Monitoring the hemodynamic response to therapy in diabetic retinopathy

监测糖尿病视网膜病变治疗的血流动力学反应

• 批准号: 10661730
• 负责人: Amani A Fawzi
• 金额: $ 46.55万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10661730
• 关键词: Ablation; Address; Adult; Affect; Age; Aneurysm; Angiography; Area; Automation; Blindness; Blood; Blood Flow Velocity; Blood Vessels; Blood capillaries; Blood flow; Burn injury; Cell physiology; Clinical; Clinical Trials; Collaborations; Color; Complications of Diabetes Mellitus; Computer software; Coupled; Data; Development; Diabetes Mellitus; Diabetic Retinopathy; Disease; Extravasation; Eye; Functional disorder; Goals; Hemorrhage; Image; Imaging Techniques; Individual; Interruption; Ischemia; Knowledge; Lasers; Lateral; Light Coagulation; Liquid substance; Maps; Measurement; Measures; Medical; Microaneurysm; Monitor; Natural History; Nerve Degeneration; Non-Invasive Detection; Ophthalmology; Optics; Outcome; Outcome Measure; Pathology; Patients; Performance; Perfusion; Peripheral; Pharmaceutical Preparations; Pharmacotherapy; Photography; Physiological; Reproducibility; Resolution; Retina; Retinal Hemorrhage; Scanning; Selection for Treatments; Speed; Surface; Technology; Testing; Thick; Time; Vascular Diseases; Vision; adaptive optics; adaptive optics scanning laser ophthalmoscopy; alternative treatment; clinical development; cost; density; diabetic; endothelial repair; flexibility; hemodynamics; improved; insight; macula; macular edema; meter; multimodality; non-invasive imaging; novel; novel therapeutics; optical imaging; preservation; proliferative diabetic retinopathy; quantitative imaging; response; retinal angiogenesis; retinal imaging; retinal ischemia; standard of care; success; therapy design; therapy outcome; tool; treatment response

This proposal aims to study retinal blood flow, detected by non-invasive imaging, during medical treatments for diabetic retinopathy. Success of this proposal will lead to the development of non-invasive measurements that can guide clinicians as they manage patients with sight threatening complications of diabetic retinopathy.

本提案旨在研究视网膜血流，通过非侵入性成像检测，在医疗过程中

项目成果

Macrophage-Like Cell Density Is Increased in Proliferative Diabetic Retinopathy Characterized by Optical Coherence Tomography Angiography.

• DOI: 10.1167/iovs.62.10.2
• 发表时间: 2021-08-02
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Ong JX;Nesper PL;Fawzi AA;Wang JM;Lavine JA
• 通讯作者: Lavine JA

Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.

• DOI: 10.1371/journal.pone.0259811
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ong JX;Zandi R;Fawzi AA
• 通讯作者: Fawzi AA

Deep Capillary Geometric Perfusion Deficits on OCT Angiography Detect Clinically Referable Eyes with Diabetic Retinopathy.

• DOI: 10.1016/j.oret.2022.05.028
• 发表时间: 2022-12
• 期刊: OPHTHALMOLOGY RETINA
• 影响因子: 4.5
• 作者: Nesper, Peter L.;Ong, Janice X.;Fawzi, Amani A.
• 通讯作者: Fawzi, Amani A.

The Fovea-Protective Impact of Double-Layer Sign in Eyes With Foveal-Sparing Geographic Atrophy and Age-Related Macular Degeneration.

• DOI: 10.1167/iovs.63.11.4
• 发表时间: 2022-10-03
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4

Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2.

• DOI: 10.3390/jcm9103149
• 发表时间: 2020-09-29
• 期刊: Journal of clinical medicine
• 影响因子: 3.9
• 作者: Zandi R;Song J;Micevych PS;Fawzi AA
• 通讯作者: Fawzi AA