Integrated Services Core

综合服务核心

• 批准号: 10793945
• 负责人: William Paul Duprex
• 金额: $ 115.86万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793945
• 关键词: Acceleration; Administrator; Aerosols; Alphavirus; Animal Model; Animals; Avian Influenza A Virus; Biological; Biology; Bioluminescence; Bioterrorism; Cells; Cellular biology; Clinical; Complex; Confocal Microscopy; Coronavirus; Creativeness; Data; Dimensions; Discipline; Disease model; Emergency Situation; Emerging Communicable Diseases; Engineering; Ensure; Equipment; Event; Evolution; Felis catus; Ferrets; Fluorescence; Hamsters; Immune response; Immunoassay; Immunology procedure; In Vitro; Infection; Infrastructure; International; Intervention; Investments; Laboratories; Laboratory Personnel; Laboratory Research; Laboratory Technicians; Mission; Modeling; Monitor; Mus; Orthobunyavirus; Orthomyxoviridae; Oryctolagus cuniculus; PET/CT scan; Pathogenesis; Pathogenicity; Rattus; Recombinants; Reporter Genes; Reporting; Research; Research Infrastructure; Research Personnel; Rest; Rodent; Running; Scientist; Secure; Services; Side; System; Testing; Therapeutic; Therapeutic Intervention; Tissues; Toxin; Training; Universities; Vaccine Research; Veterinarians; Viral; Vision; Work; arm; biodefense; bioimaging; biosafety level 3 facility; biosecurity; cohort; digital; emerging pathogen; experience; imaging capabilities; in vivo; in vivo imaging; medical countermeasure; multimodality; nonhuman primate; novel; operation; pandemic disease; pandemic preparedness; pathogen; preclinical development; programs; prophylactic; quality assurance; research facility; response; reverse genetics; single cell sequencing; single molecule; single photon emission computed tomography; transmission process; whole body imaging

INTEGRATED SERVICES CORE ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. Biocontainment work is operationally complex, infrastructure-dense, and comprehensively regulated. Running BSL-3 laboratories safely, securely and successfully demands having a well-organized and highly integrated team of administrators, scientists, biosafety/biosecurity professionals, engineers/facilities staff and veterinarians/zootechnical staff. This is especially important in multi-pathogen, multi-user research facilities that study standard and select agent BSL-3 pathogens. The Integrated Services Core will deliver a wide range of high quality BSL-3 and ABSL-3 services for internal users and external collaborators. These will be rigorously overseen by Academic and Service Leads and reviewed annually with the assistance of an external RBL Director, other BSL-3 experts and an internal Scientific Advisory Group. Operational support for the RBL in Pittsburgh will ensure we are ready to support any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.

综合服务核心 抽象的： 大学疫苗研究中心 (CVR) 内的区域生物防护实验室 (RBL) 匹兹堡是感染生物学的生物安全 3 级 (BSL-3) 中心。 RBL 的使命有三个： 致力于病原体的出现、进化和宿主之间的传播，以研究病原体的发病机制 新出现的传染病并加速新型干预措施和医疗的临床前开发 大流行病防范和生物防御的对策。我们的愿景是成为全球认可的、高度 由感染生物学家组成的协作、富有创造力和前瞻性的团队，他们准备应对新出现的问题 国家和国际层面的生物威胁。整个设施已在该部门注册 选择药剂和毒素 (DSAT)。它汇集了来自不同学科的感染生物学家和临床医生 需要 BSL-3 和动物 (A)BSL-3 设施来进行广泛的病毒和细菌研究项目。 生物防护工作操作复杂、基础设施密集且受到全面监管。跑步 BSL-3 实验室的安全、可靠和成功需要拥有一个组织良好、高度集成的实验室 由行政人员、科学家、生物安全/生物安保专业人员、工程师/设施工作人员和 兽医/动物技术人员。这对于多病原体、多用户的研究设施尤其重要，因为 研究标准并选择试剂BSL-3病原体。集成服务核心将提供广泛的 为内部用户和外部合作者提供高质量的 BSL-3 和 ABSL-3 服务。这些都将被严格 由学术和服务主管监督，并在外部 RBL 的协助下每年进行审查 主任、其他 BSL-3 专家和内部科学顾问小组。为 RBL 提供运营支持 匹兹堡将确保我们准备好支持针对一系列新出现的传染病的任何国家应对措施 如果发生另一次流行病或生物恐怖主义袭击。支持这群 BSL-3 科学家，他们可以转向 在紧急情况下研究新的病原体肯定会带来回报。