Towards Curative Therapies for Hypogonadotropic Diseases

项目摘要 Kisspeptin、神经激肽B和强啡肽信号传导为GnRH神经元提供必要的指导和刺激。 虽然过去十年我们对这个信号网络的理解取得了非凡的进步， Grant采用新的测定法和体内受体激动剂和拮抗剂给药来挑战几种 生殖内分泌学的教条这些互补的方法，在恒河猴身上进行， 健康志愿者和生殖疾病患者，联合两名具有遗传学经验的研究人员， 生理学和药理学。这种跨学科的合作能够很好地解决 调节GnRH分泌的下丘脑结构。因此，通过在猴子和猴子之间流畅地翻译， 和人之间，青少年和成年人之间，生理学和病理生理学之间，这项赠款的目的是产生 性成熟的新见解，并为生殖障碍患者开发新的治疗方法。

PROJECT ABSTRACT Kisspeptin, neurokinin B, and dynorphin signaling provide essential guidance and stimulation to GnRH neurons. Though the past decade has seen extraordinary advances in our understanding of this signaling network, this grant employs novel assays and receptor agonist and antagonist administration in vivo to challenge several dogmas in reproductive endocrinology. These complementary approaches, performed in rhesus monkeys, healthy volunteers, and patients with reproductive disease, unite two investigators with experience in genetics, physiology, and pharmacology. This interdisciplinary collaboration is well positioned to attack the complexities of the hypothalamic architecture that regulates GnRH secretion. Thus, by translating fluidly between monkey and man, between juvenile and adult, and between physiology and pathophysiology, this grant aims to generate novel insights into sexual maturation and develop new treatments for patients with reproductive disorders.