Integrated Services Core

综合服务核心

• 批准号: 10793945
• 负责人: William Paul Duprex
• 金额: $ 115.86万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793945
• 关键词: Acceleration; Administrator; Aerosols; Alphavirus; Animal Model; Animals; Avian Influenza A Virus; Biological; Biology; Bioluminescence; Bioterrorism; Cells; Cellular biology; Clinical; Complex; Confocal Microscopy; Coronavirus; Creativeness; Data; Dimensions; Discipline; Disease model; Emergency Situation; Emerging Communicable Diseases; Engineering; Ensure; Equipment; Event; Evolution; Felis catus; Ferrets; Fluorescence; Hamsters; Immune response; Immunoassay; Immunology procedure; In Vitro; Infection; Infrastructure; International; Intervention; Investments; Laboratories; Laboratory Personnel; Laboratory Research; Laboratory Technicians; Mission; Modeling; Monitor; Mus; Orthobunyavirus; Orthomyxoviridae; Oryctolagus cuniculus; PET/CT scan; Pathogenesis; Pathogenicity; Rattus; Recombinants; Reporter Genes; Reporting; Research; Research Infrastructure; Research Personnel; Rest; Rodent; Running; Scientist; Secure; Services; Side; System; Testing; Therapeutic; Therapeutic Intervention; Tissues; Toxin; Training; Universities; Vaccine Research; Veterinarians; Viral; Vision; Work; arm; biodefense; bioimaging; biosafety level 3 facility; biosecurity; cohort; digital; emerging pathogen; experience; imaging capabilities; in vivo; in vivo imaging; medical countermeasure; multimodality; nonhuman primate; novel; operation; pandemic disease; pandemic preparedness; pathogen; preclinical development; programs; prophylactic; quality assurance; research facility; response; reverse genetics; single cell sequencing; single molecule; single photon emission computed tomography; transmission process; whole body imaging

INTEGRATED SERVICES CORE ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. Biocontainment work is operationally complex, infrastructure-dense, and comprehensively regulated. Running BSL-3 laboratories safely, securely and successfully demands having a well-organized and highly integrated team of administrators, scientists, biosafety/biosecurity professionals, engineers/facilities staff and veterinarians/zootechnical staff. This is especially important in multi-pathogen, multi-user research facilities that study standard and select agent BSL-3 pathogens. The Integrated Services Core will deliver a wide range of high quality BSL-3 and ABSL-3 services for internal users and external collaborators. These will be rigorously overseen by Academic and Service Leads and reviewed annually with the assistance of an external RBL Director, other BSL-3 experts and an internal Scientific Advisory Group. Operational support for the RBL in Pittsburgh will ensure we are ready to support any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.

集成服务核心 摘要： 该大学疫苗研究中心（CVR）内的区域生物防护实验室（RBL） 匹兹堡大学是生物安全3级（BSL-3）感染生物学中心。RBL的使命有三个方面， 致力于病原体的出现、进化和宿主间传播，研究 新出现的传染病，并加快新的干预措施和医疗 预防大流行和生物防御的对策。我们的愿景是成为一个全球公认的，高度- 协作，创造性和前瞻性的感染生物学家团队谁是准备应对新出现的 在国家和国际一级的生物威胁。整个设施都已在 选择代理和毒素（DSAT）。它汇集了来自不同学科的感染生物学家和临床医生 他们需要BSL-3和动物（A）BSL-3设施进行广泛的病毒和细菌研究计划。 生物防护工作操作复杂，基础设施密集，监管全面。运行 BSL-3实验室的安全，可靠和成功的要求有一个组织良好，高度集成 管理人员、科学家、生物安全/生物安保专业人员、工程师/设施工作人员和 兽医/动物技术人员。这在多病原体、多用户研究设施中尤其重要， 研究BSL-3病原体标准和筛选。综合服务核心将提供广泛的 为内部用户和外部合作者提供高质量的BSL-3和ABSL-3服务。这些将严格 由学术和服务领导监督，并在外部RBL的协助下每年进行审查 主任、其他BSL-3专家和一个内部科学咨询小组。对成果预算制的业务支助， 匹兹堡将确保我们准备好支持任何国家应对一系列新出现的传染病 如果发生另一场流行病或生物恐怖袭击。支持这群BSL-3科学家，他们可以 在紧急情况下研究新的病原体，肯定会有回报。