High performance SPECT System for Cardiac Imaging

摘要 单光子发射计算机断层扫描（SPECT）仍然是心脏筛查的支柱。电流 最先进的心脏SPECT系统（Spectrum-Dynamic的D-SPECT和GE的Discovery NM 530）使用CZT 半导体探测器，这导致许多成本性能折衷。它们是基于使用 大的准直器孔（与标准双头伽马照相机中使用的准直器相比）以增加 系统灵敏度，当不应用分辨率恢复时，可能导致图像分辨率变差。主要 本课题的目的是研制一种高灵敏度、高空间分辨率的心脏SPECT系统， 应用.然而，为了使这种器官特异性SPECT系统广泛可用，开发成本 必须实用，以便医疗中心、医院甚至医生办公室的系统采购， 成本不高。应该提到的是，基于CZT的系统比传统系统昂贵得多。 标准双头伽玛相机在这项资助中，我们计划提高心脏SPECT的性能， 增加了开发成本。为了实现我们的目标，我们设想SPECT系统构建从8-10 mm厚的传统放大器（CsI：Tl或NaI：Tl），采用硅倍增器（SiPM）进行单侧读出 阵由于它们的高密度、可用性和价格， CZT、CsI（或NaI）是一种很有吸引力的闪烁体。我们的目标是实现高空间图像 分辨率和0.1%的扫描仪灵敏度，比双头伽马相机大约大10倍。我们将 利用激光诱导光垒（LIOB）技术制备闪烁体阵列。

Abstract Single Photon Emission Computed Tomography (SPECT) is still the mainstay for cardiac screening. Current state of the art cardiac SPECT systems (Spectrum-Dynamic's D-SPECT and GE's Discovery NM530) use CZT semiconductor detectors which results in a number of cost-performance tradeoffs. They are based on the use of large collimator holes (compared with collimators used in standard dual head gamma camera) to increase the system sensitivity that may result in poor image resolution when no resolution recovery applied. The main objective of this project is to develop a high-sensitivity and high-spatial resolution SPECT system for cardiac applications. To make such an organ-specific SPECT system widely available however, the development cost has to be practical so that the system acquisition by the medical centers, hospitals and even physician offices is not cost-prohibitive. It should be mentioned that the CZT-based systems are much more expensive than a standard dual head gamma-camera. In this grant we plan to improve the performance of Cardiac SPECT without increasing the development cost. In order to achieve our goals we envision a SPECT system build from 8-10 mm thick conventional scintillators (CsI:Tl or NaI:Tl) with one-sided readout using silicon multipliers (SiPM) arrays. Owing to their high density, availability, and price which is at least an order of magnitude smaller than CZT, CsI (or NaI) is an attractive scintillator to use for out project. Our goal is to achieve high spatial image resolution and 0.1% scanner sensitivity which is about 10-times larger than dual-head gamma camera. We will utilize laser-induced optical barriers (LIOB) technique to fabricate the scintillator arrays.