DETECTION OF ARTERIAL WALL DISORDERS BY MRI

描述 申请人的长期职业目标是成为一名独立的 磁共振成像(MRI)领域的研究员，她在那里 希望集中精力提高诊断能力 对技术的认识和对MRI之间关系的认识 参数和人体病理生理学(重点是心血管 问题)。因此，提议的应用程序的目标是获得实践经验 开发磁共振成像在临床磁共振成像技术方面的体会 动脉结构变化的活体检测技术 与病理状态相关的壁，如动脉粥样硬化， 动脉瘤性扩张和高血压。该项目的重点是 检测动脉内膜下脂肪沉积的MRI方法及MRI研究进展 方法可以准确地检测到 人类的动脉壁。水的抑制，基于不同的 扩散性质、自旋-晶格弛豫时间和化学位移 脂和水之间的自旋，将用于对内膜下进行成像 脂类。这些技术将被用来为患有 动脉硬化。精确测量自旋-自旋弛豫的磁共振方法 (T2)、磁化转移程度和扩散将实施到 想象一下动脉壁的水成分。的扩散各向异性 动脉瘤患者的动脉壁将通过核磁共振测量 膨胀，以估计组织的程度 弹性蛋白/胶原蛋白基质。自旋-自旋弛豫时间的变化，程度 将测量高血压和高血压患者的磁化转移和弥散 血压正常的个体，与主动脉顺应性和严重度相关 疾病的威胁。用变化来解释MRI参数的变化 在高血压引起的动脉壁结构中，自发性 高血压大鼠(SHR)将作为高血压的动物模型。磁共振成像 测量将在自发性高血压和正常血压的动脉中进行。 并与体内动脉被动机械测量进行相关分析 以及动脉壁的组成。该项目将被实施。 由物理学家亚瑟·F·格米特罗教授赞助 拥有丰富的医学成像经验，史蒂文·戈德曼教授， 医学博士说，他是一位在临床研究方面拥有丰富经验的心脏病专家。多数 该项目将在临床核磁共振和生物核磁共振中进行 申请人将在那里工作的亚利桑那大学的设施 在有磁共振技术专家、心脏病专家、放射科医生和 生理学家。为研究获得必要的背景资料，并 培训部分项目，申请者将参加医学方面的课程 影像、电子学和生理学在拨款的头几年。

DESCRIPTION The applicant's long-term career goal is to become an independent investigator in the field of magnetic resonance imaging (MRI) where she would like to concentrate her efforts to improve the diagnostic capability of the technique and understanding of the relationship between MRI parameters and human pathophysiology (with emphasis in cardiovascular problems). Thus, the goal of the proposed application is to gain hands-on experience in the technical aspects of clinical MRI by developing MRI techniques for the in vivo detection of structural changes in the arterial wall associated with pathological states, such as atherosclerosis, aneurysmal dilation, and hypertension. The project focuses on the development of MRI methods to detect subintimal lipid deposits and MRI methods that can accurately detect changes in the water component of the arterial wall in humans. Water-suppression, based on the differences in diffusion properties, spin-lattice relaxation times, and chemical shift between lipid and water spins, will be implemented for imaging subintimal lipids. These techniques will be used to image patients with atherosclerosis. MRI methods to accurately measure spin-spin relaxation (T2), extent of magnetization transfer, and diffusion will be implemented to image the water component of the arterial wall. The diffusion anisotropy of the arterial wall will be measured by MRI in patients with aneurysmal dilation in order to estimate the degree of organization of the elastin/collagen matrix. Changes in spin-spin relaxation times, extent of magnetization transfer, and diffusion will be measured in hypertensive and normotensive individuals and correlated with aortic compliance and severity of disease. To interpret the changes in MRI parameters in terms of changes in the structure of the arterial wall due to hypertension, the spontaneous hypertensive rat (SHR) will be used as an animal model of hypertension. MRI measurements will be carried out in the arteries of SHR and normotensive rats and correlated with in vivo arterial passive mechanical measurements and with the composition of the arterial wall. The project will be carried out under the sponsorship of Professor Arthur F. Gmitro, Ph.D., a physicist with extensive experience in medical imaging, and Professor Steven Goldman, M.D., a cardiologist with extensive experience in clinical research. Most of the project will be carried out at the Clinical MRI and Biological NMR facilities at the University of Arizona where the applicant will be working in an environment with MR technologists, cardiologists, radiologists, and physiologists. To obtain the necessary background for the research and training parts of the project, the applicant will take courses in medical imaging, electronics, and physiology during the first years of the grant.