Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 9457003
• 负责人: JOHN K. HEWITT
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9457003
• 关键词: Genetic; Research Training; Substance abuse problem

DESCRIPTION (provided by applicant): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBG faculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 45 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in our understanding. Neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays, gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory training in the responsible conduct of research and the development of individual professional plans.

描述(由申请人提供)：这项提案正在寻求通过机构培训赠款为博士后和博士后研究员提供培训计划的持续支持，这些博士后研究员将从事专注于研究基因对药物滥用的影响的研究生涯。IBG的教职员工是杰出的和活跃的研究，IBG的科学家在超过45年的时间里一直积极研究遗传对药物滥用的影响。与药物滥用有关的重大研究项目目前正在人类和动物行为遗传学方面进行。生物统计学、统计学和定量遗传技术的应用，以及生物信息学、全基因组分析和下一代测序以及表观遗传学，正在为我们的理解提供真正的进步。神经化学、神经药理学、神经生理学和分子遗传学研究正在提供对与行为相关的基因功能的理解。人类和动物行为遗传学的主要研究项目目前都在进行中，包括大规模的国家合作研究，积累了可用于药物滥用研究的DNA储存库和丰富的表型数据集。可用于基因分析的设备，包括全基因组分析、基因功能和表达研究，以及行为、生化和神经生理学研究。请拨资金支持4名博士后和2名博士后实习生。博士前实习生获得合作学术单位的博士学位和行为遗传学认证。培训计划的学术要求包括行为遗传学、定量和生物测定遗传学、理论和基于计算机的统计学、分子遗传学、神经科学、生物信息学和基因组学、负责任的研究行为以及行为和临床表型课程的培训。根据学位授予学术单位的不同，附加要求也有所不同。研究经验是培训不可或缺的一部分。博士后实习生还会攻读正规的课程，强调个人研究以及分子和数量行为遗传学方面的能力。为药物滥用方面的研究职业生涯做准备的其他活动包括：监督学生和/或技术人员、主办研讨会演讲者、客座演讲、每周一次的期刊俱乐部，以及在负责任地进行研究和制定个人职业计划方面的强制性培训。