Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 8479326
• 负责人: JOHN K. HEWITT
• 金额: $ 28.6万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8479326
• 关键词: Genetic; Research Training; Substance abuse problem

Seeinstructions): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBGfaculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 40 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques and the development of quantitative trait loci methods allow the mapping and identification of genes that regulate complex traits. Information from such analyses, along with neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, will provide an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays,gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees over a total period of 5 years. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory attendance in a course on the responsible conduct of research. RELEVANCE (See instructions): This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to the vulnerability to develop substance abuse. This understanding will lead to new approaches to the prevention and alleviation of substance abuse.

参见说明）： 这项提案正在寻求通过机构培训赠款继续支持一项学前教育培训方案， 和博士后研究员，他们将从事研究事业，重点是研究基因对人类的影响。 滥用药物IBG教师是杰出的，积极的研究和IBG科学家积极 40多年来一直致力于研究基因对药物滥用的影响。与主要药物滥用有关的 人类和动物行为遗传学的研究项目正在进行中。的应用 生物统计学、统计学和数量遗传学技术以及数量性状基因座的发展 这些方法允许对调控复杂性状的基因进行定位和鉴定。信息从这样的 分析，沿着神经化学，神经药理学，神经生理学和分子遗传学 研究，将提供与行为相关的基因功能的理解。目前，主要研究项目 人类和动物行为遗传学的进展，包括大规模的国家合作研究 为药物滥用的研究积累DNA库和丰富的表型数据集。设施 可用于基因型分析，包括全基因组分析、基因功能和表达研究， 行为、生物化学和神经生理学研究。资金要求支持4个博士预科和2个 博士后研究生的总期限为5年。博士预科学员获得博士学位， 合作学术单位和行为遗传学认证。培训中的学术要求 计划包括行为遗传学，定量和生物统计遗传学，理论和 计算机化统计、分子遗传学、生物信息学和基因组学， 研究，以及行为和临床表型课程。附加要求根据 学位授予学术单位研究经验是培训的一个组成部分。博士后研究生也 追求一个正式的计划，强调个人的研究以及在分子和 定量行为遗传学在心理健康的研究生涯准备的其他活动包括： 监督学生和/或技术人员，主持研讨会发言人，客座演讲，每周杂志 俱乐部，并强制参加关于负责任地进行研究的课程。 相关性（参见说明）： 这项建议是为了培养科学家，他们将能够为我们对遗传学的理解做出重大贡献。 导致药物滥用的脆弱性。这种理解将导致新的 预防和减轻药物滥用的方法。