Interpreting and Deploying Genomic Information During Animal Development

动物发育过程中基因组信息的解释和应用

基本信息

  • 批准号:
    10810331
  • 负责人:
  • 金额:
    $ 1.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-05-03 至 2026-04-30
  • 项目状态:
    未结题

项目摘要

Summary The long term goal of this project is to understand how members of large transcription factor families, which share a DNA binding domain and typically have very similar DNA binding specificities, execute highly specific functions in vivo. The primary focus of this proposal is on the Hox family of homeodomain transcription factors, which play critical roles during animal embryogenesis, organ development, and appendage specification in both vertebrates and invertebrates. When these transcription factors mis-regulate their target genes, either due to mutations in their protein-coding sequences or in their target DNA binding sites, developmental defects and many human diseases, from cancer to diabetes, can result. For the next funding period this project will bridge the gap between understanding how these factors specifically recognize their binding sites in vitro, often in conjunction with cofactors, and how they execute their specific functions in vivo. This will be accomplished using whole genome approaches with tagged and mutant Hox factors and by visualizing these proteins and their binding sites in living cells. Additional efforts will be to identify and characterize newly discovered novel cofactors and mechanisms, such as post-translational modifications of Hox proteins, that can alter their DNA binding specificities and/or transcriptional regulatory activities in vivo. In all cases, these experiments will be grounded in identifying and understanding how Hox proteins regulate their bona fide target genes, which allow them to orchestrate entire developmental programs, such as the development of legs and wings.
总结

项目成果

期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Fluorescent labeling of genomic loci in Drosophila imaginal discs with heterologous DNA-binding proteins.
  • DOI:
    10.1016/j.crmeth.2022.100175
  • 发表时间:
    2022-03-28
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Homothorax controls a binary Rhodopsin switch in Drosophila ocelli.
  • DOI:
    10.1371/journal.pgen.1009460
  • 发表时间:
    2021-07
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
    Mishra AK;Fritsch C;Voutev R;Mann RS;Sprecher SG
  • 通讯作者:
    Sprecher SG
Divergent expression of paralogous genes by modification of shared enhancer activity through a promoter-proximal silencer.
  • DOI:
    10.1016/j.cub.2022.06.069
  • 发表时间:
    2022-08-22
  • 期刊:
  • 影响因子:
    9.2
  • 作者:
    Loker, Ryan;Mann, Richard S.
  • 通讯作者:
    Mann, Richard S.
Robust ΦC31-Mediated Genome Engineering in Drosophila melanogaster Using Minimal attP/attB Phage Sites.
  • DOI:
    10.1534/g3.118.200051
  • 发表时间:
    2018-05-04
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Voutev R;Mann RS
  • 通讯作者:
    Mann RS
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

RICHARD S MANN其他文献

RICHARD S MANN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('RICHARD S MANN', 18)}}的其他基金

Project 2: Neural Basis of Motor Pattern Control Loops
项目 2:运动模式控制环路的神经基础
  • 批准号:
    10202762
  • 财政年份:
    2017
  • 资助金额:
    $ 1.15万
  • 项目类别:
Interpreting and Deploying Genomic Information During Animal Development
动物发育过程中基因组信息的解释和应用
  • 批准号:
    10383722
  • 财政年份:
    2016
  • 资助金额:
    $ 1.15万
  • 项目类别:
Interpreting and Deploying Genomic Information During Animal Development
动物发育过程中基因组信息的解释和应用
  • 批准号:
    10170944
  • 财政年份:
    2016
  • 资助金额:
    $ 1.15万
  • 项目类别:
Interpreting and Deploying Genomic Information During Animal Development
动物发育过程中基因组信息的解释和应用
  • 批准号:
    10620140
  • 财政年份:
    2016
  • 资助金额:
    $ 1.15万
  • 项目类别:
Interpreting and Deploying Genomic Information During Animal Development
动物发育过程中基因组信息的解释和应用
  • 批准号:
    9923659
  • 财政年份:
    2016
  • 资助金额:
    $ 1.15万
  • 项目类别:
Genetic dissection of locomotion
运动的基因剖析
  • 批准号:
    8752141
  • 财政年份:
    2014
  • 资助金额:
    $ 1.15万
  • 项目类别:
Development and function of an adult locomotion circuit in Drosophila
果蝇成体运动回路的发育和功能
  • 批准号:
    10361422
  • 财政年份:
    2010
  • 资助金额:
    $ 1.15万
  • 项目类别:
Development and Function of an Adult Locomotion Circuit in Drosophila
果蝇成体运动回路的发育和功能
  • 批准号:
    10581590
  • 财政年份:
    2010
  • 资助金额:
    $ 1.15万
  • 项目类别:
Development and function of an adult locomotion circuit in Drosophila
果蝇成体运动回路的发育和功能
  • 批准号:
    8331731
  • 财政年份:
    2010
  • 资助金额:
    $ 1.15万
  • 项目类别:
Development and function of an adult locomotion circuit in Drosophila
果蝇成体运动回路的发育和功能
  • 批准号:
    8239896
  • 财政年份:
    2010
  • 资助金额:
    $ 1.15万
  • 项目类别:

