Development of a Fully-Implantable Ventricular Assist Device for Neonates and Children with Heart Failure - with Magnetic Levitation to Improve Hemocompatibility
Development of a Fully-Implantable Ventricular Assist Device for Neonates and Children with Heart Failure - with Magnetic Levitation to Improve Hemocompatibility
批准号:
10661591
负责人:
O. H. FRAZIER
金额:
$78.79万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-08-01 至 2025-06-30
关键词:
4 year old5 year oldAbdomenAcuteAddressAdultAffectAgeAnimalsAortaBackBerlinBirthBloodBlood PressureBlood flowCause of DeathChestChildChildhoodChronicCoupledDevelopmentDevicesDiameterEnvironmentEvaluationFeasibility StudiesGeometryGrowth and Development functionHeartHeart TransplantationHeart failureHemolysisHemorrhageHospitalizationHospitalsImplantIn VitroIncidenceInfantInfectionIronLeft ventricular structureLength of StayLifeLiquid substanceLocationMagnetismMechanicsMissionMotorNational Heart, Lung, and Blood InstituteNational Institute of Biomedical Imaging and BioengineeringPatientsPerformancePhysiologicalPositioning AttributeProceduresPropertyPumpQuality of lifeRadialResearchRisk ReductionRunningSeriesSkinSpeedStrokeSurvival RateSystemTestingThoracotomyThrombosisTimeTouchdownTransplantationTubeUnited StatesUnited States National Institutes of HealthWeighing patientactive controlalternative treatmentblood pumpcongenital heart disorderdesignhemocompatibilityhemodynamicsimplantationimprovedinsightleft ventricular assist deviceneonatepatient mobilitypediatric heart failurepediatric patientspressurepreventresidenceresponseshear stresssheep modelstroke risktransplantation therapyventricular assist device
中文摘要
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英文摘要
PROJECT SUMMARY
The annual incidence of pediatric heart failure due to congenital heart disease (CHD) is 1 to 2 cases per 1000
births. Whereas 10,000 to 14,000 children are hospitalized annually in the United States waiting for a new heart,
only 444 transplants were performed in 2016, illustrating the drastic shortage of donor hearts. The only long-
term treatment alternative to a heart transplant is the implantation of a ventricular assist device (VAD), a pump
that helps the failing heart to pump blood until a new heart is available. However, these VADs are too large to
be fully implantable in children under 4 years of age; therefore, these VADs are placed externally near the
abdomen, with tubes running through the skin. These tubes can lead to infection, and they prevent the children
from leaving the hospital for the duration of pump support, which can exceed 1 year. Additionally, the survival
rate of patients weighing less than 5 kg with the currently available VADs is dismal; more than 60% of these
children die after VAD implantation, stroke being the most common cause of death. Therefore, there is a need
to design a safer, fully implantable pediatric VAD to improve the survival of both infants and young children. This
VAD also needs to be adjustable with the child’s growth and development, meaning that it must provide higher
blood flow and pressure as the child grows. The objective of this study is to develop the first fully implantable
VAD (NeoVAD) for infants and young children, which would help the failing heart until a suitable donor heart is
available. In Aim 1, development of a miniature magnetic levitation system to eliminate mechanical wear and
optimize the pump performance is proposed, which will provide a long-term circulatory support. The
hemodynamic performance of the NeoVAD in steady-state flow environments at different physiological operating
points will be investigated in Aim 2. Finally, in Aim 3, systemic hemocompatibility and hemodynamic
performance of the NeoVAD will be evaluated by in vitro and large-animal studies. This pump, after implantation,
would allow pediatric heart failure patients to return to a near-normal life outside the hospital.
This research will give new insights into designing a pump that can support the failing heart for a wide range of
patients, from infants to children weighing up to 20 kg. This wide range of support would eliminate the need to
change VADs or undergo multiple heart transplants as the child grows, both of which are risky procedures. Also,
this research will include an in-depth study of pump-blood interaction across the patient age range, allowing us
to study how blood shear stress is affected by changes in blood flow rate and pressure as the child grows. This
study will enable us to design the first safe, fully implantable VAD for young children, which would
reduce the risk of stroke, bleeding, and infection and improve their chances of survival. We expect that
with the implanted NeoVAD, pediatric CHD patients can live a near-normal life outside the hospital, which
would be a significant improvement in their quality of life.
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Numerical and Experimental Approach to Characterize a BLDC Motor with Different Radial-gap to Improve Hemocompatibility Performance.
用于表征具有不同径向间隙的 BLDC 电机以提高血液相容性性能的数值和实验方法。
DOI:
10.1109/embc44109.2020.9175989
发表时间:
2020
期刊:
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子:
--
作者:
[Wang,Yaxin, Karnik,Shweta, Smith,PAlex, Elgalad,Abdelmotagaly, Frazier,OH, Kurita,Nobuyuki]
通讯作者:
Kurita,Nobuyuki
Blood-contacting magnetic levitation bearing design using computational fluid dynamics for haemocompatibility.
