agenda to outstanding predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 14 trainers and 8 junior trainers from 8 PhD programs, 11 departments in the School of Medicine, the Lerner College of Medicine, School of Dental Medicine, and the College of Arts and Sciences at Case Western Reserve University, and 9 clinical units at both University Hospitals (UH) Case Medical Center, the Louis Stokes Cleveland VA Medical Center, and the Cleveland Clinic Foundation, and is closely allied with the Case/UH Center for AIDS Research (CFAR). The participating 14 senior faculty is known for excellence in research, ample NIH and foundation funding, and robust research space, and have been specifically selected from a very large complement of excellent CFAR members to provide focus toward the single goal of curing an HIV infection in the periphery, the mucosa, and the brain. To expand the diversity of our trainers and to look to the future, we have also recruited 8 junior faculty, with strong developing programs who have not yet trained many investigators, yet will develop into outstanding preceptors through our co-mentoring program. Training focuses on relating the basic approaches of molecular and cellular virology, genomics, proteomics and systems biology, immunology, and clinical dissection of non-AIDS complications to mechanistic questions and solutions that address viral reservoirs, persistence, latency, immune exhaustion, systemic inflammation, and immune control, with particular emphasis on (a) Viral transcriptional regulation, (b) Host restriction factors, (c) Viral replication and reservoirs, (d) Systemic and mucosal immunity, (e) Clinical trials, (f) Signal transduction and gene expression, and (g) Systems biology and bioinformatics. Predoctoral training is accomplished through enrollment of students who have matriculated in the 8 PhD programs in Molecular Virology, Cell Biology, Immunology, Systems Biology and Bioinformatics, Chemistry, Doctorate of Nursing Practice, Molecular Medicine, and Epidemiology and Biostatistics. The basic coursework and guided training in research skills provided by these departmental programs in the three schools on the Health Sciences Campus, at the Lerner College of Medicine in the Cleveland Clinic Foundation, and in the College of Arts and Sciences, is supplemented and enhanced by TPHC-specific components. Postdoctoral trainees, who are appointed via their recruitment to a TPHC trainer’s lab as well as the CFAR, will also participate in the following programmatic and career development activities: (i) Completion of an additional, required graduate course in the Clinical Research Scholars Program (CRSP) at CWRU [http://casemed.case.edu/crsp] (ii) Participation in an exciting Clinical Immersion Experience in HIV clinical care at the University Hospitals Special Immunology Unit, the Louis Stokes Cleveland VA Medical Center, or the HIV Section of the Department of Infectious Diseases at the Cleveland Clinic Foundation (iii) Representation of the University on the Cleveland HIV Community Action Board (iv) International travel to Kampala, Uganda to interact with patients, scientists, and clinicians at the Joint Clinical Research Center [http://www.jcrc.org.ug], a Center of of Excellence that was started by H.E. President Yoweri Museveni in 1990 to address the very serious problem of HIV/AIDS in Africa (v) Establishing a CFAR-sponsored research working team with other TPHC trainees and the Fogarty trainees from Uganda on the CWRU campus (vi) Guest oral presentations at the CFAR internal and external annual retreats, in addition to the weekly seminar series and monthly journal club, organized by the CFAR, the Center for Global Health, the Division of Infectious Diseases, the Department of Molecular Biology and Microbiology, the Immunology Training Program, and the Molecular Medicine Program at the CCF (vii) Mentoring by a TPHC faculty committee that includes senior trainers and junior trainer faculty who are developing independent programs in cutting-edge areas of HIV Cure research This application seeks 4 positions (2 predocs and 2 mid-career PhD or MD postdocs per year).

该艾滋病毒治疗（TPHC）的该培训计划的目标是提供基本，翻译， 以及针对艾滋病毒治疗议程的临床研究，向杰出的前学生和高素质的医学博士 或博士博士后研究员。该计划包括来自8个博士学位课程的14名培训师和8位初级培训师，11个 医学院，勒纳医学院，牙科医学院和 Case Western Reserve University的艺术与科学学院，两所大学的9个临床单位 医院（UH）病例医疗中心，路易斯·斯托克斯克利夫兰弗吉尼亚州医疗中心和克利夫兰诊所 基金会，并与案例/UH艾滋病研究中心（CFAR）密切相关。参与14 高级教职员工以卓越的研究，足够的NIH和基金会资金而闻名以及强大的研究 空间，并已被专门从很大的优秀CFAR成员完成到 将注意力集中在治疗周围，粘膜和大脑中的HIV感染的单一目标。到 扩大我们教练的多样性并展望未来，我们还招募了8名初级教师， 开发尚未培训许多调查人员的计划，但会发展成为出色的受体 通过我们的同学计划。培训的重点是关联分子和细胞的基本方法 病毒学，基因组学，蛋白质组学和系统生物学，免疫学和非AID的临床解剖 机械问题和解决方案的并发症 免疫疲惫，全身性炎症和免疫控制，特别强调（a）病毒 转录调节，（b）宿主限制因素，（c）病毒复制和储层，（d）全身和 粘膜免疫，（e）临床试验，（f）信号翻译和基因表达，以及（g）系统生物学和 生物信息学。通过入学的学生来完成培训前培训 分子病毒学，细胞生物学，免疫学，系统生物学和生物信息学中的8个博士学位课程， 化学，护理实践博士学位，分子医学以及流行病学和生物统计学。基本 这些部门计划提供的课程和指导培训在三个部门提供的研究技能 在克利夫兰诊所基金会勒纳医学院的健康科学校园的学校， 在艺术和科学学院，TPHC特异性组成部分补充了和增强。 博士后学员是通过招募到TPHC培训师实验室以及CFAR的任命 还参与以下计划和职业发展活动： （i）完成临床研究学者计划的额外的，必需的研究生课程 （CRSP）在CWRU [http://casemed.case.edu/crsp] （ii）参加大学的HIV临床护理中令人兴奋的临床沉浸体验 医院特殊免疫学部门，路易斯·斯托克斯克利夫兰弗吉尼亚州医疗中心或艾滋病毒 克利夫兰诊所基金会传染病系 （iii）大学代表克利夫兰艾滋病毒社区行动委员会 （iv）国际前往乌干达的坎帕拉，与患者，科学家和临床医生互动 联合临床研究中心[http://www.jcrc.org.ug]，卓越的中心 由H.E. 1990年总统Yoweri Museveni总统解决了非常严重的艾滋病毒/艾滋病问题 非洲 （v）与其他TPHC受训者和Fogarty建立CFAR赞助的研究工作团队 来自CWRU校园的乌干达的学员 （vi）CFAR内部和外部年度务虚会的客人口头演讲，此外 由全球中心CFAR组织的每周节目系列和每月期刊俱乐部 健康，传染病司，分子生物学和微生物学系， 免疫学培训计划和CCF的分子医学计划 （vii）由TPHC教师委员会的指导，包括高级培训师和初级培训师教师 正在开发艾滋病毒治疗研究的尖端领域的独立计划 该申请寻求4个职位（每年2个Predoc和2个职业医生博士或MD PostDocs）。