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High-Definition Conformal Electronics for VT/VF

适用于 VT/VF 的高清保形电子器件

基本信息

批准号：
10661291
负责人：
IGOR R EFIMOV
金额：
$ 62.33万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-10 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10661291
关键词：
Address Adopted Algorithms Arrhythmia Canis familiaris Cardiovascular system Cessation of life Development Device Designs Devices Diagnostic Dissociation Economics Electric Countershock Electric Stimulation Therapy Electronics Filament Frequencies Future Generations Goals Healthcare Healthcare Systems Heart Hospitals Human Implantable Defibrillators Individual Knowledge Laboratories Lead Location Measures Methods Modeling Myocardial Infarction Optics Organ Oryctolagus cuniculus Pain Patients Phase Prevention Quality of life Research Personnel Resolution Shock Tachycardia Technology Testing Therapeutic Time Transillumination Treatment Efficacy United States Ventricular Ventricular Arrhythmia Ventricular Fibrillation Ventricular Tachycardia Work base care burden comorbidity effective therapy experimental study implantable device improved in vivo individual patient individualized medicine innovation insight myocardial damage novel novel strategies prediction algorithm psychological distress public health relevance sensor side effect sudden cardiac death

项目摘要

Project Summary/Abstract Ventricular arrhythmias including ventricular tachycardia (VT) and ventricular fibrillation (VF) are responsible for 300,000 sudden cardiac deaths a year in the US. Electrotherapy has been effective in arresting VT/VF but the high-energy biphasic shocks can lead to myocardial damage and associated co-morbidities. Moreover the implantable cardioverter defibrillator technology (ICD) has low VT/VF sensing resolution, which can lead to inappropriate shocks and associated psychological distress, resulting in diminished quality of life or even death. Thus, there is an unmet need for high-definition VT/VF sensing to reduce inappropriate shocks and similarly, an unmet need for high-definition ultra-low energy electrotherapy to terminate VT/VF. In this project, we present a novel approach to VT/VF sensing and electrotherapy and redesign the ICD into cardiovascular implantable electronic device (CIED). We will employ two break-through technological platforms to implement our novel method: (1) A novel conformal chiplet electronics real-time networks (CCERN) technology developed by Co-Investigator Dr. Rogers and an (2) innovative panoramic, transillumination optical mapping developed by PI Dr. Efimov. We will conduct high-definition, panoramic, transillumination, optical mapping in conjunction with high-definition CCERN to (1) characterize the transmural VT/VF dynamics, (2) determine the optimal number of sensors needed to dynamically track the excitable gaps, phase singularities, and wavefronts during VT/VF, and (3) terminate VT/VF using optimal definition ultra low-energy high-definition electrotherapy. This proposed work would advance our understanding of VT/VF and pave the path towards creating a targeted individualized therapy dynamically tailored for each arrhythmia episode for each patient.

项目总结/摘要室性心律失常，包括室性心动过速（VT）和心室颤动（VF），美国每年有30万人死于心脏病电疗在阻止VT/VF方面是有效的，高能量双相电击可导致心肌损伤和相关的并发症。而且植入式心律转复除颤器技术（ICD）具有低VT/VF感测分辨率，这可能导致不适当的电击和相关的心理困扰，导致生活质量下降，甚至死亡因此，存在对高清晰度VT/VF感测以减少不适当的电击和电击刺激的未满足的需求。类似地，对高清晰度超低能量电疗终止VT/VF需求未得到满足。在这项目，我们提出了一种新的方法VT/VF传感和电疗，并重新设计ICD，心血管植入式电子设备（CIED）。我们将采用两种突破性的技术平台来实现我们的新方法：（1）一种新的共形小芯片电子学实时网络（CCERN）技术开发的共同研究员博士罗杰斯和（2）创新的全景，由PI Efimov博士开发的透照光学映射。我们将进行高清晰度，全景，透照，光学测绘结合高清晰度CCERN，以（1）表征透壁VT/VF动态，（2）确定动态跟踪VT/VF动态所需的传感器的最佳数量 VT/VF期间的可兴奋间隙、相位奇点和波前，以及（3）使用最佳的超低能量高清晰度电疗。这项拟议的工作将促进我们的了解VT/VF，并为动态创建有针对性的个性化治疗铺平道路为每位患者的每次心律失常发作量身定制。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Optical Mapping.

DOI：
10.1016/j.ccep.2019.04.004
发表时间：
2019-09-01
期刊：
Cardiac electrophysiology clinics
影响因子：
0
作者：
Berenfeld, Omer;Efimov, Igor
通讯作者：
Efimov, Igor

Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery.

DOI：
10.1038/s41551-020-00604-w
发表时间：
2020-10
期刊：
Nature biomedical engineering
影响因子：
28.1
作者：
Han M;Chen L;Aras K;Liang C;Chen X;Zhao H;Li K;Faye NR;Sun B;Kim JH;Bai W;Yang Q;Ma Y;Lu W;Song E;Baek JM;Lee Y;Liu C;Model JB;Yang G;Ghaffari R;Huang Y;Efimov IR;Rogers JA
通讯作者：
Rogers JA

Fully implantable and bioresorbable cardiac pacemakers without leads or batteries.

DOI：
10.1038/s41587-021-00948-x
发表时间：
2021-10
期刊：
NATURE BIOTECHNOLOGY
影响因子：
46.9
作者：
Choi, Yeon Sik;Yin, Rose T.;Pfenniger, Anna;Koo, Jahyun;Avila, Raudel;Benjamin Lee, K.;Chen, Sheena W.;Lee, Geumbee;Li, Gang;Qiao, Yun;Murillo-Berlioz, Alejandro;Kiss, Alexi;Han, Shuling;Lee, Seung Min;Li, Chenhang;Xie, Zhaoqian;Chen, Yu-Yu;Burrell, Amy;Geist, Beth;Jeong, Hyoyoung;Kim, Joohee;Yoon, Hong-Joon;Banks, Anthony;Kang, Seung-Kyun;Zhang, Zheng Jenny;Haney, Chad R.;Sahakian, Alan Varteres;Johnson, David;Efimova, Tatiana;Huang, Yonggang;Trachiotis, Gregory D.;Knight, Bradley P.;Arora, Rishi K.;Efimov, Igor R.;Rogers, John A.
通讯作者：
Rogers, John A.

Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation.

DOI：
10.1126/sciadv.abq7469
发表时间：
2022-10-28
期刊：
SCIENCE ADVANCES
影响因子：
13.6
作者：
Ausra, Jokubas;Madrid, Micah;Yin, Rose T.;Hanna, Jessica;Arnott, Suzanne;Brennan, Jaclyn A.;Peralta, Roberto;Clausen, David;Bakall, Jakob A.;Efimov, Igor R.;Gutruf, Philipp
通讯作者：
Gutruf, Philipp

Hardware-Mappable Cellular Neural Networks for Distributed Wavefront Detection in Next-Generation Cardiac Implants.

用于下一代心脏植入物中分布式波前检测的硬件可映射细胞神经网络。