Complexity: Innovations in Promoting Health through Team Science

项目摘要/摘要 复杂的慢性病(CCCS)在世界范围内导致大量的发病率和死亡率， 对弱势和低/中等收入地区的影响不成比例。尽管许多CCCS是可以预防的， 患者目前受益于疾病诊断和治疗的持续改进，与CCC相关 发病率和死亡率仍然很高。由于与相互关联的 影响健康结果的易感因素，多方面的方法对于确定未来至关重要 可以预防和管理CCCS的干预措施，并最大限度地减少/管理以下疾病的短期和长期后遗症 治疗和疾病本身。未来发现创新和有效的方法以最大限度地减少CCC 负担取决于新兴研究人员从事团队科学的技能和意愿，这提供了 与单一的纪律方法相比，更多的成功机会。此次T32竞争续订 应用程序将使护士科学家在以下情况下利用协作科学团队和网络 在高度复杂的背景下开发和测试改善健康的干预措施。此应用程序构建 通过拓展团队科学领域的培训机会，对复杂性这一重要概念进行了阐述。 因此，这份名为《复杂性：促进健康的创新》的T32续订申请的目标 通过团队科学(Cheetah)，是为了培养11名博士前实习生成为创新的科学家 将利用团队科学方法促进患有(或处于风险)的个人和人群的健康 CCCS。本提案中概述的教学计划、研究培训和指导计划如下 与我们目前成功的T32培训计划保持一致，但我们将扩大之前的三年培训 计划一个四年计划，以促进更多的团队科学培训。 具体地说，我们将培训护士科学家：1)调查复杂的个人、社会和 影响高危人群或确诊人群健康的环境因素 慢性病为干预措施的设计和测试提供信息；2)在以下情况下整合团队科学方法 开发和测试创新干预措施以解决高度复杂的问题；3)设计和测试 促进健康的创新方法，防止个人患上慢性病 和高危人群水平；4)设计和测试促进健康的创新方法 在那些患有慢性病的人中，使他们能够很好地生活在慢性病中。 培训计划由四大支柱组成：课程工作、研究经验、指导和 职业社会化，包罗万象，包括带领和参与团队。学员将受益于 个性化的发展计划和跨学科的指导团队。促进团队科学是一项交叉的 在国家卫生研究所(NIH)战略计划和国家护理研究所内削减主题 研究(NINR)优先促进跨学科研究，以推进症状科学。

Project Summary/Abstract Complex chronic conditions (CCCs) cause substantial morbidity and mortality worldwide and disproportionately affect disadvantaged and low/middle income regions. Although many CCCs are preventable, and patients currently benefit from ongoing improvements in disease diagnosis and treatment, CCC-associated morbidity and mortality remains substantial. Due to the inherent complexity associated with the inter-related predisposing factors that influence health outcomes, multi-faceted approaches are critical to identifying future interventions that can prevent and manage CCCs, and minimize/manage the short and long-term sequelae of treatment and the disease itself. Future discovery of innovative and impactful approaches to minimize CCC burden depends on the skill and willingness of emerging researchers to engage in team science, which offers enhanced opportunities for success compared to a single disciplinary approach. This T32 competitive renewal application will prepare nurse scientists to leverage collaborative science teams and networks when developing and testing interventions to improve health in the context of high complexity. This application builds on the important concept of complexity by expanding the training opportunities in the area of team science. Thus, the goal of this T32 renewal application, entitled Complexity: Innovations in Promoting Health through Team Science (CHEeTAh), is to educate 11 pre-doctoral trainees to become innovative scientists who will leverage team science approaches to promote health for individuals and populations with (or at risk for) CCCs. The pedagogic program, research training, and mentorship plans outlined in this proposal are consistent with our current successful T32 training program, but we will expand the previous three-year training plan to a four-year plan to facilitate more training in team science. Specifically, we will train nurse scientists to: 1) Investigate the complex array of personal, social, and environmental factors that influence the health of individuals and populations at risk for or diagnosed with chronic illness to inform the design and testing of interventions; 2) Integrate team science approaches when developing and testing innovative interventions to address highly complex problems; 3) Design and test innovative approaches to promote health which prevent the development of chronic conditions at the individual and population levels in those at higher risk; and 4) Design and test innovative approaches to promote health among those with chronic conditions to enable them to live well with chronic illness. The training program is organized in four pillars: course work, research experience, mentoring, and professional socialization, all inclusive of leading and participating in teams. Trainees will benefit from an individualized development plan and an interdisciplinary mentorship team. Promoting team science is a cross- cutting theme within the National Institute of Health (NIH) strategic plan and the National Institute of Nursing Research (NINR) priority to foster cross-disciplinary research to advance symptom science.