Tri-Institutional PhD Program in Chemical Biology

化学生物学三机构博士项目

• 批准号: 10618939
• 负责人: DEREK S TAN
• 金额: $ 31.83万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618939
• 关键词: Biology; Chemicals; Doctor of Philosophy; Institution; programs

PROJECT SUMMARY Tri-Institutional PhD Program in Chemical Biology (TPCB) The Tri-Institutional PhD Program in Chemical Biology (TPCB) is an innovative graduate program that provides students with comprehensive training at the interface of chemistry, biology, and medicine. TPCB is unique in that it is offered jointly by three premier research institutions with adjacent campuses in the heart of New York City: Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medical College. This stand-alone, direct admission graduate program was established in 2001 as one of the first in the nation to focus specifically on training the next generation of chemical biology researchers. Over the last 19 years, TPCB has established itself as a leading graduate program in chemical biology, with 70 PhD graduates and 43 current students (26 training grant-eligible, TGE). Students come from both chemical and biological backgrounds and the program combines quantitative chemical training with deep insights into forefront problems in biomedical research. Students also come from a wide range of scientific and cultural backgrounds and this diversity is celebrated. The program welcomes students from underrepresented minority groups, those with disabilities, and those from disadvantaged socioeconomic backgrounds (currently totaling 35% of TGE) and works with each student individually to ensure they have the resources necessary to thrive. The curriculum includes two chemical biology courses created specifically for TPCB students, additional core and elective courses, a seminar course, lab rotations, student Research-in-Progress seminars, annual student- organized Tri-I Chemical Biology Symposium and TPCB Student Career Development Retreat, and the Sanders Tri-I Chemical Biology Seminar Series. Students receive extensive career development training and formal ongoing instruction in Responsible Conduct of Research and Rigor & Reproducibility. Students have opportunities to conduct PhD thesis research with 54 dedicated faculty mentors working across the spectrum of chemical biology with >$1M average annual funding. Students move seamlessly between the three institutions and have access to the state-of-the-art research facilities and rich scientific environment on all three campuses, providing diverse opportunities to pursue fundamental and translational research and to engage in multidisciplinary collaborations. Importantly, TPCB students are deeply involved in the organization and design of the training experience, and the program has evolved continually in response to student feedback. As a result, TPCB students have been exceptionally productive, publishing over 400 scientific papers (average 5.2 papers/graduate), graduating in an average of 5.5 years. TPCB alumni have continued onto a wide range of successful careers across the tenure track (17%), pharma (12%), biotech (29%), other labs (10%), and research-related careers (31%). TPCB receives strong institutional support but is still unable to admit all of the qualified candidates who apply. Thus, this NIGMS Chemistry–Biology Interface T32 training grant will enable further growth and enhancement of this successful training program and its broader impacts on the community.

项目摘要 化学生物学三机构博士课程（TPCB） 在化学生物学三机构博士课程（TPCB）是一个创新的研究生课程， 为学生提供化学，生物和医学方面的综合培训。TPCB是 独特的是，它是由三个首屈一指的研究机构与相邻的校园在心脏联合提供的， 纽约市：纪念斯隆凯特琳癌症中心，洛克菲勒大学和威尔康奈尔大学 医学院这个独立的，直接录取的研究生课程成立于2001年，是 在全国率先专门培养下一代化学生物学研究人员。 在过去的19年里，TPCB已经成为化学生物学领域领先的研究生课程，拥有70 博士毕业生和43名在校生（26名符合培训补助金条件，TGE）。学生来自两个化学 和生物背景，该计划将定量化学培训与深入了解 生物医学研究的前沿问题。学生还来自广泛的科学和文化领域 背景和这种多样性是庆祝。该计划欢迎来自代表性不足的少数民族的学生 残疾人和来自弱势社会经济背景的人（目前 TGE的35%），并与每个学生单独工作，以确保他们有必要茁壮成长的资源。 该课程包括两门专门为TPCB学生创建的化学生物学课程， 和选修课程，研讨会课程，实验室轮换，学生研究进展研讨会，每年的学生- 组织了三-I化学生物学研讨会和TPCB学生职业发展务虚会，以及 Sanders Tri-I化学生物学研讨会系列。学生接受广泛的职业发展培训， 在负责任的研究行为和严谨性和再现性方面的正式持续指导。学生 有机会进行博士论文研究与54个专门的教师导师在整个频谱的工作 化学生物学，平均每年资助超过100万美元。学生在三所学校之间无缝衔接 并且可以使用这三个国家最先进的研究设施和丰富的科学环境 校园，提供多样化的机会，追求基础和转化研究，并从事 多学科合作。重要的是，TPCB学生深入参与组织和设计 培训经验，该计划已不断发展，以回应学生的反馈。 因此，TPCB的学生非常富有成效，发表了400多篇科学论文（平均 5.2论文/毕业生），平均毕业时间为5.5年。TPCB校友继续在广泛的 在终身教职（17%）、制药（12%）、生物技术（29%）、其他实验室（10%）和 与研究相关的职业（31%）。TPCB得到了强有力的机构支持，但仍然无法接纳所有 符合条件的申请人。因此，这个NIGMS化学生物学接口T32培训补助金将使 进一步发展和加强这一成功的培训方案及其对社区的更广泛影响。

项目成果

Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins.

• DOI: 10.1016/j.jbc.2023.104664
• 发表时间: 2023-05
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Kotliar, Ilana B.;Ceraudo, Emilie;Kemelmakher-Liben, Kevin;Oren, Deena A.;Lorenzen, Emily;Dodig-Crnkovic, Tea;Horioka-Duplix, Mizuho;Huber, Thomas;Schwenk, Jochen M.;Sakmar, Thomas P.
• 通讯作者: Sakmar, Thomas P.

Students' Perspective on Scientific Training.

学生对科学训练的看法。

• DOI: 10.1002/cbic.202300054
• 发表时间: 2023
• 期刊: Chembiochem : a European journal of chemical biology
• 作者: Chua,GabriellaNL;Vandana,JJeya;Hsieh,Chun-Cheng
• 通讯作者: Hsieh,Chun-Cheng

Genetic code expansion to enable site-specific bioorthogonal labeling of functional G protein-coupled receptors in live cells.

• DOI: 10.1002/pro.4550
• 发表时间: 2023-02
• 期刊: PROTEIN SCIENCE
• 影响因子: 8
• 作者: Mattheisen, Jordan M.;Wollowitz, Jaina S.;Huber, Thomas;Sakmar, Thomas P.
• 通讯作者: Sakmar, Thomas P.

Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins.

• DOI: 10.1124/pharmrev.120.000180
• 发表时间: 2023-01
• 期刊: Pharmacological reviews
• 影响因子: 21.1

Detection of SARS-CoV-2 RNA Using a DNA Aptamer Mimic of Green Fluorescent Protein.

• DOI: 10.1021/acschembio.1c00893
• 发表时间: 2022-04-15
• 期刊: ACS CHEMICAL BIOLOGY
• 影响因子: 4
• 作者: VarnBuhler, Bria S.;Moon, Jared;Dey, Sourav Kumar;Wu, Jiahui;Jaffrey, Samie R.
• 通讯作者: Jaffrey, Samie R.