Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 8479326
• 负责人: JOHN K. HEWITT
• 金额: $ 28.6万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8479326
• 关键词: Genetic; Research Training; Substance abuse problem

Seeinstructions): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBGfaculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 40 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques and the development of quantitative trait loci methods allow the mapping and identification of genes that regulate complex traits. Information from such analyses, along with neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, will provide an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays,gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees over a total period of 5 years. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory attendance in a course on the responsible conduct of research. RELEVANCE (See instructions): This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to the vulnerability to develop substance abuse. This understanding will lead to new approaches to the prevention and alleviation of substance abuse.

see Instructions）： 该建议是通过机构培训补助金寻求持续支持 和博士后研究员将从事研究职业，重点是研究遗传影响的研究 药物滥用。 IBGFFACTULTY在研究方面很有区别和活跃，IBG科学家已经积极 对遗传对药物滥用的影响进行了40多年的研究。主要药物滥用有关 人类和动物行为遗传学的研究项目正在进行中。应用 生物识别，统计和定量遗传技术以及定量性状基因座的发展 方法允许映射和识别调节复杂性状的基因。来自此的信息 分析以及神经化学，神经药物，神经生理学和分子遗传 研究将提供对与行为相关的基因功能的理解。现在的主要研究项目 人类和动物行为遗传学的进展，包括大规模的国家合作研究 积聚DNA存储库和丰富的表型数据集可用于研究药物滥用。设施 可用于基因型测定法，包括全基因组测定，基因功能和表达研究，以及 行为，生化和神经生理学研究。要求资金支持4个五次和2 博士后学员在总计5年内。托管前学员获得博士学位 在行为遗传学方面合作学术单位和认证。培训中的学术要求 计划包括行为遗传学，定量和生物遗传学，理论和理论和生物遗传学培训 基于计算机的统计数据，分子遗传学，生物信息学和基因组学，负责任的行为 研究以及有关行为和临床表型的课程。其他要求根据 学位授予学术单位。研究经验是培训的组成部分。博士后学员 追求一个正式的计划，该计划强调个人研究以及分子的能力 定量行为遗传学。为心理健康研究事业做准备的其他活动包括： 对学生和/或技术人员的监督，主持研讨会的演讲者，客人讲课，每周杂志 俱乐部，以及在负责任的研究课程中强制参加。 相关性（请参阅说明）： 该建议是培训能够为我们对遗传的理解做出重大贡献的科学家 对发展药物滥用的脆弱性的贡献。这种理解将导致新 预防和减轻药物滥用的方法。