Practices Core

实践核心

• 批准号: 10793944
• 负责人: William Paul Duprex
• 金额: $ 72.71万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793944
• 关键词: Acceleration; Accountability; Administrator; Animals; Biological; Biology; Bioterrorism; Certification; Complex; Creativeness; Discipline; Elements; Emergency Situation; Emerging Communicable Diseases; Engineering; Ensure; Environmental Health; Equipment and supply inventories; Event; Evolution; Goals; Human Resources; In Vitro; Industry; Infection; Infrastructure; International; Intervention; Laboratories; Laboratory Animals; Laboratory Assistant; Lead; Mentors; Mission; Monitor; National Institute of Allergy and Infectious Disease; Outcome; Pathogenesis; Procedures; Reference Standards; Regulation; Reporting; Reproducibility; Research; Research Personnel; Rest; Running; Safety; Scientist; Secure; Services; Side; Standardization; Supervision; System; Toxin; Training; Tube; Universities; Vaccine Research; Veterinarians; Viral; Vision; Work; animal resource; biodefense; biosafety level 3 facility; biosecurity; cohort; data integrity; data quality; data quality/integrity; emerging pathogen; equipment training; hands on instruction; in vivo; medical countermeasure; member; novel; operation; pandemic disease; pandemic preparedness; pathogen; preclinical development; programs; quality assurance; research facility; response; transmission process

PRACTICES CORE ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. Biocontainment work is operationally complex, infrastructure-dense, and comprehensively regulated. Running BSL-3 laboratories safely, securely and successfully demands having a well-organized and highly integrated team of administrators, scientists, biosafety/biosecurity professionals, engineers/facilities staff and veterinarians/zootechnical staff. This is especially important in multi-pathogen, multi-user research facilities that study standard and select agent BSL-3 pathogens. The Practices Core will support all the basic functions of the RBL enabling scientific programs to be rigorously managed and ensuring overall data integrity for reproducible outcomes. It will provide the requisite theoretical and practical trainings to onboard new RBL Investigators and their teams who wish to work in BSL-3 and ABSL-3 biocontainment. It will provide biosafety and biosecurity support and guarantee the facility meets all current compliance regulations for Tier 1 select agent registered laboratories. Provision of technical and support for the RBL in Pittsburgh will ensure we are ready to respond to any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.

实践核心 摘要： 该大学疫苗研究中心（CVR）内的区域生物防护实验室（RBL） 匹兹堡大学是生物安全3级（BSL-3）感染生物学中心。RBL的使命有三个方面， 致力于病原体的出现、进化和宿主间传播，研究 新出现的传染病，并加快新的干预措施和医疗 预防大流行和生物防御的对策。我们的愿景是成为一个全球公认的，高度- 协作，创造性和前瞻性的感染生物学家团队谁是准备应对新出现的 在国家和国际一级的生物威胁。整个设施都已在 选择代理和毒素（DSAT）。它汇集了来自不同学科的感染生物学家和临床医生 他们需要BSL-3和动物（A）BSL-3设施进行广泛的病毒和细菌研究计划。 生物防护工作操作复杂，基础设施密集，监管全面。运行 BSL-3实验室的安全，可靠和成功的要求有一个组织良好，高度集成 管理人员、科学家、生物安全/生物安保专业人员、工程师/设施工作人员和 兽医/动物技术人员。这在多病原体、多用户研究设施中尤其重要， 研究BSL-3病原体标准和筛选。实践核心将支持 RBL使科学计划得到严格管理，并确保整体数据的完整性， 结果。它将为新的RBL调查员提供必要的理论和实践培训， 他们的团队谁希望在BSL-3和ABSL-3生物遏制工作。它将提供生物安全和生物安保 支持并保证设施符合所有当前的1级精选注册代理的合规性法规 laboratories.为匹兹堡的RBL提供技术和支持将确保我们准备好应对 在发生另一次大流行时对一系列新出现的传染病作出的任何国家反应，或 生物恐怖袭击支持这一群BSL-3科学家，他们可以在一个新的领域转向新病原体的研究。 紧急情况下，肯定会支付股息。