Columbia Center for Interdisciplinary Research on Alzheimer's Disease Disparities (CIRAD)

总体总结 这是一项更新阿尔茨海默氏症相关少数族裔老龄化研究资源中心(AD-RCMAR)的提案 被称为哥伦比亚大学阿尔茨海默病差异跨学科研究中心 (CIRAD)。CIRAD的主题重点是生物、行为、社会文化和环境 ADRD不平等的机制，包括风险和复原力因素、生物标记物和照料。这是至关重要的 确定暴露的结构和社会系统与ADRD结果之间的路径，以便设计 旨在缩小差距和减轻认知障碍和痴呆症人口负担的干预措施。完毕 在过去的4.5年里，CIRAD建立了一个广泛的网络，其中包括核心领导者、科学家、导师和 来自哥伦比亚大学欧文医学中心、哥伦比亚大学四所学院的合作者 阿尔茨海默病研究中心(ADRC)、哥伦比亚管家老龄化中心、CTSA社区 Engagement Core和纽约州精神病研究所。我们聘请了来自 设在纽约市的机构，如纽约城市大学和纽约州立大学， 纽约大学、威尔·康奈尔医学中心、蒙特菲奥里医学中心和阿尔伯特·爱因斯坦医学院 和全国各地的其他机构一样。CIRAD核心领导团队包括前RCMAR科学家 他们以对ADRD不平等的社区参与研究而闻名。CIRAD的目标是提供 持续的辅导和职业发展，支持试点研究，培训健康差距，以及 与CIRAD科学家进行跨学科合作，支持和加快对机制的研究 消除ADRD差距，以便缩小或消除这些差距。我们将通过以下方式实现我们的目标：目标1. 建立和支持领导和管理核心，目标2.建立研究教育核心 这将支持一个项目，该项目将吸引和支持历史上被排除在外的早期调查人员 对独立从事ADRD研究感兴趣的背景，目标3。提供分析指导和 通过分析核心提供支持，目标4.加快对ADRD差异机制的研究。

OVERALL SUMMARY This is a proposal to renew an Alzheimer's- related Resource Centers for Minority Aging Research (AD-RCMAR) called the Columbia University Center for Interdisciplinary Research on Alzheimer's Disease Disparities (CIRAD). The thematic focus of the CIRAD is biological, behavioral, sociocultural, and environmental mechanisms of ADRD inequalities, including risk and resilience factors, biomarkers, and caregiving. It is critical to identify pathways between structural and social systems of exposure and ADRD outcomes in order to design interventions to narrow disparities and reduce the population burden of cognitive impairment and dementia. Over the past 4.5 years, CIRAD has built an extensive network that includes Core Leaders, Scientists, mentors, and collaborators from the four schools of the Columbia University Irving Medical Center, the Columbia University Alzheimer's Disease Research Center (ADRC), the Columbia Butler Aging Center, the CTSA Community Engagement Core, and the New York State Psychiatric Institute. We have engaged Scientists and mentors from New York City based institutions such as the City University of New York and the State University of New York, NYU, Weill Cornell Medical Center, Montefiore Medical Center and Albert Einstein College of Medicine, as well as other institutions around the country. The CIRAD Core leadership team includes former RCMAR Scientists who are well known for community-engaged research on ADRD inequalities. The goal of CIRAD is to provide sustained mentoring and career development, support for pilot studies, training in health disparities, and interdisciplinary collaboration to CIRAD Scientists and to support and accelerate research on the mechanisms of ADRD disparities so that they can be narrowed or eliminated. We will achieve our goals through: Aim 1. To establish and support a Leadership and Administrative Core, Aim 2. To establish a Research Education Core that will support a program that engages and supports early-stage investigators from historically excluded backgrounds interested in an independent career in ADRD research, Aim 3. To provide analytic guidance and support via an Analysis Core, and Aim 4. To accelerate research on mechanisms of ADRD disparities.