High performance SPECT System for Cardiac Imaging

用于心脏成像的高性能 SPECT 系统

• 批准号: 10527342
• 负责人: Hamid Sabet
• 金额: $ 65.8万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10527342
• 关键词: Area; Arizona; Biological Models; Body mass index; Calibration; Cardiac; Cardiac Volume; Cause of Death; Clinical; Collimator; Computer software; Coronary Arteriosclerosis; DCNU; Dedications; Development; Diameter; Discipline of Nuclear Medicine; Electrocardiogram; Electronics; Elements; Evaluation; Floods; Gamma Cameras; Gamma Rays; Geometry; Goals; Grant; Head; Health Care Costs; Heart; Hospitals; Image; Lasers; Length; Lesion; Magnetic Resonance Imaging; Manufacturer; Maps; Marketing; Measures; Mechanics; Medical center; Methods; Modeling; Morbidity - disease rate; Morphologic artifacts; Obesity; Optics; Organ; Patients; Pattern; Penetration; Performance; Physicians' Offices; Physiologic pulse; Positioning Attribute; Positron-Emission Tomography; Price; Procedures; Process; Recovery; Reporting; Research Project Grants; Research Proposals; Resolution; Rest; Rotation; Sampling; Scanning; Semiconductors; Silicon; Source; System; Systems Integration; Techniques; Thallium Myocardial Perfusion Imaging Stress Test; Thick; attenuation; cardiac single photon emission computed tomography; cost; cost effective; density; design; detector; diagnostic accuracy; digital; fabrication; heart imaging; high resolution imaging; image reconstruction; imager; imaging modality; imaging study; improved; innovation; mortality; prototype; reconstruction; screening; sensor; single photon emission computed tomography; social; statistics; trend

Abstract Single Photon Emission Computed Tomography (SPECT) is still the mainstay for cardiac screening. Current state of the art cardiac SPECT systems (Spectrum-Dynamic's D-SPECT and GE's Discovery NM530) use CZT semiconductor detectors which results in a number of cost-performance tradeoffs. They are based on the use of large collimator holes (compared with collimators used in standard dual head gamma camera) to increase the system sensitivity that may result in poor image resolution when no resolution recovery applied. The main objective of this project is to develop a high-sensitivity and high-spatial resolution SPECT system for cardiac applications. To make such an organ-specific SPECT system widely available however, the development cost has to be practical so that the system acquisition by the medical centers, hospitals and even physician offices is not cost-prohibitive. It should be mentioned that the CZT-based systems are much more expensive than a standard dual head gamma-camera. In this grant we plan to improve the performance of Cardiac SPECT without increasing the development cost. In order to achieve our goals we envision a SPECT system build from 8-10 mm thick conventional scintillators (CsI:Tl or NaI:Tl) with one-sided readout using silicon multipliers (SiPM) arrays. Owing to their high density, availability, and price which is at least an order of magnitude smaller than CZT, CsI (or NaI) is an attractive scintillator to use for out project. Our goal is to achieve high spatial image resolution and 0.1% scanner sensitivity which is about 10-times larger than dual-head gamma camera. We will utilize laser-induced optical barriers (LIOB) technique to fabricate the scintillator arrays.

抽象的 单光子发射计算机断层扫描（SPECT）仍然是心脏筛查的主要支柱。当前的 最先进的心脏Spect系统（Spectrum-Dynamic的D-Spect和GE的发现NM530）使用CZT 半导体探测器会导致许多成本绩效的权衡。他们基于使用 大型准直孔孔（与标准双头伽玛相机中使用的准直仪相比）以增加 当未应用分辨率恢复时，系统敏感性可能导致图像分辨率差。主 该项目的目的是为心脏开发高敏性和高空间分辨率SPECT系统 申请。为了使这样的器官特定的SPECT系统广泛可用，开发成本 必须是实用的，以便医疗中心，医院甚至医师办公室的系统收购是 不成本过敏。应该提到的是，基于CZT的系统比 标准双头伽玛相机。在这笔赠款中，我们计划在没有的情况下提高心脏SPECT的性能 增加开发成本。为了实现我们的目标，我们设想SPECT系统从8-10构建 毫米厚的常规闪烁体（CSI：TL或NAI：TL），使用硅乘数（SIPM）单方面读数（SIPM） 数组。由于它们的高密度，可用性和价格至少比 CZT，CSI（或NAI）是用于OUT项目的有吸引力的闪光灯。我们的目标是实现高空间形象 分辨率和0.1％的扫描仪灵敏度，比双头伽玛相机大约10倍。我们将 利用激光诱导的光屏障（LIOB）技术来制造闪烁体阵列。