Administrative Core

为响应RFA-RM-18-031，我们将建立一个“急性至慢性数据中心 疼痛生物特征”在约翰霍普金斯大学（JHU）。该中心将作为 数据集成和资源中心（DIRC）为共同基金急性到慢性 疼痛特征（A2 CPS）程序。该中心将由三个部分组成， 行政核心（AC）。AC将由首席研究员Martin Lindquist和Tor Wager在指导委员会的支持下， 中心各组成部分的领导和外部顾问， 领导大型多站点项目的丰富经验。AC会监督 并管理中心的组成部分，包括财务管理;人事 管理;会议的时间安排和组织;以及资源的维护。 AC还将负责促进以下人员之间的沟通和互动： 该中心的组成部分，以及与临床协调中心，多站点 临床中心、组学数据生成中心和NIH工作人员。它将：（1）减少 通过提供管理，跨越A2 CPS联盟的行政障碍 （2）促进向更广泛的科学界介绍联合会的成果; 社区;（3）作为组织经常性A2 CPS联盟的中心枢纽 会议，包括面对面会议和虚拟会议;（4）定期提供 关于入组、患者评估、数据存储、数据质量的定量更新， 和数据使用统计，无论是对NIH和其他成员的A2 CPS （5）保持必要的基础设施，以实现 中心的具体目标，包括研究，合作和传播。 总的来说，AC将促进一个刺激的智力环境， 参与A2 CPS活动成为一个强大的跨学科社区。

In response to RFA-RM-18-031, we will establish a “Data Center for Acute to Chronic Pain Biosignatures” at Johns Hopkins University (JHU). The Center will serve as the Data Integration and Resource Center (DIRC) for the Common Fund Acute to Chronic Pain Signatures (A2CPS) Program. The Center will consist of three components and an Administrative Core (AC). The AC will be led by the Principal Investigators, Martin Lindquist and Tor Wager, with support from a steering committee consisting of the leadership of the various components of the Center and external consultants with significant experience with leading large-scale multisite projects. The AC will oversee and manage the Center components, including fiscal management; personnel management; scheduling and organization of meetings; and maintenance of resources. The AC will also be responsible for facilitating communication and interaction between the components of the Center, as well as with the Clinical Coordinating Center, Multisite Clinical Centers, Omics Data Generating Centers, and NIH staff. It will: (1) reduce administrative barriers across the A2CPS consortium by providing management resources; (2) facilitate presentation of consortium results to the broader scientific community; (3) serve as a central hub for organizing recurring A2CPS consortium meetings, including both face-to-face and virtual meetings; (4) provide regular quantitative updates on enrollment, patient assessments, data deposition, data quality, and data usage statistics, both to the NIH and to other members of the A2CPS consortium; and (5) maintain access to the necessary infrastructure for accomplishing the specific aims of Center, including research, collaboration, and dissemination. Overall, the AC will promote a stimulating intellectual environment to knit researchers involved in A2CPS activities into a strong interdisciplinary community.