Control of Repetitive Movement in Parkinson's Disease
控制帕金森病的重复运动
基本信息
- 批准号:7591603
- 负责人:
- 金额:$ 32.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-05-25 至 2011-04-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAreaBasal GangliaBradykinesiaBrainClinicalCuesDeep Brain StimulationDeteriorationDisease ProgressionDistalDyskinetic syndromeElectrodesElectroencephalographyFingersFrequenciesFunctional disorderGlobus PallidusGoalsHumanImpairmentImplantImplanted ElectrodesIndividualLevodopaMeasuresMetabolicMethodsMotorMotor CortexMovementMovement DisordersNeuronsOutputParkinson DiseasePathway interactionsPatientsPatternPerformancePharmaceutical PreparationsPopulationProductionPublic HealthQuality of lifeRehabilitation therapyResearch PersonnelResolutionRoleSTN stimulationScalp structureSecondary toSeveritiesStructureStructure of subthalamic nucleusSurfaceSymptomsTechniquesTestingTherapeuticTimeUnited StatesUpper ExtremityWorkawakebasedensitydesigneffective therapyfrontal lobeimpressionimprovednervous system disorderneurophysiologyprogramsresearch study
项目摘要
Parkinson's disease (PD) affects more than a million people in the United States. Voluntary movement in
these patients is characterized by slowness and reduced movement amplitude (bradykinesia) and a lack of
spontaneous volitional movement (akinesia). The severity of bradykinesia increases with disease
progression and has a significant impact on quality of life. Bradykinesia is most evident during the
performance of fast repetitive movements and worsened when external cues are removed. The purpose of
this project is to examine the mechanisms contributing to impaired repetitive movement in patients with PD
and the effects of the two most successful treatments for PD, levodopa and high frequency stimulation of the
subthalamic nucleus (STN-DBS), on these mechanisms. The first specific aim will examine the effects of
movement cueing (external vs. internal cues), frequency (0.8 Hz vs. 2 Hz) and levodopa on repetitive finger
movement and movement-related cortical oscillations recorded using electroencephalography (EEC). The
second specific aim will examine the effects of the same factors (cueing, movement frequency and
levodopa) on the patterns of movement-related activity in the basal ganglia (a group of deep brain structures)
of awake patients with PD. Basal ganglia activity will be recorded from electrodes implanted in the
subthalamic nucleus (STN) of patients with PD. The third specific aim will compare the effects of levodopa
versus STN-DBS on movement-related cortical oscillations. High-resolution EEC recordings of motor cortical
activity will be used to examine how these treatments affect repetitive movement. These experiments will be
the first to examine the neurophysiological basis for the deterioration of motor performance during repetitive
movements in PD and the cortical mechanisms by which levodopa and STN-DBS improve the performance
of these movements. The long-term goals of this project are twofold: to develop improved rehabilitation
techniques that take advantage of factors that facilitate movement performance and to develop improved
methods for the delivery of deep brain stimulation. Dysfunction of the basal ganglia is implicated in a variety
of neurological disorders, including PD, that affect a large segment of the US population. This project is
relevant to public health because the findings will provide a better understanding of the human basal ganglia
and its role in the production of disordered movement and help to develop improved treatments.
帕金森病(PD)影响了美国超过一百万人。自愿运动
这些患者的特征是缓慢和运动幅度降低(运动迟缓),
自发性意志运动(运动不能)。运动迟缓的严重程度随着疾病的增加而增加
并对生活质量产生重大影响。运动迟缓最明显的是在
快速重复动作的表现,当外部线索被去除时会恶化。的目的
本研究旨在探讨帕金森病患者重复运动受损的机制
以及两种最成功的PD治疗方法,左旋多巴和高频刺激的效果。
丘脑底核(STN-DBS),对这些机制。第一个具体目标将审查
运动提示(外部与内部提示)、频率(0.8 Hz与2 Hz)和重复手指上的左旋多巴
运动和运动相关的皮层振荡记录使用脑电图(EEC)。的
第二个具体目标将检查相同因素(提示,运动频率和
左旋多巴)对基底神经节(一组脑深部结构)运动相关活动模式的影响
清醒的帕金森病患者基底神经节活动将由植入基底神经节的电极记录。
丘脑底核(subthalamic nucleus,简称FDN)。第三个具体目标将比较左旋多巴的效果
对比STN-DBS对运动相关皮层振荡的影响。运动皮层的高分辨率EEC记录
活动将被用来检查这些治疗如何影响重复运动。这些实验将
第一个研究神经生理学基础的运动性能的恶化,在重复性
PD的运动和左旋多巴和STN-DBS改善性能的皮质机制
这些运动。该项目的长期目标有两个:
技术,利用促进运动表现的因素,并发展改善
用于递送深部脑刺激的方法。基底神经节功能障碍与多种
包括PD在内的神经系统疾病,影响了美国大部分人口。这个项目是
与公共卫生有关,因为这些发现将更好地了解人类基底神经节
以及它在产生运动障碍中的作用,并有助于开发更好的治疗方法。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Suppression of deep brain stimulation artifacts from the electroencephalogram by frequency-domain Hampel filtering.
