The role of the receptor complex and the cofactors in IGSF10 signaling

受体复合物和辅助因子在 IGSF10 信号传导中的作用

• 批准号: 10728450
• 负责人: YUZURU SHIIO
• 金额: $ 35.46万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-07 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10728450
• 关键词: Basic Science; Binding; Biological; Biological Process; Biology; C-terminal; Cell Line; Cell Proliferation; Cell Surface Proteins; Cell Surface Receptors; Cell model; Cells; Cleidocranial Dysplasia; Collaborations; Complex; Cysteine-Rich Domain; Delayed Puberty; Ewings sarcoma; Foundations; Frameshift Mutation; Future; Gene Expression; Glioma; Gonadotropin Hormone Releasing Hormone; Growth; Human; Immunoglobulins; Inherited; Knowledge; Leucine-Rich Repeat; Ligands; Link; Malignant neoplasm of lung; Mediating; Microglia; Molecular; Mus; Mutation; N-terminal; National Institute of Neurological Disorders and Stroke; Neurons; Pathologic; Pathologic Processes; Pathway interactions; Phenocopy; Physiological; Pituitary Hormones; Play; Protein Secretion; Protein Tyrosine Kinase; Proteomics; RET inhibition; Research; Role; Signal Pathway; Signal Transduction; Structure; System; Testing; Therapeutic; Tissues; United States National Institutes of Health; Variant; cofactor; hormone deficiency; immunoglobulin receptor; inhibitor; kinase inhibitor; knock-down; malignant breast neoplasm; member; migration; mutant; novel; olfactomedin; prevent; protein function; proto-oncogene protein c-ret; receptor; skeletal disorder; transcriptome sequencing; tumor

Immunoglobulin superfamily member 10 (IGSF10) is a large, secreted protein implicated in multiple biological and pathological processes: IGSF10 mutations are associated with hereditary delayed puberty. Low IGSF10 expression is linked to more aggressive lung and breast cancers. A frameshift mutation in IGSF10 was found in a case of a hereditary skeletal disorder, Cleidocranial Dysplasia. IGSF10 A1672T variant was found in combined pituitary hormone deficiency. However, the mechanism of action of IGSF10 is unknown. The applicant’s group identified the cell surface receptor for IGSF10 and the downstream signaling pathway regulated by IGSF10. They also identified a putative co-receptor and a secreted co-factor for IGSF10. This project is directed towards understanding the roles of the receptor complex and the cofactors in IGSF10 signaling. The successful completion of the project will uncover the molecular mechanisms and the biological roles of the novel signaling pathway mediated by IGSF10. The knowledge gained from this project will lay the foundation for understanding the physiological roles of this novel signaling pathway as well as the pathological conditions associated with the dysregulation of this pathway.

免疫球蛋白超家族成员10（IGSF10）是一种大的分泌蛋白，涉及多种生物学特性。 和病理过程：IGSF10突变与遗传性青春期延迟有关。低IGSF10 表达与更具侵袭性的肺癌和乳腺癌有关。IGSF 10基因的移码突变在1999年发现， 一个遗传性骨骼疾病的病例，锁骨颅骨发育不良。IGSF10 A1672T变异体在联合 垂体激素缺乏症然而，IGSF10的作用机制尚不清楚。 申请人的小组鉴定了IGSF 10的细胞表面受体和下游信号通路 由IGSF10监管。他们还确定了IGSF10的一个假定的辅助受体和一个分泌的辅助因子。这 该项目旨在了解IGSF 10中受体复合物和辅因子的作用 信号该项目的成功完成将揭示分子机制和生物学机制。 IGSF10介导的新型信号通路的作用。从这个项目中获得的知识将奠定 为理解这种新的信号通路的生理作用以及病理作用奠定了基础。 与该途径的失调相关的病症。