High performance SPECT System for Cardiac Imaging

用于心脏成像的高性能 SPECT 系统

• 批准号: 10312007
• 负责人: Hamid Sabet
• 金额: $ 79.26万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10312007
• 关键词: Area; Arizona; Biological Models; Body mass index; Caliber; Calibration; Cardiac; Cardiac Volume; Cause of Death; Clinical; Collimator; Computer software; Coronary Arteriosclerosis; Crystallization; DCNU; Development; Discipline of Nuclear Medicine; Electrocardiogram; Electronics; Elements; Evaluation; Floods; Gamma Cameras; Gamma Rays; Geometry; Goals; Grant; Head; Health Care Costs; Heart; Hospitals; Image; Lasers; Length; Lesion; Magnetic Resonance Imaging; Manufacturer Name; Maps; Measures; Mechanics; Medical center; Methods; Modeling; Morbidity - disease rate; Morphologic artifacts; National Center for Advancing Translational Sciences; Obesity; Optics; Organ; Patients; Pattern; Performance; Physicians' Offices; Physiologic pulse; Positioning Attribute; Positron-Emission Tomography; Price; Procedures; Process; Recovery; Reporting; Research Project Grants; Research Proposals; Resolution; Rest; Sampling; Scanning; Semiconductors; Side; Silicon; Source; System; Systems Integration; Techniques; Thallium Myocardial Perfusion Imaging Stress Test; Thick; Time; attenuation; base; cardiac single photon emission computed tomography; cost; cost effective; density; design; detector; diagnostic accuracy; digital; heart imaging; high resolution imaging; image reconstruction; imager; imaging modality; imaging study; improved; innovation; mortality; prototype; reconstruction; screening; sensor; single photon emission computed tomography; social; statistics; trend

Abstract Single Photon Emission Computed Tomography (SPECT) is still the mainstay for cardiac screening. Current state of the art cardiac SPECT systems (Spectrum-Dynamic's D-SPECT and GE's Discovery NM530) use CZT semiconductor detectors which results in a number of cost-performance tradeoffs. They are based on the use of large collimator holes (compared with collimators used in standard dual head gamma camera) to increase the system sensitivity that may result in poor image resolution when no resolution recovery applied. The main objective of this project is to develop a high-sensitivity and high-spatial resolution SPECT system for cardiac applications. To make such an organ-specific SPECT system widely available however, the development cost has to be practical so that the system acquisition by the medical centers, hospitals and even physician offices is not cost-prohibitive. It should be mentioned that the CZT-based systems are much more expensive than a standard dual head gamma-camera. In this grant we plan to improve the performance of Cardiac SPECT without increasing the development cost. In order to achieve our goals we envision a SPECT system build from 8-10 mm thick conventional scintillators (CsI:Tl or NaI:Tl) with one-sided readout using silicon multipliers (SiPM) arrays. Owing to their high density, availability, and price which is at least an order of magnitude smaller than CZT, CsI (or NaI) is an attractive scintillator to use for out project. Our goal is to achieve high spatial image resolution and 0.1% scanner sensitivity which is about 10-times larger than dual-head gamma camera. We will utilize laser-induced optical barriers (LIOB) technique to fabricate the scintillator arrays.

抽象的 单光子发射计算机断层扫描 (SPECT) 仍然是心脏筛查的支柱。当前的 最先进的心脏 SPECT 系统（Spectrum-Dynamic 的 D-SPECT 和 GE 的 Discovery NM530）使用 CZT 半导体探测器，这导致了许多成本性能权衡。它们基于使用 大准直器孔（与标准双头伽玛相机中使用的准直器相比）以增加 当未应用分辨率恢复时，系统灵敏度可能会导致图像分辨率较差。主要 该项目的目标是开发一种高灵敏度、高空间分辨率的心脏 SPECT 系统 应用程序。然而，为了广泛使用这种器官特异性 SPECT 系统，开发成本 必须实用，以便医疗中心、医院甚至医生办公室购买系统 成本不高。应该提到的是，基于 CZT 的系统比基于 CZT 的系统贵得多。 标准双头伽玛相机。在这笔赠款中，我们计划提高心脏 SPECT 的性能，而无需 增加开发成本。为了实现我们的目标，我们设想构建 8-10 个 SPECT 系统 毫米厚的传统闪烁体（CsI:Tl 或 NaI:Tl），使用硅倍增器 (SiPM) 进行单侧读出 数组。由于它们的高密度、可用性和价格至少比 CZT、CsI（或 NaI）是一种有吸引力的闪烁体，可用于我们的项目。我们的目标是实现高空间图像 分辨率和0.1%扫描仪灵敏度，比双头伽玛相机高约10倍。我们将 利用激光诱导光学屏障（LIOB）技术来制造闪烁体阵列。