Interdisciplinary Training in Genome Sciences

基因组科学跨学科培训

• 批准号: 10700873
• 负责人: Bruce Colston Trapnell
• 金额: $ 79.17万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700873
• 关键词: Training; genome sciences

ABSTRACT We request funds to continue the interdisciplinary training program in genomics at the University of Washington and affiliated institutions. The program focuses on preparing pre- and postdoctoral trainees for a research career in genomics and computational biology with an emphasis on translational research. Trainees will engage in projects that include discovering how a genome encodes the information for RNAs, proteins and its own structure and replication; measuring and analyzing sequence variation; developing technologies for high-throughput experimental assays including-next generation sequencing; and generating computational tools to analyze genomic variants and their impact on mRNA and protein function. As these research challenges demand interdisciplinary approaches and multidisciplinary collaborations, one goal of this program is to attract individuals trained in computer science, statistics, physics, and engineering to biological research. Another goal is to train cellular and molecular biologists to incorporate genomic- based quantitative analyses in their research to allow them to effectively collaborate at this interdisciplinary interface. Given the wide diversity in educational backgrounds and career goals among our trainees, the program emphasizes highly individualized training programs and interdisciplinary research. A multidisciplinary group of 51 faculty, selected for their involvement in genome analysis and their strong record of collaborative interactions, comprises the training team. Research experience is complemented with a variety of didactic courses and electives. The trainees are also exposed to discussions on ethical research conduct and the ethical, legal, and social implications of genomic research. Breadth of knowledge and program cohesion are achieved through trainee participation in two seminar series that feature genomic research and computational biology, journal clubs, and research reports. In the coming five years, we will continue to expand our program in genomics, proteomics, instrumentation development, computational biology, and statistical genomics. We request funds to train 12 predoctoral and 4 postdoctoral fellows per year. The trainees will emerge with the skills necessary for success in the academic and biomedical research environment of the 21st century made possible by advances in genomics.

摘要 我们要求资金继续在基因组学的跨学科培训计划在大学 华盛顿及其附属机构。该计划的重点是准备前和博士后学员， 从事基因组学和计算生物学的研究，重点是转化研究。 学员将参与的项目包括发现基因组如何编码RNA的信息， 蛋白质及其自身的结构和复制;测量和分析序列变异;开发 用于高通量实验测定的技术，包括下一代测序;以及 生成计算工具来分析基因组变异及其对mRNA和蛋白质功能的影响。 由于这些研究挑战需要跨学科的方法和多学科的合作， 该计划的目标是吸引在计算机科学，统计学，物理学和工程学方面受过培训的个人 到生物学研究。另一个目标是训练细胞和分子生物学家将基因组- 在他们的研究中进行定量分析，使他们能够在这个跨学科的领域进行有效的合作。 接口.由于学员的教育背景和职业目标各不相同， 该计划强调高度个性化的培训计划和跨学科的研究。一 51名教师组成的多学科小组，选择他们参与基因组分析和他们强大的 协作互动的记录，包括培训团队。研究经验得到补充 有各种教学课程和选修课。学员们还参加了有关道德操守的讨论。 研究行为和基因组研究的伦理、法律的和社会影响。的知识广度 和程序的凝聚力是通过学员参与两个系列研讨会， 研究和计算生物学、期刊俱乐部和研究报告。在未来五年，我们会 继续扩大我们在基因组学，蛋白质组学，仪器开发，计算 生物学和统计基因组学。我们要求资金，以培养12名博士前和4名博士后研究员， 年受训人员将具备在学术和生物医学领域取得成功所需的技能。 基因组学的进步使21世纪的研究环境成为可能。

项目成果

Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.

• DOI: 10.1016/j.celrep.2014.06.007
• 发表时间: 2014-07-10
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Hung CM;Calejman CM;Sanchez-Gurmaches J;Li H;Clish CB;Hettmer S;Wagers AJ;Guertin DA
• 通讯作者: Guertin DA

Convex clustering: an attractive alternative to hierarchical clustering.

凸聚类：层次聚类的有吸引力的替代品。

• DOI: 10.1371/journal.pcbi.1004228
• 发表时间: 2015-05
• 期刊: PLoS computational biology
• 影响因子: 4.3
• 作者: Chen GK;Chi EC;Ranola JM;Lange K
• 通讯作者: Lange K

Population stratification of a common APOBEC gene deletion polymorphism.

普通APOBEC基因缺失多态性的种群分层。

• DOI: 10.1371/journal.pgen.0030063
• 发表时间: 2007-04-20
• 期刊: PLOS GENETICS
• 影响因子: 4.5
• 作者: Kidd, Jeffrey M.;Newman, Tera L.;Tuzun, Eray;Kaul, Rajinder;Eichler, Evan E.
• 通讯作者: Eichler, Evan E.

A natural mutator allele shapes mutation spectrum variation in mice.

• DOI: 10.1038/s41586-022-04701-5
• 发表时间: 2022-05
• 期刊: Nature
• 影响因子: 64.8

Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes.

• DOI: 10.1242/dev.117010
• 发表时间: 2015-09-15
• 期刊: Development (Cambridge, England)
• 作者: Palpant NJ;Pabon L;Roberts M;Hadland B;Jones D;Jones C;Moon RT;Ruzzo WL;Bernstein I;Zheng Y;Murry CE
• 通讯作者: Murry CE