Columbia Center for Interdisciplinary Research on Alzheimer's Disease Disparities (CIRAD)

哥伦比亚阿尔茨海默病差异跨学科研究中心 (CIRAD)

• 批准号: 10730136
• 负责人: ADAM M BRICKMAN
• 金额: $ 65.41万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730136
• 关键词: Acceleration; Accountability; African American; African American population; Aging; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; American Indians; Awareness; Behavioral; Behavioral Research; Bioinformatics; Biological; Biological Markers; Cities; Clinical Trials; Collaborations; Communication; Communities; Country; Dementia; Dental; Direct Costs; Discipline of Nursing; Disparity; Educational workshop; Ensure; Environmental Risk Factor; Equity; Evaluation; Exclusion; Family; Funding; Goals; Grant; Health; Impaired cognition; Incidence; Inequality; Institution; Interdisciplinary Study; International; Internships; Latino; Latinx; Leadership; Life Cycle Stages; Longitudinal, observational study; Measures; Medical center; Medicine; Mental Health; Mentors; Mentorship; Methods; Minority; Minority-Serving Institution; New York; New York City; Not Hispanic or Latino; Outcome; Pathway interactions; Physicians; Pilot Projects; Policies; Population; Prevalence; Production; Psychometrics; Public Health; Quality of life; Regulation; Research; Research Institute; Research Personnel; Research Training; Resources; Risk Factors; Schools; Scientist; Sexism; Social Work; Stress; Surgeon; System; Training; Translations; Universities; Vascular Dementia; aging brain; career; career development; caregiving; college; community engaged research; community engagement; dementia caregiving; design; disease disparity; education research; frailty; health disparity; implementation science; innovation; interdisciplinary collaboration; interest; minority investigator; novel; programs; racism; resilience factor; skills; social; social culture; social disparities; social health determinants; sociocultural determinant; therapy design

OVERALL SUMMARY This is a proposal to renew an Alzheimer's- related Resource Centers for Minority Aging Research (AD-RCMAR) called the Columbia University Center for Interdisciplinary Research on Alzheimer's Disease Disparities (CIRAD). The thematic focus of the CIRAD is biological, behavioral, sociocultural, and environmental mechanisms of ADRD inequalities, including risk and resilience factors, biomarkers, and caregiving. It is critical to identify pathways between structural and social systems of exposure and ADRD outcomes in order to design interventions to narrow disparities and reduce the population burden of cognitive impairment and dementia. Over the past 4.5 years, CIRAD has built an extensive network that includes Core Leaders, Scientists, mentors, and collaborators from the four schools of the Columbia University Irving Medical Center, the Columbia University Alzheimer's Disease Research Center (ADRC), the Columbia Butler Aging Center, the CTSA Community Engagement Core, and the New York State Psychiatric Institute. We have engaged Scientists and mentors from New York City based institutions such as the City University of New York and the State University of New York, NYU, Weill Cornell Medical Center, Montefiore Medical Center and Albert Einstein College of Medicine, as well as other institutions around the country. The CIRAD Core leadership team includes former RCMAR Scientists who are well known for community-engaged research on ADRD inequalities. The goal of CIRAD is to provide sustained mentoring and career development, support for pilot studies, training in health disparities, and interdisciplinary collaboration to CIRAD Scientists and to support and accelerate research on the mechanisms of ADRD disparities so that they can be narrowed or eliminated. We will achieve our goals through: Aim 1. To establish and support a Leadership and Administrative Core, Aim 2. To establish a Research Education Core that will support a program that engages and supports early-stage investigators from historically excluded backgrounds interested in an independent career in ADRD research, Aim 3. To provide analytic guidance and support via an Analysis Core, and Aim 4. To accelerate research on mechanisms of ADRD disparities.

