Development of FISH Molecular Diagnostics to support Clinical Trials at NCI

开发 FISH 分子诊断以支持 NCI 的临床试验

• 批准号: 10703114
• 负责人: Liqiang Xi
• 金额: $ 103.45万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10703114
• 关键词: American; Basic Science; Biological Assay; Biomedical Research; CCR; Chromosomal Duplication; Chromosomal translocation; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Collaborations; Communities; Development; Diagnostic; Diagnostic Services; Diagnostic tests; Eligibility Determination; Event; Fluorescent in Situ Hybridization; Formalin; Gene Rearrangement; Glioma; Goals; Gold; Hematologic Neoplasms; Institutes; Knowledge; Laboratories; Lung; Lymphoma; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of thorax; Modernization; Molecular; Oncogenes; Operative Surgical Procedures; Paraffin Embedding; Pathology; Patients; Pediatric Oncology; Pharmaceutical Preparations; Protocols documentation; Research; Research Personnel; Resources; Solid Neoplasm; Surgical Pathology; Testing; Therapeutic; Transplantation Immunology; United States National Institutes of Health; Urologic Oncology; Vaccines; base; bench to bedside; cancer genomics; cancer therapy; chemotherapy; clinical diagnostics; clinically significant; college; cost; design; detection test; improved; malignant breast neoplasm; molecular diagnostics; molecular pathology; neuro-oncology; novel diagnostics; personalized diagnostics; precision medicine; prognostic; research clinical testing; standard of care; targeted treatment

The FISH Lab in the Laboratory of Pathology is a valuable resource at CCR, NCI to support active NCI clinical protocols. The section provides clinical diagnostic service for CCR investigators with Fluorescence In Situ Hybridization (FISH) CLIA/CAP testing in support of Surgical Pathology diagnostics and testing patients for NCI clinical protocol eligibility. More importantly, the laboratory represents a bench-to-bedside bridge that keeps pace with the latest discoveries in biomedical research, bringing new discoveries to clinical patient testing more rapidly than would be available from reference laboratories. The FISH Lab currently supports 16 clinical trials at the NCI. That includes requests from the entire community of CCR investigators: Neuro-Oncology Branch, Thoracic & GI Malignancies Branch, Vaccine Branch, Pediatric Oncology Branch, Experimental Transplantation and Immunology Branch, Surgery Branch, Urologic Oncology Branch, Office of the Director. The active test menu includes FISH assays for clinically significant chromosomal translocations and amplification events in solid tumors and hematologic malignancies. The FISH Lab actively participates in research collaborations with other investigators within the CCR and other NIH Institutes to advance basic and clinical research.

病理学实验室的FISH实验室是CCR，NCI的宝贵资源， 支持活跃的NCI临床协议。该组提供临床诊断服务， CCR研究者使用荧光原位杂交（FISH）CLIA/CAP检测支持 外科病理学诊断和NCI临床方案合格性测试患者。 更重要的是，实验室代表了一个从实验室到床边的桥梁， 生物医学研究的最新发现，为临床患者带来新的发现 测试速度比参考实验室更快。FISH实验室 目前支持NCI的16项临床试验。其中包括来自整个 CCR研究者社区：神经肿瘤学分支，胸胃肠道肿瘤学分支， 疫苗分支，儿科肿瘤学分支，实验移植和免疫学分支， 外科分支，泌尿肿瘤分支，主任办公室。活动测试菜单 包括用于临床显著染色体易位和扩增的FISH检测 实体瘤和恶性血液病事件。FISH实验室积极参与 与CCR和其他NIH研究所内的其他研究人员进行研究合作， 推进基础和临床研究。