Development of FISH Molecular Diagnostics to support Clinical Trials at NCI

开发 FISH 分子诊断以支持 NCI 的临床试验

• 批准号: 10926690
• 负责人: Liqiang Xi
• 金额: $ 65.13万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10926690
• 关键词: American; Basic Science; Biological Assay; Biomedical Research; CCR; Certification; Chromosomal Duplication; Chromosomal translocation; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Collaborations; Communities; Development; Diagnostic; Diagnostic Services; Eligibility Determination; Event; Fluorescent in Situ Hybridization; Formalin; Gene Rearrangement; Glioma; Goals; Hematologic Neoplasms; Immunology; Knowledge; Laboratories; Lung; Lymphoma; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of thorax; Modernization; Molecular; Oncogenes; Operative Surgical Procedures; Paraffin Embedding; Pathology; Patients; Pediatric Oncology; Pharmaceutical Preparations; Protocols documentation; Research; Research Personnel; Resources; Solid Neoplasm; Surgical Pathology; Testing; Therapeutic; Transplantation; United States National Institutes of Health; Urologic Oncology; Vaccines; bench to bedside; cancer genomics; cancer therapy; chemotherapy; clinical diagnostics; clinically significant; college; cost; design; detection test; improved; malignant breast neoplasm; molecular diagnostics; molecular pathology; neuro-oncology; novel diagnostics; personalized diagnostics; precision medicine; prognostic; research clinical testing; standard of care; targeted treatment

The FISH Lab in the Laboratory of Pathology is a valuable resource at CCR, NCI to support active NCI clinical protocols. The section provides clinical diagnostic service for CCR investigators with Fluorescence In Situ Hybridization (FISH) CLIA/CAP testing in support of Surgical Pathology diagnostics and testing patients for NCI clinical protocol eligibility. More importantly, the laboratory represents a bench-to-bedside bridge that keeps pace with the latest discoveries in biomedical research, bringing new discoveries to clinical patient testing more rapidly than would be available from reference laboratories. The FISH Lab currently supports 16 clinical trials at the NCI. That includes requests from the entire community of CCR investigators: Neuro-Oncology Branch, Thoracic & GI Malignancies Branch, Vaccine Branch, Pediatric Oncology Branch, Experimental Transplantation and Immunology Branch, Surgery Branch, Urologic Oncology Branch, Office of the Director. The active test menu includes FISH assays for clinically significant chromosomal translocations and amplification events in solid tumors and hematologic malignancies. The FISH Lab actively participates in research collaborations with other investigators within the CCR and other NIH Institutes to advance basic and clinical research.

病理实验室的FISH实验室是NCI CCR的宝贵资源，可以支持NCI的临床方案。该部门通过荧光原位杂交（FISH） CLIA/CAP测试为CCR研究人员提供临床诊断服务，以支持外科病理学诊断和测试患者的NCI临床方案资格。更重要的是，该实验室代表了从实验室到病床的桥梁，与生物医学研究的最新发现保持同步，比参考实验室更快地将新发现带到临床患者测试中。FISH实验室目前在NCI支持16项临床试验。这包括来自整个CCR研究人员社区的请求：神经肿瘤科、胸部和胃肠道恶性肿瘤科、疫苗科、儿科肿瘤科、实验移植和免疫学科、外科科、泌尿外科肿瘤科、主任办公室。活性检测菜单包括FISH检测，用于实体瘤和血液恶性肿瘤中临床显著的染色体易位和扩增事件。FISH实验室积极参与与CCR和其他NIH研究所的其他研究人员的研究合作，以推进基础和临床研究。