CWRU Center for Excellence on the Impact of Substance Use on HIV

CWRU 物质使用对艾滋病毒影响卓越中心

• 批准号: 10754712
• 负责人: Alan David Levine
• 金额: $ 7.9万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754712
• 关键词: Acceleration; Acquired Immunodeficiency Syndrome; Affect; Award; Basic Science; Behavioral; Behavioral Research; Bioinformatics; Biometry; Biomimetics; Brain; Cannabis; Capital; Caring; Cell model; Cells; Cities; Clinic; Clinical; Clinical Investigator; Clinical Research; Cocaine misuse; Communities; Community Outreach; Complex; Computational Biology; County; Databases; Development; Diagnosis; Discipline; Disease; Drug usage; Education; Equipment; Exposure to; Faculty; Foundations; Functional disorder; Funding; Grant; HIV; HIV/HCV; Health; Hepatitis C co-infection; Hospitals; Immune; Immunologics; Immunosuppression; Individual; Infrastructure; International; Investigation; Leadership; Link; Medical center; Medicine; Memory impairment; Mental Health; Mentors; Methamphetamine; Methods; Modeling; Molecular; Motivation; Mucous Membrane; Myelogenous; National Institute of Drug Abuse; Neurocognitive Deficit; Neurologic; Neurological outcome; Opioid; Outcome; Pathogenesis; Patient Recruitments; Patients; Persons; Physician Executives; Positioning Attribute; Prevention Research; Prevention education; Process; Proteomics; Public Health; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Rural; Schools; Services; Social Sciences; Strategic Planning; Substance Use Disorder; Surveys; Systems Biology; Teacher Professional Development; Technology; Tissues; Translational Research; Trauma; Underserved Population; United States Department of Veterans Affairs; Universities; University Hospitals; Victimization; Violence; behavioral health intervention; behavioral outcome; biobank; career; clinical database; cocaine use; cohort; collaborative environment; comorbidity; design; experience; gastrointestinal; immune reconstitution; induced pluripotent stem cell; induced pluripotent stem cell technology; innovation; insight; interdisciplinary collaboration; lecturer; lipidomics; marijuana use; medical schools; metabolomics; methamphetamine use; microbiome; neuroAIDS; neuroinflammation; new technology; next generation; opioid use; programs; service intervention; sexual risk behavior; stem cells; substance misuse; substance use; suburb; symposium; synergism; three-dimensional modeling; transcriptomics; violence prevention

Project Summary - Overview The newly developed CWRU (Case Western Reserve University) Center for Excellence on the Impact of Substance Use on HIV was conceived in August 2017 and was initiated to effectively promote excellence in basic, translational, and clinical research concerning the intersection between substance use and HIV. The Center for Excellence includes 12 NIDA-funded Investigators who collectively hold 9 R01, 2 DP1, 3 R34, 2 R44, 1 U01, and 2 K01 drawn from the CWRU School of Medicine, University Hospitals Cleveland Medical Center, MetroHealth Medical Center, the Cleveland Clinic Foundation, the Louis Stokes Cleveland Veterans Administration Medical Center, the CWRU Mandel School of Applied Social Sciences, the Begun Center for Violence Prevention Research and Education, and the Cuyahoga County, Lorain County, and City of Cleveland Departments of Health. Major research strengths in the Center for Excellence include impact of drug use on HIV immunopathogenesis, HIV latency and Cure, NeuroAIDS, gastrointestinal dysfunction, sexual risk behavior, and HIV and HCV co-infections. Our studies are anchored by advanced computational, systems biology, biomimetic models, and induced pluripotent stem cell (iPSC) technologies that provide the opportunity to perform meta-omics analyses of the impact of opioid, methamphetamine, cannabis, and cocaine misuse on several clinical, virological, immunological, behavioral, and neurological outcomes of HIV disease. The Center for Excellence has the following Specific Aims: • Provide scientific leadership to position the Center at the forefront of substance use disorder research and function as a national research resource for the study of drug use in persons with HIV. • Establish an administrative infrastructure that maintains fiscal and management oversight of the Cores. • Apply advanced Computational Biology, Primary Cells, Biomimetic models, and iPSC- derived Cells to study of the impact of substance use on HIV disease. • Support translational, clinical, and behavioral research through access to unique clinical cohorts of persons with substance use disorder with HIV and at risk for HIV. • Accelerate junior faculty development and encourage experienced faculty to enter the substance use research arena to support the next generation of investigators. • Participate in community outreach.

项目摘要 - 概述 新开发的 CWRU（凯斯西储大学）卓越中心 物质使用对艾滋病毒的影响于 2017 年 8 月构思并启动，以有效地 促进有关两者交叉点的基础、转化和临床研究的卓越性 物质使用和艾滋病毒。卓越中心包括 12 名 NIDA 资助的研究人员，他们 总共拥有 9 R01、2 DP1、3 R34、2 R44、1 U01 和 2 K01，均来自 CWRU 学院 医学，大学医院克利夫兰医学中心，MetroHealth 医疗中心，克利夫兰 诊所基金会、路易斯斯托克斯克利夫兰退伍军人管理局医疗中心、CWRU 曼德尔应用社会科学学院，暴力预防研究中心 教育部，以及凯霍加县、洛雷恩县和克利夫兰市卫生部。 卓越中心的主要研究优势包括吸毒对艾滋病毒的影响 免疫发病机制、HIV 潜伏期和治愈、神经艾滋病、胃肠功能障碍、性风险 行为以及 HIV 和 HCV 合并感染。我们的研究以先进的计算为基础， 系统生物学、仿生模型和诱导多能干细胞 (iPSC) 技术 提供对阿片类药物、甲基苯丙胺、 大麻和可卡因滥用对一些临床、病毒学、免疫学、行为学和 HIV 疾病的神经学结果。卓越中心有以下具体目标： • 提供科学领导，使中心处于药物使用的前沿 疾病研究和作为药物使用研究的国家研究资源的功能 艾滋病毒感染者。 • 建立维持财政和管理监督的行政基础设施 的核心。 • 应用先进的计算生物学、原代细胞、仿生模型和 iPSC- 衍生细胞来研究物质使用对艾滋病毒疾病的影响。 • 通过获取独特的临床数据支持转化、临床和行为研究 患有艾滋病毒物质使用障碍且有感染艾滋病毒风险的人群。 • 加速初级教师的发展并鼓励有经验的教师进入 物质使用研究领域支持下一代研究人员。 • 参与社区外展活动。