使用计算流体动力学实现血液相容性的血液接触磁悬浮轴承设计。
DOI:
10.1109/embc40787.2023.10341056
发表时间:
2023
期刊:
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子:
--
作者:
[Nissim,Lee, Karnik,Shweta, Kiang,Simon, Tedesco,Victor, Ogiwara,Eiji, Kurita,Nobuyuki, Wang,Yaxin, Frazier,OHoward, Fraser,KatharineH]
通讯作者:
Fraser,KatharineH
Personalized Numerical Cardiovascular Model with Weight Growth for Evaluating Pediatric Left Ventricular Assist Devices: Derivation from an Experimental Mock Circulatory Loop.
用于评估儿科左心室辅助装置的具有体重增长的个性化数字心血管模型:源自实验模拟循环回路。
DOI:
10.1007/s10439-023-03376-x
发表时间:
2024
期刊:
Annals of biomedical engineering
影响因子:
3.8
作者:
[Tran,Phong, Tedesco,Victor, Kiang,Simon, Karnik,Shweta, Nguyen,David, Frazier,OH, Fraser,KatharineH, Wang,Yaxin]
通讯作者:
Wang,Yaxin
Numerical and Experimental Analysis for a Magnetic Levitation System in a Hemocompatibility Assessment Platform.
血液相容性评估平台中磁悬浮系统的数值和实验分析。
DOI:
10.1109/embc48229.2022.9870994
发表时间:
2022
期刊:
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子:
--
作者:
[Tedesco,Victor, Kiang,Simon, Karnik,Shweta, Smith,PAlex, Nissim,Lee, Fraser,KatherineH, Kurita,Nobuyuki, Frazier,OH, Wang,Yaxin]
通讯作者:
Wang,Yaxin
Dissipated energy and efficiency as objective functions for the design of the NeoVAD rotary blood pump.
将耗散能量和效率作为 NeoVAD 旋转式血泵设计的目标函数。
DOI:
10.1109/embc40787.2023.10340919
发表时间:
2023
期刊:
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子:
--
作者:
[Nissim,Lee, Karnik,Shweta, Smith,PAlex, Wang,Yaxin, Fraser,KatharineH]
通讯作者:
Fraser,KatharineH
共 8 条
Development of a Fully-Implantable Ventricular Assist Device for Neonates and Children with Heart Failure - with Magnetic Levitation to Improve Hemocompatibility
-
批准号:10418720
-
项目类别:
-
资助金额:$68.72万
-
财政年份:2020
-
负责人:O. H. FRAZIER
-
依托单位:
Development of a Fully-Implantable Ventricular Assist Device for Neonates and Children with Heart Failure - with Magnetic Levitation to Improve Hemocompatibility
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批准号:10029559
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项目类别:
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资助金额:$74.76万
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财政年份:2020
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负责人:O. H. FRAZIER
-
依托单位:
Development of a Fully-Implantable Ventricular Assist Device for Neonates and Children with Heart Failure - with Magnetic Levitation to Improve Hemocompatibility
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批准号:10223928
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项目类别:
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资助金额:$64.01万
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财政年份:2020
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负责人:O. H. FRAZIER
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依托单位:
Effects of a Pulse Induced by a Constant-Flow Total Cardiac Replacement Device
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批准号:8098975
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项目类别:
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资助金额:$80.68万
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财政年份:2009
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负责人:O. H. FRAZIER
-
依托单位:
Effects of a Pulse Induced by a Constant-Flow Total Cardiac Replacement Device
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批准号:7735978
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项目类别:
-
资助金额:$82.64万
-
财政年份:2009
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负责人:O. H. FRAZIER
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依托单位:
Effects of a Pulse Induced by a Constant-Flow Total Cardiac Replacement Device
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批准号:7916554
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项目类别:
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资助金额:$79.25万
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财政年份:2009
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负责人:O. H. FRAZIER
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依托单位:
A Novel Approach to Cardiac Replacement with Continuous Flow Pumps
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批准号:7466204
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项目类别:
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资助金额:$71.17万
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财政年份:2008
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负责人:O. H. FRAZIER
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依托单位:
A Novel Approach to Cardiac Replacement with Continuous Flow Pumps
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批准号:7620385
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项目类别:
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资助金额:$68.39万
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财政年份:2008
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负责人:O. H. FRAZIER
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依托单位:
A Novel Approach to Cardiac Replacement with Continuous Flow Pumps
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批准号:7860659
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项目类别:
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资助金额:$66.98万
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财政年份:2008
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负责人:O. H. FRAZIER
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依托单位:
海外基金