High performance SPECT System for Cardiac Imaging

用于心脏成像的高性能 SPECT 系统

• 批准号: 10064098
• 负责人: Hamid Sabet
• 金额: $ 77.71万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10064098
• 关键词: Area; Arizona; Biological Models; Body mass index; Caliber; Calibration; Cardiac; Cardiac Volume; Cause of Death; Clinical; Collimator; Computer software; Coronary Arteriosclerosis; Crystallization; DCNU; Development; Discipline of Nuclear Medicine; Electrocardiogram; Electronics; Elements; Evaluation; Floods; Gamma Cameras; Gamma Rays; Geometry; Goals; Grant; Head; Health Care Costs; Heart; Hospitals; Image; Lasers; Length; Lesion; Manufacturer Name; Maps; Measures; Mechanics; Medical center; Methods; Modeling; Morbidity - disease rate; Morphologic artifacts; Obesity; Optics; Organ; Patients; Pattern; Performance; Physicians' Offices; Physiologic pulse; Positioning Attribute; Positron-Emission Tomography; Price; Procedures; Process; Recovery; Reporting; Research Project Grants; Research Proposals; Resolution; Rest; Sampling; Scanning; Semiconductors; Side; Silicon; Source; System; Systems Integration; Techniques; Thallium Myocardial Perfusion Imaging Stress Test; Thick; Time; attenuation; base; cardiac single photon emission computed tomography; cost; cost effective; density; design; detector; diagnostic accuracy; digital; heart imaging; high resolution imaging; image reconstruction; imager; imaging modality; imaging study; improved; innovation; mortality; prototype; reconstruction; screening; sensor; single photon emission computed tomography; social; statistics; trend

Abstract Single Photon Emission Computed Tomography (SPECT) is still the mainstay for cardiac screening. Current state of the art cardiac SPECT systems (Spectrum-Dynamic's D-SPECT and GE's Discovery NM530) use CZT semiconductor detectors which results in a number of cost-performance tradeoffs. They are based on the use of large collimator holes (compared with collimators used in standard dual head gamma camera) to increase the system sensitivity that may result in poor image resolution when no resolution recovery applied. The main objective of this project is to develop a high-sensitivity and high-spatial resolution SPECT system for cardiac applications. To make such an organ-specific SPECT system widely available however, the development cost has to be practical so that the system acquisition by the medical centers, hospitals and even physician offices is not cost-prohibitive. It should be mentioned that the CZT-based systems are much more expensive than a standard dual head gamma-camera. In this grant we plan to improve the performance of Cardiac SPECT without increasing the development cost. In order to achieve our goals we envision a SPECT system build from 8-10 mm thick conventional scintillators (CsI:Tl or NaI:Tl) with one-sided readout using silicon multipliers (SiPM) arrays. Owing to their high density, availability, and price which is at least an order of magnitude smaller than CZT, CsI (or NaI) is an attractive scintillator to use for out project. Our goal is to achieve high spatial image resolution and 0.1% scanner sensitivity which is about 10-times larger than dual-head gamma camera. We will utilize laser-induced optical barriers (LIOB) technique to fabricate the scintillator arrays.

摘要