相似国自然基金

多模态超声VisTran-Attention网络评估早期子宫颈癌保留生育功能手术可行性
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    30 万元
  • 项目类别:
    青年科学基金项目
Ultrasomics-Attention孪生网络早期精准评估肝内胆管癌免疫治疗的研究
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    52 万元
  • 项目类别:
    面上项目

相似海外基金

Development of social attention indicators of emerging technologies and science policies with network analysis and text mining
利用网络分析和文本挖掘开发新兴技术和科学政策的社会关注指标
  • 批准号:
    24K16438
  • 财政年份:
    2024
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Improving Flexible Attention to Numerical and Spatial Magnitudes in Young Children
提高幼儿对数字和空间大小的灵活注意力
  • 批准号:
    2410889
  • 财政年份:
    2024
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Continuing Grant
The Information-Attention Tradeoff: Toward an Understanding of the Fundamentals of Online Attention
信息与注意力的权衡:了解在线注意力的基本原理
  • 批准号:
    2343858
  • 财政年份:
    2024
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Continuing Grant
The everyday learning opportunities of young children with attention and motor difficulties: From understanding constraints to reshaping intervention
注意力和运动困难幼儿的日常学习机会:从理解限制到重塑干预
  • 批准号:
    MR/X032922/1
  • 财政年份:
    2024
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Fellowship
Towards a cognitive process model of how attention and choice interact
建立注意力和选择如何相互作用的认知过程模型
  • 批准号:
    DP240102605
  • 财政年份:
    2024
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Discovery Projects
DDRIG in DRMS: Communicating risks in a sensational media environment-Using short video multimodal features to attract attention and reduce psychological reactance for persuasion
DRMS中的DDRIG:耸人听闻的媒体环境中沟通风险——利用短视频多模态特征吸引注意力,减少说服心理抵触
  • 批准号:
    2343506
  • 财政年份:
    2024
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Standard Grant
Assessing the Influence of Reading Fiction on Multiple Tests of Attention
评估阅读小说对注意力多重测试的影响
  • 批准号:
    24K16033
  • 财政年份:
    2024
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
CAREER: Designing Ultra-Energy-Efficient Intelligent Hardware with On-Chip Learning, Attention, and Inference
职业:设计具有片上学习、注意力和推理功能的超节能智能硬件
  • 批准号:
    2336012
  • 财政年份:
    2023
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Continuing Grant
CPS: Small: Brain-Inspired Memorization and Attention for Intelligent Sensing
CPS:小:智能传感的受大脑启发的记忆和注意力
  • 批准号:
    2312517
  • 财政年份:
    2023
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Standard Grant
CAREER: Understanding the Relationship of Covert and Overt Attention Using Concurrent EEG and Eye Tracking
职业:使用并发脑电图和眼动追踪了解隐性注意力和显性注意力的关系
  • 批准号:
    2345898
  • 财政年份:
    2023
  • 资助金额:
    $ 1.15万
  • 项目类别:
    Continuing Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了