Administrative Core

响应RFA-RM-18-031，我们将建立一个从急性到慢性的数据中心 约翰·霍普金斯大学(JHU)的“疼痛生物签名”。该中心将作为 共同基金从急性到慢性的数据整合和资源中心 疼痛信号(A2CPS)计划。该中心将由三个组成部分和一个 管理核心(AC)。调查委员会将由首席调查员马丁领导。 Lindquist和Tor Wager在一个由 中心各组成部分和外部顾问的领导力 具有领导大型多站点项目的丰富经验。审计委员会将负责监督 并管理中心的组成部分，包括财务管理；人事 管理；安排和组织会议；维持资源。 咨询委员会还将负责促进 该中心的组成部分以及与多站点临床协调中心的合作 临床中心、Omics数据生成中心和NIH工作人员。它将：(1)减少 通过提供管理来跨越A2CPS财团的管理障碍 资源；(2)促进向更广泛的科学界介绍联盟的成果 社区；(3)作为组织经常性A2CPS联盟的中心枢纽 会议，包括面对面和虚拟会议；(4)定期提供 关于登记、患者评估、数据存储、数据质量、 以及向NIH和A2CPS其他成员发送的数据使用统计数据 财团；和(5)保持对必要基础设施的访问，以完成 中心的具体目标，包括研究、合作和传播。 总体而言，AC将促进一个激励的智力环境，以编织研究人员 参与A2CPS活动成为一个强大的跨学科社区。

In response to RFA-RM-18-031, we will establish a “Data Center for Acute to Chronic Pain Biosignatures” at Johns Hopkins University (JHU). The Center will serve as the Data Integration and Resource Center (DIRC) for the Common Fund Acute to Chronic Pain Signatures (A2CPS) Program. The Center will consist of three components and an Administrative Core (AC). The AC will be led by the Principal Investigators, Martin Lindquist and Tor Wager, with support from a steering committee consisting of the leadership of the various components of the Center and external consultants with significant experience with leading large-scale multisite projects. The AC will oversee and manage the Center components, including fiscal management; personnel management; scheduling and organization of meetings; and maintenance of resources. The AC will also be responsible for facilitating communication and interaction between the components of the Center, as well as with the Clinical Coordinating Center, Multisite Clinical Centers, Omics Data Generating Centers, and NIH staff. It will: (1) reduce administrative barriers across the A2CPS consortium by providing management resources; (2) facilitate presentation of consortium results to the broader scientific community; (3) serve as a central hub for organizing recurring A2CPS consortium meetings, including both face-to-face and virtual meetings; (4) provide regular quantitative updates on enrollment, patient assessments, data deposition, data quality, and data usage statistics, both to the NIH and to other members of the A2CPS consortium; and (5) maintain access to the necessary infrastructure for accomplishing the specific aims of Center, including research, collaboration, and dissemination. Overall, the AC will promote a stimulating intellectual environment to knit researchers involved in A2CPS activities into a strong interdisciplinary community.