A longitudinal study of traumatic brain injury in a high-risk population

高危人群创伤性脑损伤的纵向研究

• 批准号: 10676267
• 负责人: KENT A KIEHL
• 金额: $ 69万
• 依托单位: LOVELACE BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-04 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676267
• 关键词: Acceleration; Address; African American; Age; Algorithms; Behavior; Brain; Brain Injuries; Chronology; Classification; Clinical; Clinical assessments; Cognitive; Communities; Consent; Data; Data Set; Databases; Dementia; Detection; Diagnosis; Diffusion; Ethnic Origin; Evaluation; Female; Follow-Up Studies; Forensic Medicine; Functional disorder; Funding; Future; General Population; Health; Hispanic; Image; Impaired cognition; Impairment; Imprisonment; Individual; Injury; Institution; Laboratories; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mental Depression; Minority Groups; Modeling; National Institute of Neurological Disorders and Stroke; Native Americans; Neurocognitive; Neurocognitive Deficit; Neurodegenerative Disorders; Neuropsychology; Outcome; Participant; Pathologic Processes; Pathology; Phenotype; Population; Process; Protocols documentation; Public Health; Race; Recording of previous events; Reproducibility; Research; Research Personnel; Resources; Risk; Risk Factors; Risk Taking; Sampling; Secure; Severities; Specific qualifier value; Substance abuse problem; Testing; Time; Traumatic Brain Injury; Twin Multiple Birth; Underserved Population; United States National Institutes of Health; Woman; Work; aged; behavior prediction; behavioral outcome; brain based; classification algorithm; comorbidity; data sharing; ethnic diversity; follow-up; high risk population; improved; independent component analysis; longitudinal dataset; male; men; mild cognitive impairment; mild traumatic brain injury; multimodal neuroimaging; neuroimaging; neuroimaging marker; offender; pediatric trauma; predictive modeling; psychopathic personality; sex; social; substance use; tool

Project Summary/Abstract Traumatic brain injury (TBI) is a global concern that precipitates a diverse set of health consequences. TBI is a major concern in forensic populations -- an issue recently highlighted by calls for research by national public health institutions [1]. Indeed, upwards of 60% of inmates have a history of TBI, a rate seven times higher than the general population (8.5%) [2, 3]. TBI is a criminogenic risk factor [3, 4] and even mild TBI increases the rates of risk-taking behavior, substance use, and future offending [2, 4]. Over the last decade our team has been continuously funded by NIH to collect detailed clinical and neuroimaging protocols from over 4000 incarcerated men and women. We utilize a unique pair of twin mobile MRI units that are deployed directly on the secure grounds of forensic facilities, making it possible to conduct this research. Our dataset includes multimodal neuroimaging protocols, thorough clinical assessment, neuropsychological evaluations, and histories of TBI. All of our n>4000 offenders have consented to participate in longitudinal follow-up studies. For this project, we will commence a longitudinal study on n=300 individuals aged 35+, examining variables that will differentiate trajectories associated with cognitive impairments. We will also leverage advanced neuroimaging tools developed by our team to provide brain-based measures of cognitive decline and imaging-based classification tools for identifying brain injuries and comorbid conditions (i.e., substance abuse, psychopathy scores, depression, etc.). We will also examine how the brain injury profiles and comorbid conditions change over time. The availability of these unique resources to examine this highly underserved population makes this an exciting project with the potential to break new ground in our understanding of individual risk needs and divergent outcomes in TBI and neurodegenerative disease.

项目总结/文摘