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Identification of Calcium integrin binding protein 1 (CIB1) competitor

Identification of Calcium integrin binding protein 1 (CIB1) competitor
钙整合素结合蛋白 1 (CIB1) 竞争对手的鉴定
批准号：
10691120
负责人：
Anton Simeonov
金额：
$25.96万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10691120
关键词：
Antiplatelet DrugsBinding ProteinsBiological AssayBlood PlateletsCalciumCalcium BindingCollaborationsCollectionDataExhibitsGrowthImpairmentIntegrin BindingIntegrinsMediatingMusPharmaceutical PreparationsSignal TransductionTestingThrombusValidationfollow-uphigh throughput screeningminiaturizepreventsmall molecule

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中文摘要
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英文摘要
This collaboration seeks to uncover small molecules capable of preventing the association of CIB1 and IIb3 as potential anti-platelet agents. During this period, the collaborative team utilized the previously optimized and miniaturized CIB1 assay to conduct a quantitative high-throughput screen of several of NCGC's small molecule collections. Identified hits were cherrypicked for initial validation using the primary assay, and were subsequently tested in follow-up assays to provide additional activity data.
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