Research Training - Genetics of Substance Abuse

描述（由申请人提供）：该提案正在寻求持续的支持，通过机构培训补助金，为博士前和博士后研究员提供培训计划，他们将从事专注于药物滥用遗传影响研究的研究事业。IBG的教师是杰出的，积极的研究和IBG的科学家们积极追求的遗传对药物滥用的影响超过45年的研究。与药物滥用有关的主要研究项目目前正在人类和动物行为遗传学方面取得进展。生物统计学、统计学和定量遗传学技术的应用，以及生物信息学、全基因组分析和下一代测序以及表观遗传学，正在为我们的理解提供真实的进步。神经化学、神经药理学、神经生理学和分子遗传学的研究，提供了对与行为相关的基因功能的理解。人类和动物行为遗传学方面的主要研究项目正在进行中，包括大规模的国家合作研究，积累了DNA储存库和丰富的表型数据集，可用于药物滥用研究。设施可用于基因型测定，包括全基因组测定，基因功能和表达研究，以及行为，生物化学和神经生理学研究。申请资助4名博士前和2名博士后学员。博士预科生获得合作学术单位的博士学位和行为遗传学证书。培训计划的学术要求包括行为遗传学，定量和生物统计遗传学，理论和基于计算机的统计学，分子遗传学，神经科学，生物信息学和基因组学，负责任的研究行为以及行为和临床表型课程的培训。附加要求根据学位授予学术单位而有所不同。研究经验是培训的一个组成部分。博士后学员也追求一个正式的计划，强调个人研究以及在分子和定量行为遗传学的能力。为药物滥用研究职业做准备的其他活动包括：监督学生和/或技术人员，接待研讨会发言人，客座演讲，每周杂志俱乐部，以及负责任地进行研究和制定个人专业计划的强制性培训。

DESCRIPTION (provided by applicant): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBG faculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 45 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in our understanding. Neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays, gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory training in the responsible conduct of research and the development of individual professional plans.