Novel laser-processed scintillation detector for high-resolution PET scanners

用于高分辨率 PET 扫描仪的新型激光加工闪烁探测器

基本信息

批准号：
9197984
负责人：
Hamid Sabet
金额：
$ 21.77万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-12-21 至 2018-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9197984
关键词：
Address Animal Model Animals Behavior Biochemical Process Biological Markers Collection Computer Simulation Crystallization Data Development Diamond Elements Gamma Rays Goals Image Imagery Knowledge Lasers Lateral Light Location Magnetic Resonance Imaging Measurement Mechanical Stress Mechanics Methods Modality Modeling Modernization Nature Optics Organism Output Pattern Performance Pharmacologic Substance Physics Physiological Processes Polishes Positron-Emission Tomography Price Process Property Refractive Indices Research Research Project Grants Research Proposals Resolution Shapes Side Structure Surface System Techniques Technology Thick Time Work base cost cost effective density design detector driving force human disease imaging study imaging system improved indexing molecular imaging novel pre-clinical process optimization public health relevance thermal stress

项目摘要

DESCRIPTION (provided by applicant): Small animal PET studies are crucial in development of new pharmaceuticals and therapies as well as quantification of diverse biochemical and physiological processes in living organism. Visualized and quantified imaging of structures in small animals, however, imposes stringent requirements on the imaging system. Satisfying these requirements simultaneously necessitates expensive approaches and typically results in trading off between key performance metrics such as spatial resolution and sensitivity. The scintillators used in the majority of the modern PET systems and those under development are high density orthosilicate-based materials such as LYSO, LSO, LGSO, and GSO thanks to their high stopping power, fast decay time, non- hygroscopic nature, and relatively high light output. These scintillators are mechanically pixelated to form an array of scintillator elements to achieve high spatial resolution. However, array fabrication with pixels that have small cross-section (e.g. 1x1 mm2) and large thickness (e.g. 15 mm) is challenging and expensive which leads to a number of issues such as light collection problem, practical difficulties of accurate and consistent crystal size, and high cost associated with fine crystal cutting and surface treatment (polishing). In the mechanically pixelated arrays, a reflecting material is inserted between the pixels which leads to low packing fraction and thereby loss of sensitivity to gamma rays. Our goal is develop a PET detector using recently emerged technology called Laser-Induced Optical barriers (LIOB) in that we create optical barriers within the scintillation detector to control the light spread function and hence the spatial resolution. The significance of this research work is that using LIOB, development of high sensitivity PET detectors with sub-millimeter intrinsic spatial and DOI capability is achievable in a very cost effective manner. Our specific aims are to 1) Simulate the properties of laser induced optical barriers and correlate the results with experimental data. 2) Model a laser processed detector and optimize the optical barriers pattern, and 3) Fabricate and characterize LYSO detectors processed by LIOB technique.

描述（由应用提供）：小型动物宠物研究对于新药和疗法的开发以及生物中潜水员生化和物理过程的量化至关重要。但是，对小动物中结构的可视化成像，但是，成像系统上不可能严格要求。满足这些要求只是必要的方法，通常会导致在空间分辨率和灵敏度等关键性能指标之间进行交易。在大多数现代宠物系统和正在开发的宠物系统中使用的闪光灯是高密度的矫正材料，例如Lyso，LSO，LGSO和GSO，感谢它们的高停止功率，快速的衰减时间，非Hygroscopic性质，相对较高的光输出。这些闪光灯被机械像素化以形成一系列闪烁体元素以实现高空间分辨率。但是，具有较小横截面的像素的阵列制造（例如 1x1 mm2）和较大的厚度（例如15毫米）具有挑战性且昂贵，这导致了许多问题，例如收集问题，准确且一致的晶体尺寸的实际困难以及与精细的晶体切割和表面处理（抛光）相关的高成本（抛光）。在机械像素化的阵列中，在像素之间插入反射材料，从而导致堆积分数低，从而丧失对伽马射线的敏感性。我们的目标是使用最近出现的称为激光诱导的光屏障（LIOB）的技术开发宠物探测器，因为我们在闪烁检测器中创建光屏障这项研究工作的意义在于，使用LIOB，以非常有效的方式可以实现具有亚毫米固有空间和DOI能力的高灵敏度宠物探测器。我们的具体目的是1）模拟激光诱导的光屏障的性质，并将结果与实验数据相关联。 2）模拟激光处理的检测器并优化了光屏障模式，3）制造和表征LIOB技术处理的LYSO探测器。