Pitt RBL

总体 摘要： 大学疫苗研究中心 (CVR) 内的区域生物防护实验室 (RBL) 匹兹堡是感染生物学的生物安全 3 级 (BSL-3) 中心。 RBL 的使命有三个： 致力于病原体的出现、进化和宿主之间的传播，以研究病原体的发病机制 新出现的传染病并加速新型干预措施和医疗的临床前开发 大流行病防范和生物防御的对策。我们的愿景是成为全球认可的、高度 由感染生物学家组成的协作、富有创造力和前瞻性的团队，他们准备应对新出现的问题 国家和国际层面的生物威胁。整个设施已在该部门注册 选择药剂和毒素 (DSAT)。它汇集了来自不同学科的感染生物学家和临床医生 需要 BSL-3 和动物 (A)BSL-3 设施来进行广泛的病毒和细菌研究项目。 我们建议建立运营、实践和综合服务核心，并正式运营我们的 现有结构。这些都是从 RBL 成立之时起就演变而来的，尽管它们已经服务了 它们的目的需要现代化，以确保它们保持最新状态并在操作上适合目的。的 运营核心将对 RBL 进行全面管理和预算责任。它将管理 每日、每周、每月和每年的 BSL-3 活动对于 RBL 的支持和服务部门至关重要 功能。这将确保 BSL-3 实验室按照最高标准运行和维护，并且它们 安全可靠。实践核心将支持 RBL 的所有基本功能，使科学 严格管理程序并确保整体数据完整性以获得可重复的结果。它将提供 为新 RBL 调查员及其团队提供必要的理论和实践培训 从事 BSL-3 和 ABSL-3 生物防护工作。它将提供生物安全和生物安保支持并保证 工厂符合 1 级精选代理商注册实验室的所有现行合规规定。综合 Services Core 将为内部用户和外部用户提供广泛的高质量 BSL-3 和 ABSL-3 服务 合作者。这些将受到学术和服务主管的严格监督，并每年与 外部 RBL 主任、其他 BSL-3 专家和内部科学咨询小组的协助。 对匹兹堡 RBL 的运营支持将确保我们准备好支持任何国家应对疫情的措施 如果发生另一次大流行或生物恐怖主义袭击，会出现一系列新出现的传染病。支持这个 BSL-3 科学家群体能够在紧急情况下转向研究新的病原体，肯定会带来红利。

OVERALL ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. We propose to establish Operations, Practices and Integrated Services Cores and formally operationalize our existing structures. These have evolved from the time the RBL was established, and although they have served their purpose, require modernization to ensure they will remain current and operationally fit-for-purpose. The Operations Core will have overall management and budgetary responsibility for the RBL. It will administer the daily, weekly, monthly and yearly BSL-3 activities essential for the support and services arms of the RBL to function. This will ensure that the BSL-3 laboratories are run and maintained at the highest standards and they are safe and secure. The Practices Core will support all the basic functions of the RBL enabling scientific programs to be rigorously managed and ensuring overall data integrity for reproducible outcomes. It will provide the requisite theoretical and practical trainings to onboard new RBL Investigators and their teams who wish to work in BSL-3 and ABSL-3 biocontainment. It will provide biosafety and biosecurity support and guarantee the facility meets all current compliance regulations for Tier 1 select agent registered laboratories. The Integrated Services Core will deliver a wide range of high quality BSL-3 and ABSL-3 services for internal users and external collaborators. These will be rigorously overseen by Academic and Service Leads and reviewed annually with the assistance of an external RBL Director, other BSL-3 experts and an internal Scientific Advisory Group. Operational support for the RBL in Pittsburgh will ensure we are ready to support any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.