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The role of the receptor complex and the cofactors in IGSF10 signaling

The role of the receptor complex and the cofactors in IGSF10 signaling
受体复合物和辅助因子在 IGSF10 信号传导中的作用
批准号:
10728450
负责人:
YUZURU SHIIO
金额:
$35.46万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-06-07 至 2028-05-31

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项目成果

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中文摘要
翻译
免疫球蛋白超家族成员10 (IGSF10)是一个大的分泌蛋白,涉及多种生物
英文摘要
Immunoglobulin superfamily member 10 (IGSF10) is a large, secreted protein implicated in multiple biological and pathological processes: IGSF10 mutations are associated with hereditary delayed puberty. Low IGSF10 expression is linked to more aggressive lung and breast cancers. A frameshift mutation in IGSF10 was found in a case of a hereditary skeletal disorder, Cleidocranial Dysplasia. IGSF10 A1672T variant was found in combined pituitary hormone deficiency. However, the mechanism of action of IGSF10 is unknown. The applicant’s group identified the cell surface receptor for IGSF10 and the downstream signaling pathway regulated by IGSF10. They also identified a putative co-receptor and a secreted co-factor for IGSF10. This project is directed towards understanding the roles of the receptor complex and the cofactors in IGSF10 signaling. The successful completion of the project will uncover the molecular mechanisms and the biological roles of the novel signaling pathway mediated by IGSF10. The knowledge gained from this project will lay the foundation for understanding the physiological roles of this novel signaling pathway as well as the pathological conditions associated with the dysregulation of this pathway.
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  • 批准号:
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  • 项目类别:
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  • 资助金额:
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  • 项目类别:
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  • 资助金额:
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  • 负责人:
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  • 项目类别:
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  • 资助金额:
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  • 批准年份:
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  • 负责人:
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