Data Center for Acute to Chronic Pain Biosignatures

了解向慢性疼痛转变的机制是关键 缓解美国慢性疼痛和阿片类药物使用的双重流行 RFA-RM-18-031，并作为 NIH 急性至慢性疼痛共同基金的一部分 签名（A2CPS）计划，我们将建立数据集成和资源中心 (DIRC) 整合成像、生理学、组学、行为和临床数据来开发 向慢性疼痛过渡的生物特征。该中心将设在 约翰霍普金斯大学生物统计系是众多合作者的纽带 (1) 高级数据科学和机器学习、(2) 神经影像学、(3) 方面的专业知识 基因组学和相关组学，(4) 可穿戴计算和基于智能手机的行为 评估，(5) 系统级预测生物特征，(6) 软件工程和 高性能计算，以及 (7) 来自 JHU 和的世界知名疼痛研究人员 其他机构。 JHU 生物统计学在同类院系中排名第一 国家，其独特的师资组合提供了灵活和 根据需要容纳不同数据类型的分析，以及独特的能力 通过在线课程和其他论坛进行科学宣传。提供计算 A2CPS 的基础设施和基于云的计算，我们与德克萨斯州合作 高级计算中心 (TACC)，在大规模计算方面拥有长期记录 合作并已经构建了许多我们认为理想的云计算工具 对于这个项目。该中心将由三个部分和一个行政核心组成。 行政核心将领导该中心并促进各中心之间的互动 该中心和整个 A2CPS 联盟的组成部分。数据协调 组件（DCC）将提供存储和处理、分析的基础设施 用于数据上传/查询/导出的管道、云计算和门户，以及其他 技术交付成果。数据集成和分析组件（DIAC）将 为管道和分析所收集的数据提供特定于数据类型的内容 A2CPS 联盟。科学外展组件 (SOC) 将使用 DCC- 开发门户基础设施来维护联盟内联网并进行外展 通过公共 A2CPS 门户。它还将组织各种现场和在线培训 和外展计划，包括创建免费的在线课程来传播 有关慢性疼痛和 A2CPS 工具、数据和模型的信息。

Understanding the mechanisms underlying the transition to chronic pain is a key to mitigating the dual epidemics of chronic pain and opioid use in the U.S. In response to RFA-RM-18-031, and as part of the NIH Common Fund Acute to Chronic Pain Signatures (A2CPS) Program, we will establish a Data Integration and Resource Center (DIRC) to integrate imaging, physiology, -omics, behavioral, and clinical data to develop biosignatures for the transition to chronic pain. The Center will be based in the Department of Biostatistics at JHU, a nexus for a wide range of collaborators with expertise in (1) advanced data science and machine learning, (2) neuroimaging, (3) genomics and related -omics, (4) wearable computing and smartphone-based behavioral assessment, (5) systems-level predictive biosignatures, (6) software engineering and high-performance computing, and (7) world-renowned pain researchers from JHU and other institutions. JHU Biostatistics is the top-ranked department of its kind in the country, and its unique blend of faculty provides the ability to be nimble and accommodate analysis of diverse data types as needed, and a unique capacity for scientific outreach through online courses and other forums. To deliver computing infrastructure and cloud-based computing for A2CPS, we partner with the Texas Advanced Computing Center (TACC), who have a long track record of large-scale collaborations and have already built many of the cloud computing tools we see as ideal for this project. The Center will consist of three components and an Administrative Core. The Administrative Core will lead the Center and facilitate interaction among the components of the Center and across the A2CPS consortium. The Data Coordination Component (DCC) will provide the infrastructure for storage and processing, analysis pipelines, cloud computing, and portals for data upload/query/export, in addition to other technical deliverables. The Data Integration and Analysis Component (DIAC) will provide data type-specific content for pipelines and analyses of data collected by the A2CPS consortium. The Scientific Outreach Component (SOC) will use DCC- developed portal infrastructure to maintain the consortium intranet and perform outreach via the public A2CPS portal. It will also organize a variety of in-person and online training and outreach programs, including the creation of free, online courses disseminating information about chronic pain and A2CPS tools, data, and models.