- DOI:10.1016/j.clinph.2010.02.156
- 发表时间:2010-08
- 期刊:
- 影响因子:0
- 作者:Allen DP;Stegemöller EL;Zadikoff C;Rosenow JM;Mackinnon CD
- 通讯作者:Mackinnon CD
Altered premotor cortical oscillations during repetitive movement in persons with Parkinson's disease.
- DOI:10.1016/j.bbr.2016.09.036
- 发表时间:2017-01-15
- 期刊:
- 影响因子:2.7
- 作者:Stegemöller EL;Allen DP;Simuni T;MacKinnon CD
- 通讯作者:MacKinnon CD
The effects of Parkinson's disease and age on syncopated finger movements.
- DOI:10.1016/j.brainres.2009.06.099
- 发表时间:2009-09-22
- 期刊:
- 影响因子:2.9
- 作者:Stegemöller EL;Simuni T;Mackinnon CD
- 通讯作者:Mackinnon CD
Time-frequency analysis of movement-related spectral power in EEG during repetitive movements: a comparison of methods.
- DOI:10.1016/j.jneumeth.2009.10.022
- 发表时间:2010-01-30
- 期刊:
- 影响因子:3
- 作者:Allen, David P.;MacKinnon, Colum D.
- 通讯作者:MacKinnon, Colum D.
Deep brain stimulation improves movement amplitude but not hastening of repetitive finger movements.
- DOI:10.1016/j.neulet.2013.07.056
- 发表时间:2013-09-27
- 期刊:
- 影响因子:2.5
- 作者:Stegemöller EL;Zadikoff C;Rosenow JM;Mackinnon CD
- 通讯作者:Mackinnon CD
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COLUM D MACKINNON其他文献
COLUM D MACKINNON的其他文献
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{{ truncateString('COLUM D MACKINNON', 18)}}的其他基金
Neuroplasticity and the emergence of motor and cognitive deficits in prodromal synucleinopathy
前驱期突触核蛋白病的神经可塑性以及运动和认知缺陷的出现
- 批准号:
10419719 - 财政年份:2022
- 资助金额:
$ 32.81万 - 项目类别:
Mechanisms and effects of pallidal deep brain stimulation on levodopa resistant motor signs in Parkinson's disease
苍白球深部脑刺激对帕金森病左旋多巴抵抗运动体征的机制和影响
- 批准号:
10282963 - 财政年份:2021
- 资助金额:
$ 32.81万 - 项目类别:
Mechanisms and effects of pallidal deep brain stimulation on levodopa resistant motor signs in Parkinson's disease
苍白球深部脑刺激对帕金森病左旋多巴抵抗运动体征的机制和影响
- 批准号:
10703246 - 财政年份:2021
- 资助金额:
$ 32.81万 - 项目类别:
Mechanisms and effects of pallidal deep brain stimulation on levodopa resistant motor signs in Parkinson's disease
苍白球深部脑刺激对帕金森病左旋多巴抵抗运动体征的机制和影响
- 批准号:
10489834 - 财政年份:2021
- 资助金额:
$ 32.81万 - 项目类别:
Predictors of progression to freezing of gait in Parkinson's disease
帕金森病进展为冻结步态的预测因子
- 批准号:
9132362 - 财政年份:2015
- 资助金额:
$ 32.81万 - 项目类别:
Mechanisms of Movement Facilitation and Release by Cueing in Parkinson's disease
帕金森病中提示的运动促进和释放机制
- 批准号:
8542905 - 财政年份:2011
- 资助金额:
$ 32.81万 - 项目类别:
Mechanisms of Movement Facilitation and Release by Cueing in Parkinson's disease
帕金森病中提示的运动促进和释放机制
- 批准号:
8188218 - 财政年份:2011
- 资助金额:
$ 32.81万 - 项目类别:
Mechanisms of Movement Facilitation and Release by Cueing in Parkinson's disease
帕金森病中提示的运动促进和释放机制
- 批准号:
8325009 - 财政年份:2011
- 资助金额:
$ 32.81万 - 项目类别:
Control of Repetitive Movement in Parkinson's Disease
控制帕金森病的重复运动
- 批准号:
7413271 - 财政年份:2006
- 资助金额:
$ 32.81万 - 项目类别:
Control of Repetitive Movement in Parkinson's Disease
控制帕金森病的重复运动
- 批准号:
7236186 - 财政年份:2006
- 资助金额:
$ 32.81万 - 项目类别:
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