Columbia Center for Interdisciplinary Research on Alzheimer's Disease Disparities (CIRAD)

总体汇总 这是一项更新老年痴呆症相关资源中心的建议，用于少数民族老龄化研究（AD-RCMAR） 哥伦比亚大学阿尔茨海默病差异跨学科研究中心 （CIRAD）。CIRAD的主题重点是生物，行为，社会文化和环境 ADRD不平等的机制，包括风险和弹性因素，生物标志物，和生物标志物。至关重要 确定结构和社会系统暴露与ADRD结果之间的途径，以便设计 采取干预措施，缩小差距，减轻认知障碍和痴呆症的人口负担。超过 在过去的4.5年里，CIRAD已经建立了一个广泛的网络，包括核心领导人，科学家，导师， 来自哥伦比亚大学欧文医学中心、哥伦比亚大学 阿尔茨海默病研究中心（ADRC），哥伦比亚巴特勒老龄化中心，CTSA社区 参与核心，和纽约州立精神病研究所。我们聘请了来自世界各地的科学家和导师， 纽约市的机构，如纽约城市大学和纽约州立大学， 纽约大学、威尔康奈尔医学中心、蒙蒂菲奥里医学中心和阿尔伯特爱因斯坦医学院，以及 和全国其他机构一样。CIRAD核心领导团队包括前RCMAR科学家 他们以社区参与ADRD不平等研究而闻名。CIRAD的目标是提供 持续的指导和职业发展，对试点研究的支持，健康差异方面的培训，以及 与CIRAD科学家进行跨学科合作，并支持和加速机制研究 这样就可以缩小或消除这些差距。我们将通过以下方式实现我们的目标：目标1。到 建立和支持领导和行政核心，目标2。建立研究性教育的核心 这将支持一个项目，该项目将吸引和支持来自历史上被排除在外的早期调查人员， 对ADRD研究的独立职业感兴趣的背景，目标3。提供分析指导， 通过分析核心和目标4提供支持。加快ADRD差异机制的研究。

OVERALL SUMMARY This is a proposal to renew an Alzheimer's- related Resource Centers for Minority Aging Research (AD-RCMAR) called the Columbia University Center for Interdisciplinary Research on Alzheimer's Disease Disparities (CIRAD). The thematic focus of the CIRAD is biological, behavioral, sociocultural, and environmental mechanisms of ADRD inequalities, including risk and resilience factors, biomarkers, and caregiving. It is critical to identify pathways between structural and social systems of exposure and ADRD outcomes in order to design interventions to narrow disparities and reduce the population burden of cognitive impairment and dementia. Over the past 4.5 years, CIRAD has built an extensive network that includes Core Leaders, Scientists, mentors, and collaborators from the four schools of the Columbia University Irving Medical Center, the Columbia University Alzheimer's Disease Research Center (ADRC), the Columbia Butler Aging Center, the CTSA Community Engagement Core, and the New York State Psychiatric Institute. We have engaged Scientists and mentors from New York City based institutions such as the City University of New York and the State University of New York, NYU, Weill Cornell Medical Center, Montefiore Medical Center and Albert Einstein College of Medicine, as well as other institutions around the country. The CIRAD Core leadership team includes former RCMAR Scientists who are well known for community-engaged research on ADRD inequalities. The goal of CIRAD is to provide sustained mentoring and career development, support for pilot studies, training in health disparities, and interdisciplinary collaboration to CIRAD Scientists and to support and accelerate research on the mechanisms of ADRD disparities so that they can be narrowed or eliminated. We will achieve our goals through: Aim 1. To establish and support a Leadership and Administrative Core, Aim 2. To establish a Research Education Core that will support a program that engages and supports early-stage investigators from historically excluded backgrounds interested in an independent career in ADRD research, Aim 3. To provide analytic guidance and support via an Analysis Core, and Aim 4. To accelerate research on mechanisms of ADRD disparities.