Administrative Core A

项目摘要核心A--行政核心 CWRU药物使用对艾滋病毒管理的影响卓越中心 CORE负责推动我们机构在艾滋病毒研究中使用物质的方向 通过响应中心研究人员不断变化的研究需求。行政部门 核心提供领导和组织结构，以协调、支持和增强 中心成员的努力，并对科学fic，行政， 中心的预算、业务和业务方面。该中心的主要优势包括 科技创新和专业知识，以实现我们的四个主要目标 研究物质使用对艾滋病毒的影响： (1)甲基苯丙胺、艾滋病毒和免疫抑制对神经认知障碍的影响； 由于神经胶质细胞活化、氧化应激、星形胶质细胞增生症、神经炎症和艾滋病毒 重新激活。 (2)可卡因和艾滋病毒对小胶质细胞额叶-纹状体多巴胺回路的失调， 推动动机障碍的进展并增加对 艾滋病毒和有利于艾滋病毒复制和潜伏期。 (Iii)阿片类药物和艾滋病毒对病毒复制、病毒介导的病理、血-脑- 屏障、免疫抑制、病毒潜伏和病毒反弹。 (4)大麻和艾滋病毒的兴奋作用，在低剂量下抗炎，限制艾滋病毒 病毒复制和减轻艾滋病毒相关的免疫抑制和炎症， 在高剂量或慢性剂量下，与灰质体积和 记忆缺陷。 行政核心A制定了前瞻性战略规划程序， 包括来自中心成员和领导层以及机构行政部门的意见 人事部。战略计划的实施包括：(A)组织、管理和 宣传研究支助核心，(B)获得和有效利用机构资金，以 通过新的研究进一步投资于初级和代表性不足的医学研究人员 在团队科学背景下的方案，(C)实行财政限制和增加外部资金， (D)开展教育、政策和外联活动，充分吸引中心调查人员的参与 和地方卫生部门公布的，(E)公平适用，广为人知，达成一致 评估。中央行政核心A的具体目标是： ·协调和实施严格的年度审查和战略规划进程。 ·利用机构支持来加强我们机构的物质使用研究。 ·为了支持我们在系统生物学和大数据收集领域的重要足迹， 管理、存储和分析。 ·在全国各地鼓励培训、教育和社区外联活动 卓越中心。 ·改善整个中心的沟通，并监督负责任、严格、 和可重复的研究活动。 ·作为艾滋病毒研究领域药物使用方面的国家研究资源。

Project Summary Core A – Administrative Core The CWRU Center for Excellence on the Impact of Substance Use on HIV Administrative Core is responsible for driving the direction of Substance Use in HIV research at our institutions by being responsive to the evolving research needs of Center investigators. The Administrative Core provides the leadership and organizational structure to coordinate, support, and enhance the efforts of the Center members and bears responsibility for the scientific, administrative, budgetary, and operational aspects of the Center. The major strengths of the Center include scientific and technological innovation and expertise to pursue our four main objectives in studying the impact of Substance Use on HIV: (i) Methamphetamine & HIV and immunosuppression on neurocognitive impairment, due to glial activation, oxidative stress, astrocyte gliosis, neuroinflammation, and HIV reactivation. (ii) Cocaine & HIV dysregulation of the fronto-striatal dopamine circuit in microglia, driving the progression of motivational dysfunction and increasing susceptibility to HIV and favoring HIV replication and latency. (iii) Opioid & HIV modulation of viral replication, virus-mediated pathology, blood-brain- barrier, immunosuppression, viral latency, and viral rebound. (iv) Hormetic effect of Cannabis & HIV, as anti-inflammatory at low doses, limiting HIV viral replication and attenuating HIV-related immunosuppression and inflammation, and at high or chronic doses, associating with reduced gray matter volume and memory deficits. The Administrative Core A has developed a forward-looking Strategic Planning process that includes input from Center members and leadership, as well as institutional administrative personnel. Implementation of the Strategic Plan includes (a) organizing, managing, and advertising the Research Support Cores, (b) obtaining and effectively using institutional funds to further invest in junior and underrepresented investigators in medicine with novel research programs in a team science setting, (c) exercise fiscal constraint and advance external funding, (d) develop educational, policy, and outreach activities that fully engage Center investigators and local departments of publish health, and (e) fairly apply well-publicized, agreed upon evaluations. The Specific Aims for the Center Administrative Core A are: • To coordinate and implement a rigorous annual review and strategic planning process. • To leverage institutional support to enhance Substance Use research at our institutions. • To support our significant footprint in systems biology and ‘big data’ collection, management, storage, and analysis. • To stimulate training, educational, and community outreach activities throughout the Center for Excellence. • To improve communications throughout the Center and oversee responsible, rigorous, and reproducible research activities. • To serve as national research resource in the drug use in HIV research field.