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Heart Rate Characteristics Monitoring in Newborn Infant

新生儿心率特征监测

基本信息

批准号：
7373497
负责人：
JOSEPH RANDALL MOORMAN
金额：
$ 31.81万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-03-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7373497
关键词：
Acceleration Acute Algorithms Antibiotics Area Catastrophic Illness Cessation of life Characteristics Clinical Clinical Data Clinical Research Complication Deceleration Derivation procedure Diagnostic Early Diagnosis Economics Entropy Glucose Goals Health Heart Rate Hospitalization Hour Incidence Infant Infection Knowledge Lead Length of Stay Measures Mechanical ventilation Medical Modeling Monitor National Institute of Child Health and Human Development Neonatal Neonatal Intensive Care Units Newborn Infant Patient Care Patients Performance Phase Range Rate Research Research Design Research Personnel Risk Screening procedure Sepsis Site Statistical Models Testing Update Validation Very Low Birth Weight Infant Vinblastine Work concept cytokine day improved mathematical model mortality neonate novel novel strategies predictive modeling programs social

项目摘要

DESCRIPTION (provided by applicant): Sepsis is a major health problem in high-risk newborn infants in the neonatal intensive care unit (NICU), where it occurs in 25 percent of very low birth weight infants and leads to a more than doubling of mortality and a 50 percent increase in hospital stay. Abnormal heart rate characteristics (HRC) of reduced variability and transient decelerations occur early in the course of neonatal sepsis, and predictive multivariable models for sepsis and death have been developed at one center and validated at another. Our long-term goal is to test the hypothesis that continuous HRC monitoring will improve care of these patients by earlier diagnosis of sepsis and other sub-acute, potentially catastrophic illnesses. We propose to advance toward this objective by completing three research aims. In Aim 1, we will test the hypothesis that incorporating conventional lab tests and clinical findings with HRC will lead to improved predictive models for early diagnosis of late-onset neonatal sepsis. In Aim 2, we will identify mechanism-specific tests and findings, and test the hypothesis that they add information in predictive models of late-onset neonatal sepsis. The clinical research design for these Aims is a derivation of multivariable predictive statistical models from one set of patients followed by a validation phase using clinical data from a second set of patients. In Aim 3, we will develop new mathematical measures that detect abnormal HRC early in the course of late-onset neonatal sepsis, in particular, measures of deceleration characteristics. We feel that HRC monitoring in the NICU is a truly novel approach, and we intend to lead the field in developing predictive algorithms for clinical use in the early diagnosis of neonatal sepsis.

描述（由申请人提供）：败血症是新生儿重症监护病房（NICU）高危新生儿的主要健康问题，在25%的极低出生体重婴儿中发生，导致死亡率增加一倍以上，住院时间增加50%。异常心率特征（HRC）变异性降低和短暂减速发生在新生儿脓毒症的早期过程中，脓毒症和死亡的预测多变量模型已经在一个中心开发，并在另一个中心验证。我们的长期目标是验证这样一个假设，即持续的HRC监测将通过早期诊断败血症和其他亚急性、潜在的灾难性疾病来改善对这些患者的护理。我们建议通过完成三个研究目标来推进这一目标。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The principles of whole-hospital predictive analytics monitoring for clinical medicine originated in the neonatal ICU.

DOI：
10.1038/s41746-022-00584-y
发表时间：
2022-03-31
期刊：
NPJ digital medicine
影响因子：
15.2
作者：
Randall Moorman J
通讯作者：
Randall Moorman J

Cardiovascular oscillations at the bedside: early diagnosis of neonatal sepsis using heart rate characteristics monitoring.

DOI：
10.1088/0967-3334/32/11/s08
发表时间：
2011-11
期刊：
Physiological measurement
影响因子：
3.2
作者：
Moorman JR;Delos JB;Flower AA;Cao H;Kovatchev BP;Richman JS;Lake DE
通讯作者：
Lake DE

Periodic heart rate decelerations in premature infants.

DOI：
10.1258/ebm.2010.009336
发表时间：
2010-04
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
0
作者：
Flower AA;Moorman JR;Lake DE;Delos JB
通讯作者：
Delos JB

Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care.

DOI：
10.1109/iembs.2011.6091407
发表时间：
2011
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
0
作者：
Moorman JR;Rusin CE;Lee H;Guin LE;Clark MT;Delos JB;Kattwinkel J;Lake DE
通讯作者：
Lake DE

Septicemia mortality reduction in neonates in a heart rate characteristics monitoring trial.

DOI：
10.1038/pr.2013.136
发表时间：
2013-11
期刊：
PEDIATRIC RESEARCH
影响因子：
3.6
作者：
Fairchild, Karen D.;Schelonka, Robert L.;Kaufman, David A.;Carlo, Waldemar A.;Kattwinkel, John;Porcelli, Peter J.;Navarrete, Cristina T.;Bancalari, Eduardo;Aschner, Judy L.;Walker, M. Whit;Perez, Jose A.;Palmer, Charles;Lake, Douglas E.;O'Shea, T. Michael;Moorman, J. Randall
通讯作者：
Moorman, J. Randall