Strengthening Ugandan Biomedical Engineering HIV/TB Human Resource Research Capacity

 描述（由申请人提供）：本申请的重点是加强乌干达生物医学工程艾滋病毒/结核病人力资源研究能力。撒哈拉以南非洲（SSA）用于护理或研究的大多数技术（设备）都是捐赠的，不合适且不起作用。艾滋病毒/艾滋病和相关疾病仍然是撒哈拉以南非洲地区的主要健康挑战，全球69%的艾滋病毒疾病负担都存在于撒哈拉以南非洲地区。在乌干达，估计有140万人感染艾滋病毒，根据2013年世卫组织抗逆转录病毒疗法启动指南，只有38%的人接受抗逆转录病毒疗法。结核病是一种重新出现的疾病，给撒哈拉以南非洲带来特别沉重的健康负担。在乌干达，结核病可能影响高达50%的合并感染者，是艾滋病毒血清反应阳性者死亡的主要原因，很有可能出现多药耐药（MDR）菌株。缺乏适当培训的研究人力资源，生物医学工程的研究能力，限制了技术在艾滋病毒/结核病的研究和护理在这些环境中的应用。鉴于支持艾滋病毒/结核病临床护理和研究的非技术方面的人力资源研究能力相应增长，这一点变得更加明显。需要发展能力，促进有效的生物医学工程/技术研究和利用。这项规划补助金是一项更大的努力，以促进使用适当的基本 在我们资源匮乏的环境中，科学支持艾滋病毒和结核病诊断、预防和治疗的干预措施/技术。的.这将通过与杜克大学合作开发当地生物医学工程研究生水平培训计划来实现。该团队由来自不同学科的专家/全球专家组成，不仅熟悉研究人群的当地情况，而且拥有涵盖所有技能的专业知识 从长椅到床边主要研究者运行一个经过认证的设备齐全，技术依赖的分子生物学实验室，其中包括聚合酶链反应（PCR）和DNA测序平台。该小组还将利用乌干达各种护理和研究机构/组织的机会，最大限度地提高学生在拟议的未来培训计划中的当地学习机会。目标1：通过对选定地点现有艾滋病毒研究和护理设备状况进行调查，评价乌干达利用生物医学技术进行艾滋病毒/结核病相关研究和护理的现状。目标二：将调动资源，通过与该国各利益攸关方举行一系列会议，支持研究生一级的培训和研究，以促进艾滋病毒/结核病研究和护理设备的有效利用。目标3：将与杜克大学的同事合作，准备D43培训补助金申请，以解决乌干达艾滋病毒/结核病相关研究和护理技术利用方面的差距。该项目将提供有关目前利用生物医学技术进行艾滋病毒/结核病研究的基线信息，这些信息将构成未来研究生水平生物医学工程培训计划的基础。这一方案将进一步加强人力资源，促进美国政府支持的研究能力建设努力，以实现撒哈拉以南非洲无艾滋病的一代。该项目将利用杜克大学的专业知识和马凯雷雷大学健康科学学院正在进行的其他项目，充分利用该国大量艾滋病毒/结核病阳性者提供的技术创新机会。最后，从未来的培训计划中开发的生物医学工程研究能力的人力资源将利用适当的/创新的投资安排，为全球技术产业打开撒哈拉以南非洲尚未开发的低成本、高容量技术市场。

 DESCRIPTION (provided by applicant): The focus of this application is on Strengthening Ugandan Biomedical Engineering HIV/TB Human Resource Research Capacity. Most of the technology (equipment) used for care or research in sub-Saharan Africa (SSA) is donated, inappropriate and non functional. HIV/AIDS and related illnesses remain major challenges to health in SSA, where 69% of the global HIV disease burden resides. In Uganda, 1.4 million people were estimated to be living with HIV and only 38% are receiving ART according to the 2013 WHO guidelines for ART initiation. Tuberculosis is a re-emerging disease that imposes a particularly massive health burden on sub-Saharan Africa. In Uganda TB may affect up to 50% of co-infected persons and is the leading cause of death among HIV seropositive persons with a high potential for the emergence of Multi Drug Resistant (MDR) strains. The absence of appropriately trained research human resource for research capacity in biomedical engineering limits the application of technology in HIV/TB research and care in these settings. This is becoming more marked given the corresponding growth in human resource research capacity to support non technology aspects of HIV/TB clinical care and research. There is a need to develop capacity to promote effective biomedical engineering/technology research and utilization. This planning grant is part of a larger effort to promote the use of appropriate basic science supported interventions/technologies in the diagnosis, prevention, and treatment of HIV and TB in our low resource settings. The. This will be done through the development of a local biomedical engineering graduate level training program in collaboration with Duke University. The team, composed of specialists/global experts from different disciplines, is not only familiar with the local context of the study population, but has expertise covering the full range of skills from the bench to the bedside. The principal investigator runs a certified fully equipped, technologically dependant, molecular biology laboratory that has among others Polymerase Chain Reaction (PCR) and a DNA sequencing platforms. The team will also use access to various care and research settings/organisations in Uganda to maximize the local learning opportunities of the students in the proposed future training program. This goal of the application will be achieved through the following specific aims: Aim 1: Will evaluate the current status of biomedical technology utilization for HIV/TB related research and care in Uganda through a survey on the status of existing pieces of equipment for HIV research and care at selected sites. Aim 2: Will mobilize resources to support graduate level training and research to promote effective utilization of equipment in HIV/TB research and care, through a series of meeting with various stakeholders in the country. Aim 3: will lead to the preparation the D43 training grant application to address the identified gaps in the utilization of technology for HIV/TB related research and care in Uganda, in collaboration with colleagues from Duke University. The project will provide baseline information on the current utilisation of biomedical technology for HIV/TB research in these settings that will form the basis for the future graduate level biomedical engineering training program. This program will further strengthen the human resource for research capacity building efforts and supported by the United States Government towards achieving an AIDs free generation in sub-Saharan Africa. The project will leverage the expertise from Duke University and other ongoing projects at Makerere University College of Health Sciences to fully exploit the opportunities for technological innovation offered large numbers of HIV/TB positive individuals in the country. Finally, the human resource for research capacity for biomedical engineering developed from the future training program will open up the untapped sub-Saharan African market for low cost, high volume technologies to the global technological industry using appropriate/innovative investment arrangements.