Detection of Lipid Infiltration in the Heart with MRI

描述（由申请人提供）：拟申请项目的目标是发展磁共振成像（MRI）方法来检测心脏中的脂质浸润。该项目的主要目的是改善心律失常性右心室发育不良（ARVD）的诊断，这是一种以右心室纤维脂肪浸润为特征的疾病，可导致心室功能障碍和死亡。所提出的方法是基于获得单独的心脏脂质和水的图像，然后可以单独或一起观察以可视化脂质浸润。初步结果表明，双反转快速自旋回波方法（DIRFSE）在检测心脏脂质浸润方面取得了显着改善，其中脂质和水k空间数据的采集是交错的。与临床上用于检测心脏脂质浸润的传统方法相比，交错DIR-FSE方法产生的图像具有更好的对比度-噪声比，并且由血流和运动引起的伪影更少。本资助的目的是进一步改进交错DIR-FSE方法，以及基于梯度和自旋回波采集的替代方法（DIR-GRASE），并与目前临床使用的方法进行比较。工作的具体目的是：(1)进一步改进DIR-FSE和DIR-GRASE方法。这将包括一系列技术发展和成像参数的优化，旨在实现最佳空间分辨率，脂质/水分离和噪声性能。(2)在1.5 t磁场的临床研究中对Aims 1中提出的方法进行评价。(3)对3.0 t磁场下的方法进行扩展和评价。我们工作的中心假设是，一种更好的心脏脂质检测方法可以显著提高ARVD和其他以脂质浸润为特征的病理的诊断。

DESCRIPTION (provided by applicant): The goal of the proposed project is to develop magnetic resonance imaging (MRI) methods for the detection of lipid infiltration in the heart. The main purpose of the project is to improve the diagnosis of a condition known as Arrhythmogenic Right Ventricular Dysplasia (ARVD) a disease characterized by fibrofatty infiltration in the right ventricle that leads to ventricular malfunction and death. The proposed methods are based on obtaining separate lipid and water images of the heart which can then be observed separately or together to visualize lipid infiltration. Preliminary results have shown that significant improvements in the detection of lipid infiltration in the heart are obtained with a double-inversion fast spin-echo method (DIRFSE) where the acquisition of lipid and water k-space data is interleaved. Compared to conventional methods used in the clinic for the detection of lipid infiltration in the heart the interleaved DIR-FSE method yields images with better contrast-to-noise ratio and less artifacts caused by flow and motion. The purpose of this grant is to further improve the interleaved DIR-FSE method, and an alternative method based on the acquisition of gradient and spin-echoes (DIR-GRASE), and to evaluate their performance against the methods currently used in the clinic. The specific aims of the work are: (1) To further improve the DIR-FSE and DIR-GRASE methods. This will include a series of technical developments and optimization of imaging parameters aiming at optimal spatial resolution, lipid/water separation, and noise performance. (2) To evaluate the methods proposed in Aims 1 in a clinical study at a magnetic field of 1.5 T. (3) To extend and evaluate methods at a magnetic field of 3.0 T. The central hypothesis of our work is that a better methodology to detect lipid in the heart can significantly improve the diagnosis of ARVD and other pathologies that are characterized by lipid infiltration.