BSL3 management and practice of infectious disease research at HTRL

HTRL 传染病研究的 BSL3 管理和实践

• 批准号: 10793948
• 负责人: JOSEPH A. KANABROCKI
• 金额: $ 246.91万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793948
• 关键词: 2019-nCoV; Accidents; Air; Animal Model; Antibiotic Therapy; Antibiotics; Articulation; Awareness; Bacteria; Bacterial Infections; Biological; Biological Assay; Biomedical Research; Bioterrorism; Birds; COVID-19; COVID-19 pandemic; Certification; Chicago; Classification; Clostridium difficile; Collaborations; Communicable Diseases; Communities; Containment; Coronavirus; Country; Decontamination; Dedications; Dengue; Development; Disease; Doctor of Philosophy; Ebola virus; Economics; Emergency Situation; Emerging Communicable Diseases; Engineering; Environment; Environmental Health; Epidemic; Equilibrium; Evaluation; Event; Financial Support; Fostering; Frequencies; Funding Opportunities; Genome; Goals; Health; Human; Human Resources; Immune response; Immunity; In Vitro; Infection; Infectious Agent; Infectious Diseases Research; Influenza; Institution; Investigation; Knowledge; Laboratories; Laboratory Personnel; Leadership; Livestock; Maintenance; Mammals; Measures; Medical; Microbe; Microbiology; Middle East Respiratory Syndrome Coronavirus; Modeling; Molecular; Morbidity - disease rate; Mutation; National Institute of Allergy and Infectious Disease; Operations Research; Panic; Pathogenicity; Persons; Pharmaceutical Preparations; Population; Preventive; Procedures; Protective Devices; Protocols documentation; Public Health; RNA Viruses; Regulation; Research; Research Activity; Research Support; Resources; Risk; Role; SARS coronavirus; Safety; Scientist; Secure; Services; Societies; Structure; System; Technology; Testing; Therapeutic Intervention; Toxin; Training; Training Activity; Training and Education; Training and Infrastructure; Universities; Vaccines; Variant; Viral; Virulence; Virus; ZIKA; Zoonoses; biodefense; biosafety level 3 facility; biosecurity; chikungunya; combat; companion animal; cost; drug resistant pathogen; hazard; human disease; improved; in vivo; insight; medical countermeasure; meetings; methicillin resistant Staphylococcus aureus; microbial; operation; pathogen; pathogenic microbe; prevent; preventive intervention; professor; public health emergency; repaired; response; transmission process; viral outbreak; virtual; web portal

PROJECT ABSTRACT (OVERALL) Our nation’s ability to detect, prevent and counter bioterrorism and emerging infectious diseases depends on technologies that are generated through biomedical research on disease-causing microbes and understanding human immune responses to infection. Following bioterrorism events in 2001, the National Institute of Allergy and Infectious Diseases established the Regional Biocontainment Laboratory (RBL) Network, to promote safe research in 12 Biosafety Level 3 (BSL3) laboratories. In turn, Institutions and Universities hosting these RBLs sustained the management of these facilities, fostered a strong Biosafety culture, and fueled research inquiries into the molecular mechanisms whereby microbes cause human disease. The University of Chicago hosts the Regional Biocontainment Howard Taylor Ricketts Laboratory (HTRL) operated by its Department of Microbiology since 2009. When this nation began to implement shutdowns to prevent the spread of COVID-19, essential professionals at the HTRL continued key management operations and pivoted their expertise to study SARS-CoV2. This momentum would not have been possible without the existing expertise and dedication of engineers, biosafety officers, veterinary staff, scientists, as well as financial support from the University. The goal of this proposal is to present a plan to maintain the safe operation and management of the BSL3 space of the Regional Biocontainment HTRL and to continue training professionals who will provide research support services for the development of measures necessary to mitigate and protect the public's health from infectious diseases that may be the result of intentional, accidental, or naturally occurring health emergency. This plan will be implemented by three cores. Core 1 Facility Management, Maintenance and Operations (C1Facilities@HTRL) led by George Langan, describes activities that support continuous BSL3 containment through decontamination, retesting, certification, preventive maintenance, repair or replacement of building systems and compliance with Biosecurity, Environmental Health, and Biosafety regulations. Core 2 BSL3 Practices (C2BSL3Practice@HTRL) led by Joseph Kanabrocki, describes activities for the training of personnel and the development of Standard Operating Procedures as well as activities to sustain a safe and secure environment. Core 3 Biocontainment Research Support Services (C3ResearchSupport@HTRL) led by Dominique Missiakas, describes research capabilities for the study of Risk Group 3 and Select Agent pathogens. HTRL will use a web-based portal to advertise and offer research services such as isolation and characterization of pathogens, virulence and countermeasure studies using in vitro and in vivo assays and animal models. Monthly virtual and annual in-person meetings between RBL Directors will identify opportunities for collaborations, improvements, and cross-training. These interactions will expand the capacity of the RBL network as a whole to respond to public health emergencies, conduct evaluations of threats and countermeasures, and provide education and training to conform with biosafety standards.

项目摘要（总体）