Pitt RBL

皮特·RBL

• 批准号: 10793942
• 负责人: William Paul Duprex
• 金额: $ 287.02万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793942
• 关键词: Acceleration; Achievement; Animals; Bacteria; Biological; Biology; Biotechnology; Bioterrorism; Cities; Clinical; Collaborations; Communities; Country; County; Creativeness; Development; Discipline; Disease; Emergency Situation; Emerging Communicable Diseases; Ensure; Environment; Equipment; Event; Evolution; Funding; Goals; Health; Health Sciences; Heart; Human; Industrialization; Infection; Infectious Diseases Research; Infrastructure; International; Intervention; Investments; Knowledge; Laboratories; Leadership; Mission; Modernization; Monkeys; Mus; Outcome; Pathogenesis; Play; Process; Recording of previous events; Regulation; Reporting; Reproducibility; Research; Research Activity; Research Personnel; Resources; Role; Running; Scientist; Secure; Services; Strategic Planning; Structure; Support System; System; Therapeutic antibodies; Time; Toxin; Training; Training Support; Translating; Universities; Vaccine Research; Vaccines; Viral; Virus; Vision; Work; arm; biodefense; biosafety level 3 facility; biosecurity; cohort; data integrity; emerging pathogen; fighting; flexibility; future pandemic; high standard; medical countermeasure; medical schools; meetings; nanobodies; novel; operation; pandemic disease; pandemic preparedness; pathogen; pre-clinical; preclinical development; prevent; programs; prototype; response; small molecule inhibitor; success; transmission process

OVERALL ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. We propose to establish Operations, Practices and Integrated Services Cores and formally operationalize our existing structures. These have evolved from the time the RBL was established, and although they have served their purpose, require modernization to ensure they will remain current and operationally fit-for-purpose. The Operations Core will have overall management and budgetary responsibility for the RBL. It will administer the daily, weekly, monthly and yearly BSL-3 activities essential for the support and services arms of the RBL to function. This will ensure that the BSL-3 laboratories are run and maintained at the highest standards and they are safe and secure. The Practices Core will support all the basic functions of the RBL enabling scientific programs to be rigorously managed and ensuring overall data integrity for reproducible outcomes. It will provide the requisite theoretical and practical trainings to onboard new RBL Investigators and their teams who wish to work in BSL-3 and ABSL-3 biocontainment. It will provide biosafety and biosecurity support and guarantee the facility meets all current compliance regulations for Tier 1 select agent registered laboratories. The Integrated Services Core will deliver a wide range of high quality BSL-3 and ABSL-3 services for internal users and external collaborators. These will be rigorously overseen by Academic and Service Leads and reviewed annually with the assistance of an external RBL Director, other BSL-3 experts and an internal Scientific Advisory Group. Operational support for the RBL in Pittsburgh will ensure we are ready to support any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.

全面的 抽象的： 大学疫苗研究中心（CVR）内的区域生物内在实验室（RBL） 匹兹堡的属于感染生物学的生物安全3级（BSL-3）中心。 RBL的任务是三倍， 在病原体出现，进化和宿主传播方面的工作，以研究 新兴的传染病，并加速新的干预措施和医学的临床前发展 大流行准备和生物陷入困境的对策。我们的愿景是成为全球认可的，高度的 - 准备回应新兴的感染生物学家的合作，创造性和正面的感染生物学家团队 国家和国际层面都有生物威胁。整个设施已在部门注册 选择剂和毒素（DSAT）。它汇集了来自各种学科的感染生物学家和临床医生 他们需要BSL-3和动物（A）BSL-3设施来进行广泛的病毒和细菌研究计划。 我们建议建立运营，实践和综合服务核心，并正式运营我们的 现有结构。这些从建立RBL开始就发展了，尽管它们已经服务 他们的目的是需要现代化，以确保它们将保持最新且在操作上拟合使用。这 操作核心将对RBL负面管理和预算责任。它将管理 每日，每周，每月和每年的BSL-3 3活动对于RBL的支持和服务武器至关重 功能。这将确保BSL-3实验室以最高标准运行和维护 是安全的。实践核心将支持RBL的所有基本功能 严格管理的程序并确保可再现结果的总体数据完整性。它将提供 希望在新的RBL调查人员及其团队的必要理论和实用培训中 在BSL-3和ABSL-3生物膜片中工作。它将提供生物安全和生物安全支持，并保证 设施符合第1级专家注册实验室的所有当前合规法规。集成 服务核心将为内部用户和外部提供广泛的高质量BSL-3和ABSL-3服务 合作者。这些将由学术和服务线索严格监督，并每年与 外部RBL主管，其他BSL-3专家和内部科学咨询小组的协助。 匹兹堡RBL的运营支持将确保我们准备支持任何国家的回应 在另一种大流行或生物恐怖袭击时，新兴的传染病范围范围。支持这个 BSL-3科学家的队列肯定会带来股息。