Comparative Pathology Core

脊椎动物模型的使用是必不可少的，以回答基本问题，阐明机制， 环境暴露可通过其影响人类疾病并产生不利的人类健康 健康成果。多种动物模型，如斑马鱼、青鳉鱼、小鼠、大鼠、兔、豚鼠、田鼠， 爪蟾，家养动物（狗，猪，羊等）其他人，沿着他们的基因工程 对应物，代表了将分子机制与病理损伤联系起来的强大体内方法 （破坏器官/组织功能）和毒性作用。动物模型仍然是研究这些的黄金标准 环境毒物对发育、癌症、生殖、器官毒性和神经和 内分泌系统这些方法是强大的，因为体内模型生物体在一个系统中运行 生物学框架整合了所有层次的生物组织-生物分子，途径，细胞，组织，器官， 和有机体-并告知我们潜在的不利人类健康后果。了解这些不利因素 需要对受影响的组织/器官/细胞进行专家病理学评估。为了满足这一需求， 比较病理学核心（CPC）是为CHHE成员科学家提供免费的 病理学专业知识，以评估各种动物模型中环境因素的影响。

Vertebrate animal model use is essential to answer fundamental questions and elucidate the mechanisms in vivo through which environmental exposures may influence human disease and produce adverse human health outcomes. Diverse animal models, such as zebrafish, medaka fish, mouse, rat, rabbit, guinea pig, vole, xenopus, domestic animal (dogs, pigs, sheep, etc.) and others, along with their genetically engineered counterparts, represent powerful in vivo approaches to link molecular mechanisms to pathologic lesions (disrupted organ/tissue function) and toxic effects. Animal models remain the gold standard for studying these effects of environmental toxicants on development, cancer, reproduction, organ toxicity, and neurological and endocrine systems. These approaches are powerful because in vivo model organisms operate in a systems biology framework integrating all levels of biological organization - biomolecule, pathway, cell, tissue, organ, and organism - and inform us of potential adverse human health outcomes. Understanding these adverse effects requires expert pathologic evaluation of the affected tissue/organ/cells. To fill this need, the mission of the Comparative Pathology Core (CPC) is to provide CHHE member scientists dedicated access to cost-free pathology expertise to assess the effects of environmental factors in a diverse range of animal models.