Managing Excess Infant Energy Intake by Increasing Satiation Responsiveness in Dyadic Feeding Interactions

通过增加二元喂养互动中的饱足反应来管理婴儿能量摄入过多

• 批准号: 10721119
• 负责人: Amanda K Crandall
• 金额: $ 13.23万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10721119
• 关键词: Address; Age; Award; Behavior; Behavioral; Behavioral Mechanisms; Child; Chronic Disease; Code; Consumption; Cues; Desire for food; Development; Distress; Eating; Eating Behavior; Effectiveness; Energy Intake; Environment; Equation; Equity; Feeding behaviors; Feeling; Food; Frequencies; Growth; Health; Hour; Hunger; Infant; Intake; Intervention; Investigation; Knowledge; Longevity; Longitudinal cohort study; Measures; Mentors; Milk; Modeling; Mothers; Nature; Parents; Pathway interactions; Pattern; Personal Satisfaction; Phase; Physiological; Physiology; Prevention; Prevention approach; Psychology; Public Health; Reporting; Research; Risk; Sampling; Satiation; Scientist; Signal Transduction; Sucking Behavior; Techniques; Testing; Training; United States; Video Recording; Weight Gain; aged; behavior change; cohort; comparative; dyadic interaction; excessive weight gain; experience; experimental study; feeding; hedonic; improved; infancy; milk intake; multidisciplinary; nutrition; obesity in children; obesity prevention; pleasure; pressure; prevent; programs; response; sucking; therapy design

PROJECT SUMMARY Emerging evidence suggests that infants with greater appetitive drive may benefit from different feeding approaches for the prevention of obesity and chronic disease. Slower milk delivery may be a promising strategy, given that slower eating is associated with reduced intake and lesser weight gain throughout the lifespan, including in infancy. In a sample of 243 infants aged 2-4 months, slower milk delivery increased sucking effort and reduced intake. The results of this experiment, though reflective of only a single pair of feedings, suggest that slower milk delivery may be a promising intervention strategy for addressing excessive infant weight gain. However, many questions remain before the development of such an intervention could be pursued, including the mechanism for this behavior change. The proposed project will examine infant, mother, and dyadic interaction behavior during the feedings with slower milk delivery from this experiment, and compare infant, mother, and dyadic behavior between faster and slower milk delivery to address the following aims. Aim 1 (K99): To examine the relative contributions of infant (satiation signaling, behavioral distress, sucking vigor), maternal (responsivity, behavioral distress), and dyadic (mutuality, feeding duration) behaviors as mechanisms explaining the effect of slowed milk delivery on reduced intake in a single feeding. Aim 2 (K99): To examine whether the pathways of association in this conceptual model differ between infants with typical versus high appetitive drive. Aim 3 (R00): Among 220 infants at age 8-12 weeks, to examine—across 72 hours of feedings in which milk delivery rate is slowed by 30% compared to typical—the cross-lagged associations of changes from baseline in sucking vigor and feeding frequency with infant satiation signaling, infant behavioral distress, and dyadic mutuality and to determine if these associations differ based on higher versus lower infant appetitive drive. The PI, Dr. Crandall, is a behavioral scientist with an interdisciplinary background in nutrition, psychology, and public health. Her growing research program seeks to understand the cascading effect of high infant appetitive drive, integrating the dyadic nature of infant eating/feeding with the hope of developing safe, effective, and equitable intervention strategies. With the support of a multidisciplinary team of mentors, during the training phase of this award Dr. Crandall will grow her content knowledge of the physiology of infant eating behavior and growth; gain experience with three levels of behavioral coding of mother-infant feeding interactions; gain experience with structural equation modeling techniques; and, in the R00 phase, conduct an independent investigation of infant/mother feeding behavior with slower milk delivery across multiple days. At the conclusion of the award period, Dr. Crandall will be poised to test an intervention designed to manage high appetitive drive and excessive intake, among infants most at risk, while promoting maternal and infant well-being and the health of the dyadic interaction.

项目摘要 新兴证据表明，食欲更大的婴儿可能会受益于不同的喂养 预防肥胖和慢性疾病的方法。牛奶输送速度较慢可能是一个承诺 策略，鉴于饮食速度较慢与摄入量减少有关，并且在整个过程中体重增加较低 寿命，包括婴儿期。在243名2-4个月的婴儿的样本中，牛奶输送速度较慢 吮吸努力和减少摄入量。该实验的结果，尽管仅反映了一对 喂食，表明牛奶输送速度较慢可能是解决超出问题的承诺干预策略 婴儿体重增加。但是，在开发这种干预之前仍存在许多问题 追求，包括这种行为改变的机制。拟议的项目将检查婴儿，母亲， 在喂养过程中，该实验的牛奶输送较慢，并且 比较婴儿，母亲和二元行为更快和慢牛奶的递送以解决以下 目标。 AIM 1（K99）：检查婴儿的相对贡献（饱腹信号传导，行为困扰， 吮吸活力），孕产妇（响应性，行为困扰）和二元（相互性，进食持续时间）行为 作为解释牛奶递送对单个喂养减少摄入量减少摄入量的作用。目标2 （K99）：检查这种概念模型中关联的途径是否不同 典型与高食用驱动器。目标3（r00）：在8-12周的220名婴儿中，检查 与典型的牛奶输送率相比，牛奶输送率减慢了30％的72小时喂食（交叉滞后） 从基线吮吸活力和喂养频率与婴儿饱食信号传导的变化的关联， 婴儿的行为困扰和二元相互性，并确定这些关联是否基于较高 与较低的婴儿食欲。 PI Crandall博士是一位行为科学家，具有跨学科 营养，心理学和公共卫生背景。她不断发展的研究计划试图了解 高婴儿食欲的级联效应，将婴儿饮食/喂养的二元性质整合在一起 制定安全，有效和公平干预策略的希望。在一个支持 多学科导师团队，在该奖项的培训阶段，Crandall博士将增加她的内容 了解婴儿饮食行为和成长的生理学；获得三个级别的经验 母亲喂养相互作用的行为编码；通过结构方程建模获得经验 技术；并且，在R00阶段，对婴儿/母亲喂养行为进行独立投资 多天的牛奶输送速度较慢。在颁奖期结束时，Crandall博士将是 在婴儿中毒害用于测试旨在管理高胃口驱动和多余摄入量的干预措施。 大多数人都处于危险之中，同时促进了物物和婴儿的健康以及二元相互作用的健康状况。