Operations Core

运营核心

• 批准号: 10793943
• 负责人: William Paul Duprex
• 金额: $ 98.46万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793943
• 关键词: Acceleration; Address; Adherence; Administrator; Animals; Biological; Biology; Bioterrorism; Businesses; Certification; Collaborations; Complex; Creativeness; Decontamination; Development; Discipline; Effectiveness; Emergency Situation; Emerging Communicable Diseases; Engineering; Ensure; Environmental Health; Event; Evolution; Goals; Human Resources; Infection; Information Technology; Infrastructure; International; Intervention; Laboratories; Laboratory Animals; Logistics; Maintenance; Mission; Modeling; Modernization; Monitor; National Institute of Allergy and Infectious Disease; Pathogenesis; Regulation; Research; Research Activity; Rest; Running; Safety; Scientist; Secure; Security; Services; Structure; System; Time; Toxin; Universities; Vaccine Research; Veterinarians; Viral; Vision; Work; animal resource; arm; biodefense; biosafety level 3 facility; biosecurity; cohort; cost; emerging pathogen; high standard; improved; medical countermeasure; member; novel; operation; pandemic disease; pandemic preparedness; pathogen; preclinical development; pressure; programs; quality assurance; repaired; research facility; response; transmission process

OPERATIONS CORE ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. The Operations Core will be responsible for the formal operationalization and development of our existing structures. These have evolved from the time the RBL was established, and although they have served their purpose, require modernization to ensure they will remain current and operationally fit-for-purpose. Biocontainment work is operationally complex, infrastructure-dense, and comprehensively regulated. Running BSL-3 laboratories safely, securely and successfully demands having a well-organized and highly integrated team of administrators, scientists, biosafety/biosecurity professionals, engineers/facilities staff and veterinarians/zootechnical staff. This is especially important in multi-pathogen, multi-user research facilities that study standard and select agent BSL-3 pathogens. The Operations Core will provide overall management and budgetary responsibility for the RBL. It will administer the daily, weekly, monthly and yearly BSL-3 activities essential for the support and services arms of the RBL to function. This will ensure that the BSL-3 laboratories are run and maintained at the highest standards and they are safe and secure. Operational support for the RBL in Pittsburgh will ensure we are ready to support any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.

运营核心 摘要： 该大学疫苗研究中心（CVR）内的区域生物防护实验室（RBL） 匹兹堡大学是生物安全3级（BSL-3）感染生物学中心。RBL的使命有三个方面， 致力于病原体的出现、进化和宿主间传播，研究 新出现的传染病，并加快新的干预措施和医疗 预防大流行和生物防御的对策。我们的愿景是成为一个全球公认的，高度- 协作，创造性和前瞻性的感染生物学家团队谁是准备应对新出现的 在国家和国际一级的生物威胁。整个设施都已在 选择代理和毒素（DSAT）。它汇集了来自不同学科的感染生物学家和临床医生 他们需要BSL-3和动物（A）BSL-3设施进行广泛的病毒和细菌研究计划。 运营核心将负责我们现有的 结构.这些都是从RBL成立的时候演变而来的，虽然他们已经为他们的 为了达到这一目的，需要进行现代化，以确保它们保持最新状态，并在业务上适合这一目的。 生物防护工作操作复杂，基础设施密集，监管全面。运行 BSL-3实验室的安全，可靠和成功的要求有一个组织良好，高度集成 管理人员、科学家、生物安全/生物安保专业人员、工程师/设施工作人员和 兽医/动物技术人员。这在多病原体、多用户研究设施中尤其重要， 研究BSL-3病原体标准和筛选。业务核心将提供全面管理， 对RBL的预算责任。它将管理每日、每周、每月和每年的BSL-3活动 这对RBL的支持和服务部门发挥作用至关重要。这将确保BSL-3实验室 以最高标准运行和维护，并且安全可靠。对区域预算清单的业务支助 在匹兹堡举行的会议将确保我们准备好支持任何国家对一系列新出现的传染病的反应。 在另一次大流行或生物恐怖袭击的情况下，支持这一组BSL-3科学家，他们 可以在紧急情况下转向研究新的病原体，这肯定会带来回报。