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Integrated Services Core

综合服务核心

基本信息

批准号：
10793945
负责人：
William Paul Duprex
金额：
$ 115.86万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10793945
关键词：
Acceleration Administrator Aerosols Alphavirus Animal Model Animals Avian Influenza A Virus Biological Biology Bioluminescence Bioterrorism Cells Cellular biology Clinical Complex Confocal Microscopy Coronavirus Creativeness Data Dimensions Discipline Disease model Emergency Situation Emerging Communicable Diseases Engineering Ensure Equipment Event Evolution Felis catus Ferrets Fluorescence Hamsters Immune response Immunoassay Immunology procedure In Vitro Infection Infrastructure International Intervention Investments Laboratories Laboratory Personnel Laboratory Research Laboratory Technicians Mission Modeling Monitor Mus Orthobunyavirus Orthomyxoviridae Oryctolagus cuniculus PET/CT scan Pathogenesis Pathogenicity Rattus Recombinants Reporter Genes Reporting Research Research Infrastructure Research Personnel Rest Rodent Running Scientist Secure Services Side System Testing Therapeutic Therapeutic Intervention Tissues Toxin Training Universities Vaccine Research Veterinarians Viral Vision Work arm biodefense bioimaging biosafety level 3 facility biosecurity cohort digital emerging pathogen experience imaging capabilities in vivo in vivo imaging medical countermeasure multimodality nonhuman primate novel operation pandemic disease pandemic preparedness pathogen preclinical development programs prophylactic quality assurance research facility response reverse genetics single cell sequencing single molecule single photon emission computed tomography transmission process whole body imaging

项目摘要

INTEGRATED SERVICES CORE ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. Biocontainment work is operationally complex, infrastructure-dense, and comprehensively regulated. Running BSL-3 laboratories safely, securely and successfully demands having a well-organized and highly integrated team of administrators, scientists, biosafety/biosecurity professionals, engineers/facilities staff and veterinarians/zootechnical staff. This is especially important in multi-pathogen, multi-user research facilities that study standard and select agent BSL-3 pathogens. The Integrated Services Core will deliver a wide range of high quality BSL-3 and ABSL-3 services for internal users and external collaborators. These will be rigorously overseen by Academic and Service Leads and reviewed annually with the assistance of an external RBL Director, other BSL-3 experts and an internal Scientific Advisory Group. Operational support for the RBL in Pittsburgh will ensure we are ready to support any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.

综合服务核心