Comparative Pathology Core

脊椎动物模型的使用对于回答基本问题和阐明 活体，通过环境暴露可能影响人类疾病并产生对人类不利的 健康结果。各种动物模型，如斑马鱼、青花鱼、小鼠、大鼠、兔子、豚鼠、田鼠、 非洲爪哇，家养动物(狗、猪、羊等)和其他人，以及他们的基因工程 代表了将分子机制与病理损害联系起来的强大的体内方法 (器官/组织功能受损)和毒性影响。动物模型仍然是研究这些疾病的黄金标准 环境毒物对发育、癌症、生殖、器官毒性和神经功能的影响 内分泌系统。这些方法是强大的，因为体内的模型生物在一个系统中运行 整合所有层次生物组织的生物框架-生物分子、途径、细胞、组织、器官 和生物体--并告知我们潜在的对人类健康不利的后果。了解这些不利因素 影响需要专家对受影响的组织/器官/细胞进行病理评估。为了满足这一需求， 比较病理学的核心(CPC)是为CHHE成员科学家提供免费获取 在各种动物模型中评估环境因素影响的病理学专业知识。

Vertebrate animal model use is essential to answer fundamental questions and elucidate the mechanisms in vivo through which environmental exposures may influence human disease and produce adverse human health outcomes. Diverse animal models, such as zebrafish, medaka fish, mouse, rat, rabbit, guinea pig, vole, xenopus, domestic animal (dogs, pigs, sheep, etc.) and others, along with their genetically engineered counterparts, represent powerful in vivo approaches to link molecular mechanisms to pathologic lesions (disrupted organ/tissue function) and toxic effects. Animal models remain the gold standard for studying these effects of environmental toxicants on development, cancer, reproduction, organ toxicity, and neurological and endocrine systems. These approaches are powerful because in vivo model organisms operate in a systems biology framework integrating all levels of biological organization - biomolecule, pathway, cell, tissue, organ, and organism - and inform us of potential adverse human health outcomes. Understanding these adverse effects requires expert pathologic evaluation of the affected tissue/organ/cells. To fill this need, the mission of the Comparative Pathology Core (CPC) is to provide CHHE member scientists dedicated access to cost-free pathology expertise to assess the effects of environmental factors in a diverse range of animal models.