总结 这是续签阿尔茨海默氏症相关资源中心（AD-RCMAR）的一项建议（AD-RCMAR） 称哥伦比亚大学跨学科研究中心关于阿尔茨海默氏病差异 （Cirad）。 Cirad的主题重点是生物学，行为，社会文化和环境 ADRD不平等的机制，包括风险和弹性因素，生物标志物和护理。这很关键 确定曝光与社会系统之间的途径和aDRD结果，以设计 干预趋势狭窄，减轻了认知障碍和痴呆症的人口负担。超过 在过去的4。5年中，Cirad建立了一个广泛的网络，其中包括核心领导者，科学家，导师和 哥伦比亚大学欧文大学四所学校的合作者，哥伦比亚大学 阿尔茨海默氏病研究中心（ADRC），哥伦比亚巴特勒老化中心，CTSA社区 订婚核心和纽约州精神病学院。我们聘请了科学家和导师 纽约市的机构，例如纽约市和纽约州立大学， 纽约大学，威尔·康奈尔医学中心，蒙特菲奥尔医学中心和阿尔伯特·爱因斯坦医学院 作为全国其他机构。 CIRAD核心领导团队包括前RCMAR科学家 他们以社区参与ADRD不平等的研究而闻名。 Cirad的目标是提供 持续的指导和职业发展，对试点研究的支持，健康差异培训以及 与CIRAD科学家的跨学科合作，并支持和加速有关机制的研究 ADRD差异的差异，以便可以缩小或消除它们。我们将通过：目标1实现我们的目标。 建立并支持领导和行政核心，目标2。建立研究教育核心 这将支持一项参与并支持早期调查人员的计划 对ADRD研究独立职业感兴趣的背景，目的3。提供分析指导和 通过分析核心支持，目标4。加速对ADRD差异机制的研究。

项目成果

Psychometric Properties of a Spanish-Language Version of a Short-Form FAMCARE: Applications to Caregivers of Patients With Alzheimer's Disease and Related Dementias.

简短版 FAMCARE 西班牙语版本的心理测量特性：对阿尔茨海默病和相关痴呆症患者护理人员的应用。

• DOI: 10.1177/1074840719867345
• 发表时间: 2019
• 期刊: Journal of family nursing
• 影响因子: 3.1
• 作者: Teresi,JeanneA;Ocepek-Welikson,Katja;Ramirez,Mildred;Ornstein,KatherineA;Bakken,Suzanne;Siu,Albert;Luchsinger,JoséA
• 通讯作者: Luchsinger,JoséA

Plasma Amyloid and in vivo Brain Amyloid in Late Middle-Aged Hispanics.

• DOI: 10.3233/jad-210391
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Rippon, Brady;Palta, Priya;Tahmi, Mouna;Sherwood, Greysi;Soto, Luisa;Cespedes, Sandino;Mesen, Yanette;He, Hengda;Laing, Krystal;Moreno, Herman;Teresi, Jeanne;Razlighi, Qolamreza;Brickman, Adam M.;Zetterberg, Henrik;Luchsinger, Jose A.
• 通讯作者: Luchsinger, Jose A.

The Identity Vitality-Pathology model: A novel theoretical framework proposing "identity state" as a modulator of the pathways from structural to health inequity.

身份活力-病理学模型：一种新颖的理论框架，提出“身份状态”作为从结构性不平等到健康不平等路径的调节器。

• DOI: 10.1016/j.socscimed.2022.115495
• 发表时间: 2022-12
• 期刊: SOCIAL SCIENCE & MEDICINE
• 影响因子: 5.4
• 作者: Bey, Ganga S.

Application of Machine Learning Techniques to Examine Social Service Needs Among Hispanic Family Caregivers of Persons with Dementia.

• DOI: 10.3233/shti220776
• 发表时间: 2022-06-29
• 期刊: Studies in health technology and informatics
• 作者: Yoon, Sunmoo;Mendes, Alexandra;Burgio, Louis;Mittelman, Mary;Dunner, Ilana;Levine, Jed A;Hoyos, Carolina;Tipiani, Dante;Ramirez, Mildred;Teresi, Jeanne A;Luchsinger, Jose A
• 通讯作者: Luchsinger, Jose A

The use of subjective cognitive complaints for detecting mild cognitive impairment in older adults across cultural and linguistic groups: A comparison of the Cognitive Function Instrument to the Montreal Cognitive Assessment.

使用主观认知抱怨来检测跨文化和语言群体的老年人的轻度认知障碍：认知功能仪器与蒙特利尔认知评估的比较。

• DOI: 10.1002/alz.12804
• 发表时间: 2023
• 期刊: Alzheimer's & dementia : the journal of the Alzheimer's Association
• 作者: Li,Clara;Hong,Yue;Yang,Xiao;Zeng,Xiaoyi;Ocepek-Welikson,Katja;Eimicke,JosephP;Kong,Jian;Sano,Mary;Zhu,Carolyn;Neugroschl,Judith;Aloysi,Amy;Cai,Dongming;Martin,Jane;Loizos,Maria;Sewell,Margaret;Akrivos,Jimmy;Evans,Kirsten