Data Center for Acute to Chronic Pain Biosignatures

急性至慢性疼痛生物特征数据中心

• 批准号: 10789239
• 负责人: Martin Lindquist
• 金额: $ 7.91万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10789239
• 关键词: Acute; Administrative Supplement; Biological Markers; Collaborations; Data; Epidemic; Funding; Inflammatory; Institution; United States National Institutes of Health; Universities; biosignature; career; chronic pain; data centers; data integration; data resource; neural; opioid use; pain chronification; predictive marker; programs; psychosocial

Project Summary Understanding the mechanisms underlying the transition to chronic pain is key to mitigating the dual epidemics of chronic pain and opioid use in the U.S. As part of the NIH funded Acute to Chronic Pain Signatures (A2CPS) Program, we will leverage the data collected at the Data Integration and Resource Center (DIRC) at Johns Hopkins University and collaborating institutions. In this administrative supplement, we seek funding for an additional two-year period to develop the career of Dr. Michael Sun toward the aim of developing neural and inflammatory biomarkers and understand how such biomarkers predict and respond to opioid-use, as well as their psychosocial context.

项目摘要 了解向慢性疼痛转变的潜在机制是减轻双重流行病的关键 作为NIH资助的急性至慢性疼痛特征（A2CPS）的一部分， 计划，我们将利用约翰斯数据集成和资源中心（DIRC）收集的数据 霍普金斯大学及合作机构。在这份行政补充文件中，我们寻求资金， 额外的两年时间来发展Michael Sun博士的职业生涯，以发展神经和 炎症生物标志物，并了解这些生物标志物如何预测和响应阿片类药物的使用，以及 他们的社会心理背景