Impact of Marijuana Legalization: Comparison of Two Longitudinal Twin Cohorts

大麻合法化的影响：两个纵向双胞胎群体的比较

• 批准号: 9402524
• 负责人: JOHN K. HEWITT
• 金额: $ 112.6万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9402524
• 关键词: 21 year old; Adolescence; Adult; Advocate; Affect; Age; Alcohol or Other Drugs use; Alcohols; Behavioral; Clinical; Colorado; Data; Dependence; Development; Environmental Monitoring; Event; Exposure to; Family; Frequencies; Functional disorder; Gender; Genetic; Genetic Predisposition to Disease; Genetic Risk; Geographic state; Health; Home environment; Illicit Drugs; Individual; Individual Differences; Industry; Laws; Legal; Life; Marijuana; Marijuana Dependence; Measurement; Measures; Medical Marijuana; Mental Health; Mental disorders; Minnesota; Mutation; Natural experiment; Nicotine; Outcome; Pattern; Policies; Population; Prevalence; Property; Psychological adjustment; Psychopathology; Public Health; Recreational Drugs; Research; Risk; Role; Sample Size; Sampling; Severities; Side; Social Impacts; Structure; Substance Addiction; Substance Use Disorder; Testing; Time; Twin Multiple Birth; Twin Studies; Work; alcohol availability; base; cohort; design; early adolescence; emerging adult; environmental change; experience; falls; follow up assessment; gender difference; high risk; marijuana legalization; marijuana use; marijuana use disorder; pill; population based; prospective; psychologic; psychosocial; resilience

PROJECT ABSTRACT We propose to examine the impact of recreational marijuana legalization on the development of marijuana use and marijuana use disorders, alcohol, nicotine, and other substance use and use disorders, and associated psychological adjustment and psychopathology. To do this, we will compare outcomes in two population based twin samples that have been followed longitudinally for over 15 years since adolescence. The age ranges of the samples at will be 23-39 at their follow-up assessment, thus, we will be able to examine the impact of legalization on early- to mid-adulthood functioning of family formation, work engagement, and adult role fulfillment. We will obtain additional waves of data in these samples in order to examine the effect of legalization on rates of marijuana, alcohol and other substance use and use disorders as well as associated psychological adjustment and psychopathology. One of these samples is from Colorado, which legalized adult recreational marijuana use in 2014 and now has widespread commercial marijuana readily available to consumers. The other sample is from Minnesota, which in 2014 legalized medical marijuana, with very strict limits on access, and has no recreational legalization. Together with our detailed prior longitudinal data, the new assessments, post-legalization of substance use, psychopathology, and psychosocial functioning in over 5000 population-based adult twins will provide unique and powerful data to understand the impact of recreational marijuana legalization and marijuana use on a wide variety of important outcomes. Furthermore, the effect of recreational marijuana legalization is unlikely to be uniform across the population. Rather, some individuals will be at higher risk to suffer negative consequences of RML, such as increased use and dependence. Leveraging the longitudinal and twin structure of the study, we will be able to determine the influence of pre-legalization individual differences in behavioral risk and psychosocial function on the effect of recreational marijuana legalization.

项目摘要 我们建议研究娱乐性大麻合法化对大麻使用发展的影响 和大麻使用障碍，酒精，尼古丁和其他物质使用和使用障碍，以及相关的 心理适应和精神病理学。为此，我们将比较两个基于 从青春期开始纵向跟踪超过15年的双胞胎样本。年龄范围 在后续评估中，样本将为23-39，因此，我们将能够检查 将家庭形成、工作参与和成人角色的早期至中期成年功能合法化 满足感我们将在这些样本中获得额外的数据波，以检查 大麻、酒精和其他物质使用率和使用障碍以及相关的合法化 心理适应和精神病理学。其中一个样本来自科罗拉多州，该州将成人合法化 2014年，娱乐性大麻的使用，现在有广泛的商业大麻， 消费者另一个样本来自明尼苏达州，该州在2014年将医用大麻合法化， 限制访问，没有娱乐合法化。结合我们之前详细的纵向数据， 新的评估，药物使用合法化后，精神病理学和心理社会功能， 5000个基于人口的成年双胞胎将提供独特而强大的数据，以了解 娱乐性大麻合法化和大麻使用对各种各样的重要结果。此外，委员会认为， 娱乐用大麻合法化的效果不太可能在整个人口中是一致的。相反，一些 个人将面临更高的风险遭受RML的负面后果，如增加使用， 依赖利用研究的纵向和孪生结构，我们将能够确定 合法化前行为风险和心理社会功能的个体差异对 娱乐用大麻合法化