Tri-Institutional PhD Program in Chemical Biology

化学生物学三机构博士项目

• 批准号: 10414800
• 负责人: DEREK S TAN
• 金额: $ 31.22万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10414800
• 关键词: Biology; Chemicals; Doctor of Philosophy; programs

PROJECT SUMMARY Tri-Institutional PhD Program in Chemical Biology (TPCB) The Tri-Institutional PhD Program in Chemical Biology (TPCB) is an innovative graduate program that provides students with comprehensive training at the interface of chemistry, biology, and medicine. TPCB is unique in that it is offered jointly by three premier research institutions with adjacent campuses in the heart of New York City: Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medical College. This stand-alone, direct admission graduate program was established in 2001 as one of the first in the nation to focus specifically on training the next generation of chemical biology researchers. Over the last 19 years, TPCB has established itself as a leading graduate program in chemical biology, with 70 PhD graduates and 43 current students (26 training grant-eligible, TGE). Students come from both chemical and biological backgrounds and the program combines quantitative chemical training with deep insights into forefront problems in biomedical research. Students also come from a wide range of scientific and cultural backgrounds and this diversity is celebrated. The program welcomes students from underrepresented minority groups, those with disabilities, and those from disadvantaged socioeconomic backgrounds (currently totaling 35% of TGE) and works with each student individually to ensure they have the resources necessary to thrive. The curriculum includes two chemical biology courses created specifically for TPCB students, additional core and elective courses, a seminar course, lab rotations, student Research-in-Progress seminars, annual student- organized Tri-I Chemical Biology Symposium and TPCB Student Career Development Retreat, and the Sanders Tri-I Chemical Biology Seminar Series. Students receive extensive career development training and formal ongoing instruction in Responsible Conduct of Research and Rigor & Reproducibility. Students have opportunities to conduct PhD thesis research with 54 dedicated faculty mentors working across the spectrum of chemical biology with >$1M average annual funding. Students move seamlessly between the three institutions and have access to the state-of-the-art research facilities and rich scientific environment on all three campuses, providing diverse opportunities to pursue fundamental and translational research and to engage in multidisciplinary collaborations. Importantly, TPCB students are deeply involved in the organization and design of the training experience, and the program has evolved continually in response to student feedback. As a result, TPCB students have been exceptionally productive, publishing over 400 scientific papers (average 5.2 papers/graduate), graduating in an average of 5.5 years. TPCB alumni have continued onto a wide range of successful careers across the tenure track (17%), pharma (12%), biotech (29%), other labs (10%), and research-related careers (31%). TPCB receives strong institutional support but is still unable to admit all of the qualified candidates who apply. Thus, this NIGMS Chemistry–Biology Interface T32 training grant will enable further growth and enhancement of this successful training program and its broader impacts on the community.

项目概要 化学生物学三机构博士项目（TPCB） 化学生物学三机构博士项目（TPCB）是一个创新的研究生项目， 为学生提供化学、生物学和医学交叉领域的全面培训。 TPCB是 其独特之处在于它由位于市中心的三个一流研究机构联合提供 纽约市：纪念斯隆凯特琳癌症中心、洛克菲勒大学和威尔康奈尔大学 医学院。这个独立的、直接录取的研究生项目成立于 2001 年，是 在全国第一个专门专注于培养下一代化学生物学研究人员。 在过去的 19 年里，TPCB 已成为化学生物学领域领先的研究生项目，拥有 70 博士毕业生和 43 名在校学生（26 名符合培训补助金资格，TGE）。学生来自化学 和生物学背景，该计划将定量化学培训与深入洞察结合起来 生物医学研究的前沿问题。学生也来自广泛的科学和文化领域 背景和这种多样性是值得庆祝的。该计划欢迎来自少数族裔的学生 群体、残疾人和社会经济背景不利的群体（目前总计 TGE 的 35%）并与每个学生单独合作，以确保他们拥有成长所需的资源。 该课程包括两门专门为 TPCB 学生创建的化学生物学课程、额外的核心课程 和选修课程、研讨会课程、实验室轮换、学生正在进行的研究研讨会、年度学生- 组织了 Tri-I 化学生物学研讨会和 TPCB 学生职业发展静修会，以及 Sanders Tri-I 化学生物学研讨会系列。学生接受广泛的职业发展培训 负责任的研究行为以及严谨性和可重复性方面的正式持续指导。学生有 与 54 名跨领域专业教师导师一起进行博士论文研究的机会 化学生物学领域的平均年资助额超过 100 万美元。学生在三个机构之间无缝流动 并可以使用这三个领域最先进的研究设施和丰富的科学环境 校园，提供各种机会进行基础和转化研究并参与 多学科合作。重要的是，TPCB的学生深入参与了组织和设计 培训经验的积累，并且该计划根据学生的反馈不断发展。 结果，TPCB 学生的生产力异常高，发表了 400 多篇科学论文（平均 5.2篇论文/研究生），平均毕业时间5.5年。 TPCB 校友继续涉足广泛的领域 终身教职 (17%)、制药 (12%)、生物技术 (29%)、其他实验室 (10%) 和 研究相关职业（31%）。 TPCB获得了强有力的机构支持，但仍无法承认所有的 申请的合格候选人。因此，NIGMS 化学-生物接口 T32 培训补助金将使 进一步发展和加强这一成功的培训计划及其对社区的更广泛影响。